Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 2261124..2261863 Replicon chromosome
Accession NZ_AP025774
Organism Enterobacter hormaechei strain FUJ80005

Toxin (Protein)


Gene name tacT Uniprot ID A0A3S0FZ61
Locus tag NGK55_RS10870 Protein ID WP_022648141.1
Coordinates 2261124..2261609 (-) Length 162 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID A0A837FCR9
Locus tag NGK55_RS10875 Protein ID WP_003857131.1
Coordinates 2261597..2261863 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NGK55_RS10845 (FJMB80005_21190) 2257280..2258302 + 1023 WP_022648135.1 alpha/beta hydrolase -
NGK55_RS10850 (FJMB80005_21200) 2258398..2259162 + 765 WP_022648136.1 SDR family oxidoreductase -
NGK55_RS10855 (FJMB80005_21210) 2259829..2260092 + 264 WP_022648138.1 DUF4225 domain-containing protein -
NGK55_RS10860 (FJMB80005_21220) 2260067..2260396 - 330 WP_022648139.1 hypothetical protein -
NGK55_RS10865 (FJMB80005_21230) 2260529..2261098 + 570 WP_022648140.1 hypothetical protein -
NGK55_RS10870 (FJMB80005_21240) 2261124..2261609 - 486 WP_022648141.1 GNAT family N-acetyltransferase Toxin
NGK55_RS10875 (FJMB80005_21250) 2261597..2261863 - 267 WP_003857131.1 DUF1778 domain-containing protein Antitoxin
NGK55_RS10880 (FJMB80005_21260) 2261927..2262856 - 930 WP_022648142.1 LysR family transcriptional regulator -
NGK55_RS10885 (FJMB80005_21270) 2262986..2264374 + 1389 WP_022648143.1 MFS transporter -
NGK55_RS10890 (FJMB80005_21280) 2264353..2264910 - 558 WP_022648144.1 OmpH family outer membrane protein -
NGK55_RS10895 (FJMB80005_21290) 2265031..2266167 - 1137 WP_022648145.1 type 1 fimbrial protein -
NGK55_RS10900 (FJMB80005_21300) 2266191..2266769 - 579 WP_022648146.1 fimbrial protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 2238257..2264910 26653


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(58-151)

Antitoxin

Vibrio phage ICP1, Orf50

(6-82)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17558.24 Da        Isoelectric Point: 9.6275

>T40937 WP_022648141.1 NZ_AP025774:c2261609-2261124 [Enterobacter hormaechei]
VGRVTPPEPLSSVHQLAEFISGEAVLDEWLKQRGLKNQALGAARTFVVCKTGTKQVAGFYSLATGSVNHTEATGNLRRNM
PDPIPVIILARLAVDVSIRGNGLGADLLQDAVLRCYRVAENIGVRAIMVHALTEDAKAFYIHHGFKASQTQERTLFLRLP
Q

Download         Length: 486 bp

>T40937 NZ_AP025774:c2261609-2261124 [Enterobacter hormaechei]
GTGGGACGTGTAACCCCCCCAGAGCCCTTATCCAGCGTCCATCAACTGGCGGAGTTCATCAGTGGAGAGGCCGTGCTTGA
CGAATGGTTAAAACAAAGAGGTCTGAAAAACCAGGCGCTTGGCGCAGCCCGAACGTTTGTCGTTTGTAAAACGGGCACAA
AGCAGGTCGCGGGATTTTACTCTCTGGCTACCGGCAGCGTTAACCATACGGAAGCGACAGGTAATTTGCGGCGTAACATG
CCGGATCCCATTCCCGTGATTATTCTTGCCCGTCTGGCTGTCGATGTCTCAATACGCGGAAATGGGTTGGGAGCCGATTT
ACTCCAGGATGCGGTTTTACGCTGTTATCGGGTAGCAGAGAATATTGGGGTGCGGGCGATCATGGTTCATGCACTCACTG
AGGACGCCAAAGCGTTTTATATCCACCATGGTTTTAAAGCATCGCAGACTCAGGAACGGACACTGTTTCTCAGGCTTCCT
CAGTAG

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10090.50 Da        Isoelectric Point: 4.3837

>AT40937 WP_003857131.1 NZ_AP025774:c2261863-2261597 [Enterobacter hormaechei]
MKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILEMACQAAENVILDRRVFNFNDEQYAEFIDMLDAPVADDPAIEKLL
ARKPQWDV

Download         Length: 267 bp

>AT40937 NZ_AP025774:c2261863-2261597 [Enterobacter hormaechei]
ATGAAATCAGATGTTCAACTCAATCTTAGAGCCAAAGAATCCCAGCGGGCGCTTATCGATGCCGCCGCAGAGATCCTCCA
TAAATCACGTACTGACTTCATTCTGGAGATGGCCTGTCAGGCAGCCGAAAATGTGATCCTCGATCGGCGTGTATTCAATT
TTAACGATGAACAGTATGCAGAGTTCATTGATATGCTTGATGCCCCGGTCGCCGACGATCCTGCCATAGAAAAACTGCTG
GCAAGGAAACCTCAGTGGGACGTGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3S0FZ61

Antitoxin

Source ID Structure
AlphaFold DB A0A837FCR9

References