Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-DnaT
Location 43155..43677 Replicon plasmid pla1
Accession NZ_AP025755
Organism Escherichia sp. KS167_9B strain KS-P079

Toxin (Protein)


Gene name relE Uniprot ID A0A2A6Q014
Locus tag QUE34_RS26825 Protein ID WP_000220564.1
Coordinates 43155..43436 (-) Length 94 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A0B0W3C1
Locus tag QUE34_RS26830 Protein ID WP_000121742.1
Coordinates 43426..43677 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QUE34_RS26800 (38757) 38757..39748 - 992 Protein_40 IS256 family transposase -
QUE34_RS26805 (39788) 39788..41359 - 1572 WP_000381395.1 IS66-like element ISCro1 family transposase -
QUE34_RS26810 (41379) 41379..41726 - 348 WP_000624622.1 IS66 family insertion sequence element accessory protein TnpB -
QUE34_RS26815 (41726) 41726..42403 - 678 WP_001339397.1 IS66-like element accessory protein TnpA -
QUE34_RS26820 (42465) 42465..42671 - 207 Protein_44 IS256 family transposase -
QUE34_RS26825 (43155) 43155..43436 - 282 WP_000220564.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
QUE34_RS26830 (43426) 43426..43677 - 252 WP_000121742.1 hypothetical protein Antitoxin
QUE34_RS26835 (43953) 43953..44972 - 1020 WP_024262278.1 IS110 family transposase -
QUE34_RS26840 (46349) 46349..46350 - 2 WP_097638450.1 IS3 family transposase -
QUE34_RS26845 (46682) 46682..47485 - 804 Protein_49 IS256-like element IS1414 family transposase -
QUE34_RS26850 (47657) 47657..48277 - 621 WP_000269722.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid - hlyD / hlyD / hlyD / hlyB / hlyB / hlyA / hlyC / estIa / faeJ / faeI / faeH / faeF / faeE / faeD / faeC / espP 1..215429 215429
- inside IScluster/Tn - - 33164..69049 35885


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-86)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 11009.78 Da        Isoelectric Point: 10.5938

>T40857 WP_000220564.1 NZ_AP025755:c43436-43155 [Escherichia sp. KS167_9B]
MTYELAFDRRALKEWQKLGHTIREQFKKKLSERLENPRAPAARLHGHADRYKIKLRSSGYRLVYQVIDEKVVLLVIAVGR
RESSEVYQIADLR

Download         Length: 282 bp

>T40857 NZ_AP025755:c43436-43155 [Escherichia sp. KS167_9B]
ATGACCTATGAACTGGCTTTTGACCGCAGAGCACTGAAGGAATGGCAGAAACTCGGCCACACCATCCGTGAACAATTCAA
AAAGAAACTGTCAGAACGGCTGGAAAATCCACGCGCACCTGCAGCCCGATTACATGGTCATGCTGATCGTTATAAAATCA
AACTTCGTTCATCTGGCTACAGACTTGTATATCAAGTCATTGATGAGAAAGTCGTTTTACTCGTTATTGCCGTTGGAAGA
AGAGAAAGCAGCGAAGTCTATCAGATCGCAGATTTGCGCTAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9181.47 Da        Isoelectric Point: 4.2958

>AT40857 WP_000121742.1 NZ_AP025755:c43677-43426 [Escherichia sp. KS167_9B]
MSYQILTTTAASITDLKKNPMGTVAEGEGDAVAILNRNEPAFYCVPPKLYAYYRELAEDAELNAVADERMKKPEIVKVSL
DDL

Download         Length: 252 bp

>AT40857 NZ_AP025755:c43677-43426 [Escherichia sp. KS167_9B]
ATGAGTTATCAAATCCTGACAACCACAGCGGCCAGTATTACTGACCTAAAAAAAAATCCTATGGGAACCGTAGCTGAAGG
TGAAGGGGACGCTGTTGCAATCCTGAACCGAAACGAACCGGCGTTCTATTGCGTTCCACCAAAACTTTACGCCTACTATC
GGGAACTCGCTGAAGATGCTGAGTTAAACGCTGTTGCTGATGAGCGCATGAAAAAACCGGAAATTGTGAAGGTTAGCCTG
GATGACCTATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2A6Q014

Antitoxin

Source ID Structure
AlphaFold DB A0A0B0W3C1

References