Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 1792134..1792873 Replicon chromosome
Accession NZ_AP025770
Organism Enterobacter hormaechei strain FUJ80003

Toxin (Protein)


Gene name tacT Uniprot ID A0A3S0FZ61
Locus tag NGJ61_RS08600 Protein ID WP_022648141.1
Coordinates 1792388..1792873 (+) Length 162 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID A0A837FCR9
Locus tag NGJ61_RS08595 Protein ID WP_003857131.1
Coordinates 1792134..1792400 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NGJ61_RS08570 (FJMB80003_16910) 1787228..1787806 + 579 WP_022648146.1 fimbrial protein -
NGJ61_RS08575 (FJMB80003_16920) 1787830..1788966 + 1137 WP_022648145.1 type 1 fimbrial protein -
NGJ61_RS08580 (FJMB80003_16930) 1789087..1789644 + 558 WP_022648144.1 OmpH family outer membrane protein -
NGJ61_RS08585 (FJMB80003_16940) 1789623..1791011 - 1389 WP_022648143.1 MFS transporter -
NGJ61_RS08590 (FJMB80003_16950) 1791141..1792070 + 930 WP_022648142.1 LysR family transcriptional regulator -
NGJ61_RS08595 (FJMB80003_16960) 1792134..1792400 + 267 WP_003857131.1 DUF1778 domain-containing protein Antitoxin
NGJ61_RS08600 (FJMB80003_16970) 1792388..1792873 + 486 WP_022648141.1 GNAT family N-acetyltransferase Toxin
NGJ61_RS08605 (FJMB80003_16980) 1792899..1793468 - 570 WP_022648140.1 hypothetical protein -
NGJ61_RS08610 (FJMB80003_16990) 1793601..1793930 + 330 WP_022648139.1 hypothetical protein -
NGJ61_RS08615 (FJMB80003_17000) 1793905..1794168 - 264 WP_022648138.1 DUF4225 domain-containing protein -
NGJ61_RS08620 (FJMB80003_17020) 1794835..1795599 - 765 WP_022648136.1 SDR family oxidoreductase -
NGJ61_RS08625 (FJMB80003_17030) 1795695..1796717 - 1023 WP_022648135.1 alpha/beta hydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(58-151)

Antitoxin

Vibrio phage ICP1, Orf50

(6-82)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17558.24 Da        Isoelectric Point: 9.6275

>T40906 WP_022648141.1 NZ_AP025770:1792388-1792873 [Enterobacter hormaechei]
VGRVTPPEPLSSVHQLAEFISGEAVLDEWLKQRGLKNQALGAARTFVVCKTGTKQVAGFYSLATGSVNHTEATGNLRRNM
PDPIPVIILARLAVDVSIRGNGLGADLLQDAVLRCYRVAENIGVRAIMVHALTEDAKAFYIHHGFKASQTQERTLFLRLP
Q

Download         Length: 486 bp

>T40906 NZ_AP025770:1792388-1792873 [Enterobacter hormaechei]
GTGGGACGTGTAACCCCCCCAGAGCCCTTATCCAGCGTCCATCAACTGGCGGAGTTCATCAGTGGAGAGGCCGTGCTTGA
CGAATGGTTAAAACAAAGAGGTCTGAAAAACCAGGCGCTTGGCGCAGCCCGAACGTTTGTCGTTTGTAAAACGGGCACAA
AGCAGGTCGCGGGATTTTACTCTCTGGCTACCGGCAGCGTTAACCATACGGAAGCGACAGGTAATTTGCGGCGTAACATG
CCGGATCCCATTCCCGTGATTATTCTTGCCCGTCTGGCTGTCGATGTCTCAATACGCGGAAATGGGTTGGGAGCCGATTT
ACTCCAGGATGCGGTTTTACGCTGTTATCGGGTAGCAGAGAATATTGGGGTGCGGGCGATCATGGTTCATGCACTCACTG
AGGACGCCAAAGCGTTTTATATCCACCATGGTTTTAAAGCATCGCAGACTCAGGAACGGACACTGTTTCTCAGGCTTCCT
CAGTAG

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10090.50 Da        Isoelectric Point: 4.3837

>AT40906 WP_003857131.1 NZ_AP025770:1792134-1792400 [Enterobacter hormaechei]
MKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILEMACQAAENVILDRRVFNFNDEQYAEFIDMLDAPVADDPAIEKLL
ARKPQWDV

Download         Length: 267 bp

>AT40906 NZ_AP025770:1792134-1792400 [Enterobacter hormaechei]
ATGAAATCAGATGTTCAACTCAATCTTAGAGCCAAAGAATCCCAGCGGGCGCTTATCGATGCCGCCGCAGAGATCCTCCA
TAAATCACGTACTGACTTCATTCTGGAGATGGCCTGTCAGGCAGCCGAAAATGTGATCCTCGATCGGCGTGTATTCAATT
TTAACGATGAACAGTATGCAGAGTTCATTGATATGCTTGATGCCCCGGTCGCCGACGATCCTGCCATAGAAAAACTGCTG
GCAAGGAAACCTCAGTGGGACGTGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3S0FZ61

Antitoxin

Source ID Structure
AlphaFold DB A0A837FCR9

References