Detailed information of TA system
Overview
TA module
| Type | IV | Classification (family/domain) | yeeUV (cbtA-cbeA)/CbtA-CbeA |
| Location | 1366377..1367172 | Replicon | chromosome |
| Accession | NZ_AP025754 | ||
| Organism | Escherichia sp. KS167_9B strain KS-P079 | ||
Toxin (Protein)
| Gene name | yeeV | Uniprot ID | B7UP43 |
| Locus tag | QUE34_RS06765 | Protein ID | WP_000854914.1 |
| Coordinates | 1366798..1367172 (+) | Length | 125 a.a. |
Antitoxin (Protein)
| Gene name | yeeU | Uniprot ID | A0A0B0VS41 |
| Locus tag | QUE34_RS06760 | Protein ID | WP_001280954.1 |
| Coordinates | 1366377..1366751 (+) | Length | 125 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| QUE34_RS06730 (1361923) | 1361923..1362993 | + | 1071 | WP_000102669.1 | patatin-like phospholipase family protein | - |
| QUE34_RS06735 (1363440) | 1363440..1363898 | + | 459 | WP_000502112.1 | IS200/IS605 family transposase | - |
| QUE34_RS06740 (1364044) | 1364044..1364862 | + | 819 | WP_001234682.1 | DUF932 domain-containing protein | - |
| QUE34_RS06745 (1364953) | 1364953..1365438 | + | 486 | WP_000214398.1 | antirestriction protein | - |
| QUE34_RS06750 (1365454) | 1365454..1365930 | + | 477 | WP_001186738.1 | RadC family protein | - |
| QUE34_RS06755 (1365993) | 1365993..1366214 | + | 222 | WP_001220314.1 | DUF987 domain-containing protein | - |
| QUE34_RS06760 (1366377) | 1366377..1366751 | + | 375 | WP_001280954.1 | type IV toxin-antitoxin system YeeU family antitoxin | Antitoxin |
| QUE34_RS06765 (1366798) | 1366798..1367172 | + | 375 | WP_000854914.1 | TA system toxin CbtA family protein | Toxin |
| QUE34_RS06770 (1367169) | 1367169..1367660 | + | 492 | WP_000976857.1 | DUF5983 family protein | - |
| QUE34_RS06775 (1367672) | 1367672..1367869 | + | 198 | WP_000839282.1 | DUF957 domain-containing protein | - |
| QUE34_RS06780 (1367954) | 1367954..1368796 | + | 843 | WP_001280481.1 | DUF4942 domain-containing protein | - |
| QUE34_RS06790 (1369267) | 1369267..1370205 | + | 939 | WP_032302840.1 | glyoxylate/hydroxypyruvate reductase GhrA | - |
| QUE34_RS06795 (1370260) | 1370260..1370997 | + | 738 | WP_000283664.1 | zinc-binding phosphatase | - |
| QUE34_RS06800 (1371021) | 1371021..1371575 | + | 555 | WP_001001909.1 | molecular chaperone YcdY | - |
| QUE34_RS06805 (1371677) | 1371677..1372168 | + | 492 | WP_032144287.1 | DUF1097 domain-containing protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Genomic island | - | iroB / csgG / csgF / csgE / csgD / csgB / csgA / csgC | 1334166..1377106 | 42940 | |
| - | flank | IS/Tn | - | - | 1363440..1363898 | 458 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 125 a.a. Molecular weight: 14117.17 Da Isoelectric Point: 7.7761
>T40828 WP_000854914.1 NZ_AP025754:1366798-1367172 [Escherichia sp. KS167_9B]
MKTLSDTHVREVSRCPSPVTIWQTLLIRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
STCPRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKYPEAK
MKTLSDTHVREVSRCPSPVTIWQTLLIRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
STCPRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKYPEAK
Download Length: 375 bp
>T40828 NZ_AP025754:1366798-1367172 [Escherichia sp. KS167_9B]
ATGAAAACATTATCCGACACACATGTACGGGAGGTATCTCGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAT
CCGACTGCTGGACCAGCATTATGGCCTCACACTGAATGACACACCGTTTGCCGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGATGCAGTTAATTTTCTCGTGGAAAAATACGCGCTGGTGCGTACCGACCAGCCGGGATTC
AGCACCTGTCCCCGCTCTCAGTTAATAAACAGTATTGATATCCTCCGGGCTCGCCGGGCGACCGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGTAAGTATCCGGAGGCGAAATGA
ATGAAAACATTATCCGACACACATGTACGGGAGGTATCTCGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAT
CCGACTGCTGGACCAGCATTATGGCCTCACACTGAATGACACACCGTTTGCCGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGATGCAGTTAATTTTCTCGTGGAAAAATACGCGCTGGTGCGTACCGACCAGCCGGGATTC
AGCACCTGTCCCCGCTCTCAGTTAATAAACAGTATTGATATCCTCCGGGCTCGCCGGGCGACCGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGTAAGTATCCGGAGGCGAAATGA
Antitoxin
Download Length: 125 a.a. Molecular weight: 13718.51 Da Isoelectric Point: 6.6249
>AT40828 WP_001280954.1 NZ_AP025754:1366377-1366751 [Escherichia sp. KS167_9B]
VSDKLSGITHPDDNHDRPWWGLPCTVRPCFGARLVQEGNRLHYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRYQHTVTLNAKGLTCEADTLGSCGYVYLAVYPTPAPATTS
VSDKLSGITHPDDNHDRPWWGLPCTVRPCFGARLVQEGNRLHYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRYQHTVTLNAKGLTCEADTLGSCGYVYLAVYPTPAPATTS
Download Length: 375 bp
>AT40828 NZ_AP025754:1366377-1366751 [Escherichia sp. KS167_9B]
GTGTCAGACAAACTCTCCGGGATAACTCATCCCGATGACAATCACGACCGCCCCTGGTGGGGGCTTCCCTGCACAGTGAG
GCCCTGTTTTGGCGCTCGTCTGGTGCAAGAGGGTAACCGCCTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGCCGCT
TCAGCGACGCAGATGCATACCATCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGATATCAGCATACCGTCACGCTGAATGCAAAAGGGCTGACCTGCGAAGCCGACACCCTCGGCTCCTG
TGGTTACGTTTATCTGGCTGTTTATCCGACACCAGCACCCGCAACCACCTCATAA
GTGTCAGACAAACTCTCCGGGATAACTCATCCCGATGACAATCACGACCGCCCCTGGTGGGGGCTTCCCTGCACAGTGAG
GCCCTGTTTTGGCGCTCGTCTGGTGCAAGAGGGTAACCGCCTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGCCGCT
TCAGCGACGCAGATGCATACCATCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGATATCAGCATACCGTCACGCTGAATGCAAAAGGGCTGACCTGCGAAGCCGACACCCTCGGCTCCTG
TGGTTACGTTTATCTGGCTGTTTATCCGACACCAGCACCCGCAACCACCTCATAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A7U9LXR5 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A0B0VS41 |