Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /Xre(antitoxin)
Location 3425844..3426964 Replicon chromosome
Accession NZ_AP025761
Organism Amphritea japonica strain JCM 14782

Toxin (Protein)


Gene name - Uniprot ID A0A7R6P581
Locus tag PT3_RS15680 Protein ID WP_019623034.1
Coordinates 3425844..3426593 (-) Length 250 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID A0A7R6P5F1
Locus tag PT3_RS15685 Protein ID WP_019623035.1
Coordinates 3426593..3426964 (-) Length 124 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PT3_RS15660 3422020..3422898 - 879 WP_019623031.1 LysR family transcriptional regulator -
PT3_RS15665 3423042..3423815 + 774 WP_019623032.1 ferredoxin--NADP reductase -
PT3_RS15675 3424547..3425767 + 1221 WP_019623033.1 GGDEF domain-containing protein -
PT3_RS15680 3425844..3426593 - 750 WP_019623034.1 RES family NAD+ phosphorylase Toxin
PT3_RS15685 3426593..3426964 - 372 WP_019623035.1 MbcA/ParS/Xre antitoxin family protein Antitoxin
PT3_RS15690 3427073..3428806 - 1734 WP_019623036.1 protein adenylyltransferase SelO family protein -
PT3_RS15695 3429087..3429635 - 549 WP_019623037.1 DoxX family protein -
PT3_RS15700 3429645..3430514 - 870 WP_019623038.1 DNA-binding domain-containing protein -
PT3_RS15705 3430514..3431443 - 930 WP_040405024.1 DUF692 domain-containing protein -
PT3_RS15710 3431433..3431780 - 348 WP_019623040.1 DUF2282 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RES domain

(61-203)

Antitoxin

Antitoxin Xre-like, helix-turn-helix domain

(8-68)


Sequences

Toxin        


Download         Length: 250 a.a.        Molecular weight: 27750.15 Da        Isoelectric Point: 4.5560

>T40871 WP_019623034.1 NZ_AP025761:c3426593-3425844 [Amphritea japonica]
MIWQACDGVEQIKPIAGTLYRLVESQEQVATTGYVDTLEEQAILEKLLEASKPDYPEEITAGLHYLLSTPFRYPPLEWGS
RFGSKYEPSLFYGGELLESTLAESAYYRFVFLLAMEGEPPGKRLNTEHTLFTVTYSTQRGILLQHSPFNTYADQLTHPQD
YASSQALGTEMRKAGVEAFQYLSARSTESGVCAALYTATAFTHNQPDTTAQWLCELTTTGVTFKAVASPRTYHYPLSQFA
VDGELPLPA

Download         Length: 750 bp

>T40871 NZ_AP025761:c3426593-3425844 [Amphritea japonica]
ATGATCTGGCAGGCCTGTGACGGTGTAGAGCAGATCAAACCCATAGCGGGTACTTTATACCGACTGGTTGAGAGTCAGGA
GCAAGTGGCGACGACAGGTTATGTTGATACACTCGAAGAACAGGCGATACTGGAAAAGTTGCTGGAAGCCTCAAAACCCG
ACTATCCGGAAGAAATTACAGCAGGGCTTCATTATCTGCTGAGCACGCCTTTTCGCTACCCGCCACTGGAATGGGGGTCG
CGCTTTGGGAGCAAATACGAGCCCAGTCTGTTCTACGGAGGGGAATTACTGGAAAGTACACTGGCAGAGTCTGCTTATTA
TCGGTTTGTCTTCTTGCTGGCAATGGAGGGTGAACCACCCGGTAAACGGCTCAACACAGAGCACACCTTGTTTACGGTTA
CCTACAGTACACAACGGGGCATACTGCTTCAGCACTCCCCATTTAATACCTATGCAGATCAGCTAACTCATCCGCAGGAT
TATGCTTCGTCACAAGCGCTTGGAACAGAAATGCGTAAAGCGGGTGTGGAAGCGTTCCAGTATCTTTCTGCCCGGTCAAC
TGAATCGGGGGTATGCGCAGCACTCTATACGGCAACCGCGTTTACACATAATCAGCCTGATACAACCGCACAGTGGCTCT
GTGAACTGACAACAACCGGAGTGACCTTCAAAGCCGTTGCTTCCCCCCGAACCTATCATTACCCGCTGTCACAATTCGCA
GTGGATGGAGAGCTGCCGCTGCCGGCCTGA

Antitoxin


Download         Length: 124 a.a.        Molecular weight: 13413.67 Da        Isoelectric Point: 11.3344

>AT40871 WP_019623035.1 NZ_AP025761:c3426964-3426593 [Amphritea japonica]
MSAQLKQRPDAAAVLCKAMFNASEQLTLNQQELGRVVGINRTGVSRLKQSGLLDPASKRGELALLLIRAARALFALSGGN
HDWIKHFMRSNNKLTGGIPAEQMQSVQGLMRVVTYLDAIRGKV

Download         Length: 372 bp

>AT40871 NZ_AP025761:c3426964-3426593 [Amphritea japonica]
ATGTCTGCACAACTGAAGCAACGACCTGATGCGGCTGCCGTGCTTTGTAAGGCGATGTTCAACGCGTCTGAGCAACTGAC
ACTGAACCAGCAAGAGCTAGGCAGAGTCGTTGGTATTAATCGCACCGGGGTATCACGTCTTAAACAGAGCGGTTTACTGG
ATCCTGCATCCAAGCGGGGTGAACTGGCATTGCTATTGATTCGCGCTGCACGGGCTCTCTTTGCATTGTCCGGTGGTAAT
CATGACTGGATCAAGCACTTTATGCGTTCAAACAATAAACTGACTGGCGGCATTCCTGCGGAACAGATGCAGAGTGTTCA
GGGTTTGATGCGTGTTGTCACTTATCTGGATGCTATCCGGGGCAAGGTGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7R6P581

Antitoxin

Source ID Structure
AlphaFold DB A0A7R6P5F1

References