Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 2260327..2261066 Replicon chromosome
Accession NZ_AP025764
Organism Enterobacter hormaechei strain FUJ80001

Toxin (Protein)


Gene name tacT Uniprot ID A0A3S0FZ61
Locus tag NGK23_RS10860 Protein ID WP_022648141.1
Coordinates 2260327..2260812 (-) Length 162 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID A0A837FCR9
Locus tag NGK23_RS10865 Protein ID WP_003857131.1
Coordinates 2260800..2261066 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NGK23_RS10835 (FJMB80001_21160) 2256483..2257505 + 1023 WP_022648135.1 alpha/beta hydrolase -
NGK23_RS10840 (FJMB80001_21170) 2257601..2258365 + 765 WP_022648136.1 SDR family oxidoreductase -
NGK23_RS10845 (FJMB80001_21190) 2259032..2259295 + 264 WP_022648138.1 DUF4225 domain-containing protein -
NGK23_RS10850 (FJMB80001_21200) 2259270..2259599 - 330 WP_022648139.1 hypothetical protein -
NGK23_RS10855 (FJMB80001_21210) 2259732..2260301 + 570 WP_022648140.1 hypothetical protein -
NGK23_RS10860 (FJMB80001_21220) 2260327..2260812 - 486 WP_022648141.1 GNAT family N-acetyltransferase Toxin
NGK23_RS10865 (FJMB80001_21230) 2260800..2261066 - 267 WP_003857131.1 DUF1778 domain-containing protein Antitoxin
NGK23_RS10870 (FJMB80001_21240) 2261130..2262059 - 930 WP_022648142.1 LysR family transcriptional regulator -
NGK23_RS10875 (FJMB80001_21250) 2262189..2263577 + 1389 WP_022648143.1 MFS transporter -
NGK23_RS10880 (FJMB80001_21260) 2263556..2264113 - 558 WP_022648144.1 OmpH family outer membrane protein -
NGK23_RS10885 (FJMB80001_21270) 2264234..2265370 - 1137 WP_022648145.1 type 1 fimbrial protein -
NGK23_RS10890 (FJMB80001_21280) 2265394..2265972 - 579 WP_022648146.1 fimbrial protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 2237460..2264113 26653


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(58-151)

Antitoxin

Vibrio phage ICP1, Orf50

(6-82)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17558.24 Da        Isoelectric Point: 9.6275

>T40874 WP_022648141.1 NZ_AP025764:c2260812-2260327 [Enterobacter hormaechei]
VGRVTPPEPLSSVHQLAEFISGEAVLDEWLKQRGLKNQALGAARTFVVCKTGTKQVAGFYSLATGSVNHTEATGNLRRNM
PDPIPVIILARLAVDVSIRGNGLGADLLQDAVLRCYRVAENIGVRAIMVHALTEDAKAFYIHHGFKASQTQERTLFLRLP
Q

Download         Length: 486 bp

>T40874 NZ_AP025764:c2260812-2260327 [Enterobacter hormaechei]
GTGGGACGTGTAACCCCCCCAGAGCCCTTATCCAGCGTCCATCAACTGGCGGAGTTCATCAGTGGAGAGGCCGTGCTTGA
CGAATGGTTAAAACAAAGAGGTCTGAAAAACCAGGCGCTTGGCGCAGCCCGAACGTTTGTCGTTTGTAAAACGGGCACAA
AGCAGGTCGCGGGATTTTACTCTCTGGCTACCGGCAGCGTTAACCATACGGAAGCGACAGGTAATTTGCGGCGTAACATG
CCGGATCCCATTCCCGTGATTATTCTTGCCCGTCTGGCTGTCGATGTCTCAATACGCGGAAATGGGTTGGGAGCCGATTT
ACTCCAGGATGCGGTTTTACGCTGTTATCGGGTAGCAGAGAATATTGGGGTGCGGGCGATCATGGTTCATGCACTCACTG
AGGACGCCAAAGCGTTTTATATCCACCATGGTTTTAAAGCATCGCAGACTCAGGAACGGACACTGTTTCTCAGGCTTCCT
CAGTAG

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10090.50 Da        Isoelectric Point: 4.3837

>AT40874 WP_003857131.1 NZ_AP025764:c2261066-2260800 [Enterobacter hormaechei]
MKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILEMACQAAENVILDRRVFNFNDEQYAEFIDMLDAPVADDPAIEKLL
ARKPQWDV

Download         Length: 267 bp

>AT40874 NZ_AP025764:c2261066-2260800 [Enterobacter hormaechei]
ATGAAATCAGATGTTCAACTCAATCTTAGAGCCAAAGAATCCCAGCGGGCGCTTATCGATGCCGCCGCAGAGATCCTCCA
TAAATCACGTACTGACTTCATTCTGGAGATGGCCTGTCAGGCAGCCGAAAATGTGATCCTCGATCGGCGTGTATTCAATT
TTAACGATGAACAGTATGCAGAGTTCATTGATATGCTTGATGCCCCGGTCGCCGACGATCCTGCCATAGAAAAACTGCTG
GCAAGGAAACCTCAGTGGGACGTGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3S0FZ61

Antitoxin

Source ID Structure
AlphaFold DB A0A837FCR9

References