Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 3746188..3746845 Replicon chromosome
Accession NZ_AP025764
Organism Enterobacter hormaechei strain FUJ80001

Toxin (Protein)


Gene name cptA Uniprot ID A0A0A6GSQ9
Locus tag NGK23_RS17860 Protein ID WP_022649305.1
Coordinates 3746188..3746598 (-) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID G8LDB7
Locus tag NGK23_RS17865 Protein ID WP_003863437.1
Coordinates 3746579..3746845 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NGK23_RS17840 (FJMB80001_34850) 3742186..3743919 - 1734 WP_022649303.1 single-stranded-DNA-specific exonuclease RecJ -
NGK23_RS17845 (FJMB80001_34860) 3743925..3744638 - 714 WP_022649304.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
NGK23_RS17850 (FJMB80001_34870) 3744667..3745563 - 897 WP_003863442.1 site-specific tyrosine recombinase XerD -
NGK23_RS17855 (FJMB80001_34880) 3745665..3746186 + 522 WP_015571793.1 flavodoxin FldB -
NGK23_RS17860 (FJMB80001_34890) 3746188..3746598 - 411 WP_022649305.1 protein YgfX Toxin
NGK23_RS17865 (FJMB80001_34900) 3746579..3746845 - 267 WP_003863437.1 FAD assembly factor SdhE Antitoxin
NGK23_RS17870 (FJMB80001_34910) 3747140..3748120 + 981 WP_022649306.1 tRNA-modifying protein YgfZ -
NGK23_RS17875 (FJMB80001_34930) 3748644..3749303 - 660 WP_022649307.1 hemolysin III family protein -
NGK23_RS17880 (FJMB80001_34940) 3749570..3750301 + 732 WP_022649308.1 MurR/RpiR family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16321.21 Da        Isoelectric Point: 11.4775

>T40884 WP_022649305.1 NZ_AP025764:c3746598-3746188 [Enterobacter hormaechei]
VVLWQSDLRVSWRSQWMSLLLHGLVAAMVLLVPWPLSYTPLWLLLLSFVVFDSVRSQRRINARQGEIKLLMDSRLRWQGK
EWEMIGTPWMLNTGMMLRLRRVEDNRRQHLWLAADSMDPAEWRDLRRLIVQQPTQE

Download         Length: 411 bp

>T40884 NZ_AP025764:c3746598-3746188 [Enterobacter hormaechei]
GTGGTCCTGTGGCAATCTGATCTTCGCGTCTCGTGGCGCTCACAGTGGATGTCCTTACTGCTCCACGGTCTGGTCGCGGC
AATGGTGTTATTGGTGCCGTGGCCGCTAAGCTATACCCCTCTGTGGCTGCTTTTGCTGTCGTTTGTAGTGTTTGACAGCG
TGCGCAGCCAGCGTCGAATTAACGCCCGTCAGGGTGAAATTAAGCTGCTGATGGATTCTCGCCTGCGCTGGCAGGGAAAA
GAGTGGGAAATGATAGGGACGCCGTGGATGCTCAACACCGGGATGATGCTACGGCTGCGTCGGGTCGAGGACAATCGTCG
CCAGCACCTGTGGCTGGCAGCAGACAGTATGGATCCTGCGGAGTGGCGAGATCTGCGCCGGTTGATCGTGCAACAGCCGA
CGCAGGAGTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10526.96 Da        Isoelectric Point: 4.8310

>AT40884 WP_003863437.1 NZ_AP025764:c3746845-3746579 [Enterobacter hormaechei]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDSLSDDDKRLFVRLLESDDPDLFNWLMNHGKPADTELQRMVQLIQTRN
QERGPVAI

Download         Length: 267 bp

>AT40884 NZ_AP025764:c3746845-3746579 [Enterobacter hormaechei]
ATGGATATTAACAACAAGGCCCGTATTCACTGGGCGTGCCGTCGCGGCATGCGTGAACTTGATATCTCCATCATGCCTTT
CTTCGAGTATGAGTACGACAGCTTAAGCGATGACGATAAGCGCCTGTTTGTCCGTCTGCTTGAGTCCGACGATCCGGATT
TATTCAACTGGCTGATGAATCACGGCAAGCCCGCCGACACCGAGTTGCAACGGATGGTGCAATTAATTCAAACACGGAAT
CAGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0A6GSQ9

Antitoxin

Source ID Structure
AlphaFold DB A0A837F8P5

References