Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 3566070..3566724 Replicon chromosome
Accession NZ_AP025754
Organism Escherichia sp. KS167_9B strain KS-P079

Toxin (Protein)


Gene name cptA Uniprot ID F0JPE9
Locus tag QUE34_RS17920 Protein ID WP_000244774.1
Coordinates 3566070..3566477 (-) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S1PPB1
Locus tag QUE34_RS17925 Protein ID WP_000354046.1
Coordinates 3566458..3566724 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QUE34_RS17900 (3562027) 3562027..3563760 - 1734 WP_103253719.1 single-stranded-DNA-specific exonuclease RecJ -
QUE34_RS17905 (3563766) 3563766..3564476 - 711 WP_000715223.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
QUE34_RS17910 (3564501) 3564501..3565397 - 897 WP_000806638.1 site-specific tyrosine recombinase XerD -
QUE34_RS17915 (3565509) 3565509..3566030 + 522 WP_001055874.1 flavodoxin FldB -
QUE34_RS17920 (3566070) 3566070..3566477 - 408 WP_000244774.1 protein YgfX Toxin
QUE34_RS17925 (3566458) 3566458..3566724 - 267 WP_000354046.1 FAD assembly factor SdhE Antitoxin
QUE34_RS17930 (3566976) 3566976..3567956 + 981 WP_103253718.1 tRNA-modifying protein YgfZ -
QUE34_RS17935 (3568033) 3568033..3568692 - 660 WP_000250274.1 hemolysin III family protein -
QUE34_RS17940 (3568856) 3568856..3569167 - 312 WP_039020582.1 N(4)-acetylcytidine aminohydrolase -
QUE34_RS17945 (3569212) 3569212..3570645 + 1434 WP_141218821.1 6-phospho-beta-glucosidase BglA -
QUE34_RS17950 (3570707) 3570707..3571450 - 744 WP_000150658.1 SDR family oxidoreductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 16078.05 Da        Isoelectric Point: 11.2511

>T40851 WP_000244774.1 NZ_AP025754:c3566477-3566070 [Escherichia sp. KS167_9B]
VVLWQSDLRVSWRAQWLSLLIHGLVAAVILLMPWPLSYTPLWMVLLSLVVFDCVRSQRRINARQGEIRLLMDGRLRWQGQ
EWCIVKAPWMIKSGMMLRLRSDSGKRQHLWLAADSMDEAEWRDLRRILLQQETQR

Download         Length: 408 bp

>T40851 NZ_AP025754:c3566477-3566070 [Escherichia sp. KS167_9B]
GTGGTCCTGTGGCAATCTGATTTACGCGTCTCCTGGCGCGCGCAGTGGCTTTCCTTGCTGATTCATGGGCTGGTTGCCGC
TGTTATTTTACTCATGCCCTGGCCGTTAAGTTACACCCCGTTATGGATGGTGTTACTTTCGCTGGTGGTGTTTGATTGCG
TTCGCAGCCAGCGACGCATTAATGCTCGCCAGGGGGAAATTCGCCTGTTGATGGACGGGCGTTTGCGTTGGCAAGGGCAG
GAGTGGTGCATCGTCAAAGCGCCGTGGATGATTAAAAGCGGCATGATGTTGCGTTTACGTTCTGATAGCGGTAAACGTCA
GCACTTGTGGCTGGCAGCCGACAGCATGGACGAAGCCGAATGGCGGGATTTACGGCGGATTTTGTTGCAACAAGAGACGC
AAAGATAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10547.12 Da        Isoelectric Point: 5.1599

>AT40851 WP_000354046.1 NZ_AP025754:c3566724-3566458 [Escherichia sp. KS167_9B]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRIFIRLLECDDPDLFNWLMNHGKPADAELEMMVRLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT40851 NZ_AP025754:c3566724-3566458 [Escherichia sp. KS167_9B]
ATGGACATTAATAACAAAGCCCGCATTCACTGGGCATGCCGCCGTGGTATGCGCGAACTCGATATTTCAATCATGCCGTT
TTTCGAACATGAGTACGACAGCTTAAGTGATGACGAAAAACGCATCTTTATTCGTCTGCTGGAATGTGACGATCCCGATC
TGTTCAACTGGCTGATGAATCACGGTAAACCGGCCGATGCAGAACTGGAAATGATGGTCCGACTCATCCAGACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0L6ZX35

Antitoxin

Source ID Structure
PDB 6B58
PDB 1X6I
PDB 1X6J
PDB 6C12
AlphaFold DB A0A7U9QD57

References