Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | paaR-paaA-parE/- |
| Location | 1585300..1585781 | Replicon | chromosome |
| Accession | NZ_AP025754 | ||
| Organism | Escherichia sp. KS167_9B strain KS-P079 | ||
Toxin (Protein)
| Gene name | parE_1 | Uniprot ID | A0A0B1KMH3 |
| Locus tag | QUE34_RS07885 | Protein ID | WP_042966241.1 |
| Coordinates | 1585300..1585590 (-) | Length | 97 a.a. |
Antitoxin (Protein)
| Gene name | paaA | Uniprot ID | A0A0B1KNA0 |
| Locus tag | QUE34_RS07890 | Protein ID | WP_042966240.1 |
| Coordinates | 1585590..1585781 (-) | Length | 64 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| QUE34_RS07850 (1580428) | 1580428..1582899 | - | 2472 | WP_042970837.1 | exonuclease | - |
| QUE34_RS07855 (1582980) | 1582980..1583183 | - | 204 | WP_001098749.1 | DUF1482 family protein | - |
| QUE34_RS07860 (1583186) | 1583186..1583368 | - | 183 | WP_000449182.1 | cell division inhibition protein DicB | - |
| QUE34_RS07865 (1583914) | 1583914..1584426 | + | 513 | WP_042970839.1 | hypothetical protein | - |
| QUE34_RS07870 (1584553) | 1584553..1584726 | + | 174 | WP_157839757.1 | hypothetical protein | - |
| QUE34_RS07875 (1584711) | 1584711..1584869 | - | 159 | WP_021562152.1 | hypothetical protein | - |
| QUE34_RS07880 (1584881) | 1584881..1585033 | - | 153 | WP_042970855.1 | DUF1391 family protein | - |
| QUE34_RS07885 (1585300) | 1585300..1585590 | - | 291 | WP_042966241.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| QUE34_RS07890 (1585590) | 1585590..1585781 | - | 192 | WP_042966240.1 | hypothetical protein | Antitoxin |
| QUE34_RS07895 (1585799) | 1585799..1586299 | - | 501 | WP_033812093.1 | helix-turn-helix transcriptional regulator | - |
| QUE34_RS07900 (1586407) | 1586407..1586682 | + | 276 | WP_042966239.1 | helix-turn-helix transcriptional regulator | - |
| QUE34_RS07905 (1586666) | 1586666..1587091 | + | 426 | WP_042970841.1 | toxin YdaT family protein | - |
| QUE34_RS07910 (1587116) | 1587116..1588063 | + | 948 | WP_064753740.1 | helix-turn-helix domain-containing protein | - |
| QUE34_RS07915 (1588106) | 1588106..1588507 | + | 402 | WP_042970844.1 | DUF977 family protein | - |
| QUE34_RS07920 (1588504) | 1588504..1588809 | + | 306 | WP_042970846.1 | DUF4406 domain-containing protein | - |
| QUE34_RS07925 (1588796) | 1588796..1589359 | + | 564 | WP_042970847.1 | ead/Ea22-like family protein | - |
| QUE34_RS07930 (1589356) | 1589356..1589613 | + | 258 | WP_286338947.1 | hypothetical protein | - |
| QUE34_RS07935 (1589735) | 1589735..1590046 | + | 312 | WP_042970849.1 | hypothetical protein | - |
| QUE34_RS07940 (1590175) | 1590175..1590393 | + | 219 | WP_042970850.1 | DUF4014 family protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | - | 1574872..1625706 | 50834 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 97 a.a. Molecular weight: 11206.07 Da Isoelectric Point: 9.9854
>T40835 WP_042966241.1 NZ_AP025754:c1585590-1585300 [Escherichia sp. KS167_9B]
MLPILWLPSAREDLRQIVAYIAKENPPAARRLKIRIETSVLSLTEHPYLYPPSERVPSLREIVTHPNYIILYRVTTSNIE
IVNVVHSRRQYPNKSC
MLPILWLPSAREDLRQIVAYIAKENPPAARRLKIRIETSVLSLTEHPYLYPPSERVPSLREIVTHPNYIILYRVTTSNIE
IVNVVHSRRQYPNKSC
Download Length: 291 bp
>T40835 NZ_AP025754:c1585590-1585300 [Escherichia sp. KS167_9B]
ATGCTGCCCATTTTATGGCTACCTTCTGCACGTGAGGATTTACGTCAGATAGTAGCCTATATTGCTAAAGAAAACCCTCC
CGCTGCACGTAGACTAAAAATACGCATTGAAACATCAGTTTTGTCACTTACTGAACACCCTTATCTGTACCCACCGAGCG
AAAGAGTTCCAAGTCTTCGAGAAATAGTGACTCATCCTAACTACATAATACTTTACCGAGTAACAACATCTAACATCGAG
ATCGTAAATGTAGTTCACTCACGAAGGCAGTATCCAAACAAAAGCTGTTAA
ATGCTGCCCATTTTATGGCTACCTTCTGCACGTGAGGATTTACGTCAGATAGTAGCCTATATTGCTAAAGAAAACCCTCC
CGCTGCACGTAGACTAAAAATACGCATTGAAACATCAGTTTTGTCACTTACTGAACACCCTTATCTGTACCCACCGAGCG
AAAGAGTTCCAAGTCTTCGAGAAATAGTGACTCATCCTAACTACATAATACTTTACCGAGTAACAACATCTAACATCGAG
ATCGTAAATGTAGTTCACTCACGAAGGCAGTATCCAAACAAAAGCTGTTAA
Antitoxin
Download Length: 64 a.a. Molecular weight: 6987.80 Da Isoelectric Point: 4.0270
>AT40835 WP_042966240.1 NZ_AP025754:c1585781-1585590 [Escherichia sp. KS167_9B]
MSTALSPIISEFETVEQENSYNEWLRAKVAASLADPRPAIPHDEVMAEMENLIAQLAATNRSE
MSTALSPIISEFETVEQENSYNEWLRAKVAASLADPRPAIPHDEVMAEMENLIAQLAATNRSE
Download Length: 192 bp
>AT40835 NZ_AP025754:c1585781-1585590 [Escherichia sp. KS167_9B]
ATGAGTACAGCCCTTTCCCCGATAATTTCTGAATTTGAAACGGTCGAACAAGAAAACAGCTATAACGAATGGTTGCGAGC
CAAAGTGGCAGCAAGCCTCGCAGATCCCCGTCCTGCAATTCCGCATGATGAAGTAATGGCTGAAATGGAAAACCTTATTG
CTCAATTAGCTGCAACGAACAGGAGTGAGTAA
ATGAGTACAGCCCTTTCCCCGATAATTTCTGAATTTGAAACGGTCGAACAAGAAAACAGCTATAACGAATGGTTGCGAGC
CAAAGTGGCAGCAAGCCTCGCAGATCCCCGTCCTGCAATTCCGCATGATGAAGTAATGGCTGAAATGGAAAACCTTATTG
CTCAATTAGCTGCAACGAACAGGAGTGAGTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A0B1KMH3 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A0B1KNA0 |