Detailed information of TA system TA040765

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 4383680..4384292
• Replicon: chromosome
• Accession: NZ_AP025747
• Organism: Escherichia sp. HH091_1A strain HH-P024

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: -
• Locus tag: QUF14_RS21955
• Protein ID: WP_000833469.1
• Coordinates: 4384107..4384292 (-)
• Length: 62 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: -
• Locus tag: QUF14_RS21950
• Protein ID: WP_100734040.1
• Coordinates: 4383680..4384090 (-)
• Length: 137 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
QUF14_RS21935 (4379192)	4379192..4380007	-	816	WP_000891823.1	AraC family transcriptional regulator	-
QUF14_RS21940 (4380233)	4380233..4381633	+	1401	WP_286333082.1	MFS transporter	-
QUF14_RS21945 (4381644)	4381644..4383608	+	1965	WP_100734041.1	glycoside hydrolase family 127 protein	-
QUF14_RS21950 (4383680)	4383680..4384090	-	411	WP_100734040.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
QUF14_RS21955 (4384107)	4384107..4384292	-	186	WP_000833469.1	type II toxin-antitoxin system HicA family toxin	Toxin
QUF14_RS21960 (4384767)	4384767..4385846	+	1080	WP_000061478.1	type I restriction enzyme HsdR N-terminal domain-containing protein	-
QUF14_RS21965 (4385887)	4385887..4387425	-	1539	WP_000183976.1	aldehyde dehydrogenase AldB	-
QUF14_RS21970 (4387626)	4387626..4388785	-	1160	Protein_4296	L-threonine dehydrogenase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (4-59)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (3-129)

Sequences

Toxin

Protein

• Length: 62 a.a.
• Molecular weight: 6814.92 Da
• Isoelectric Point: 11.7053

>T40765 WP_000833469.1 NZ_AP025747:c4384292-4384107 [Escherichia sp. HH091_1A]
VKSADLIAILKQHGWEHIRTRGSHHQFRHPVHPGLVTVPHPKKDIKPGTLAQIGRQAGLTF

Nucleotide

• Length: 186 bp

>T40765 NZ_AP025747:c4384292-4384107 [Escherichia sp. HH091_1A]
GTGAAAAGTGCAGACCTGATCGCTATCCTGAAGCAGCATGGCTGGGAACATATTCGAACCCGTGGCAGTCATCATCAGTT
CCGCCACCCTGTTCATCCGGGTCTGGTGACGGTTCCGCACCCTAAAAAAGATATTAAGCCCGGTACGCTGGCGCAAATTG
GGCGTCAGGCTGGTTTAACATTTTAA

Antitoxin

Protein

• Length: 137 a.a.
• Molecular weight: 15225.11 Da
• Isoelectric Point: 4.5486

>AT40765 WP_100734040.1 NZ_AP025747:c4384090-4383680 [Escherichia sp. HH091_1A]
MFYPAYIHSDPDGSASGFFPDVPGCYFAGDTLDNAFQDARSALVAHFETLCEMNEELPLPGSVETHPVQRAQDFIGGQWL
LVDINMNQFEGRAERINITMPKRLLNKIDTYVRNNPDYANRSAFLAEAARRVLPGV

Nucleotide

• Length: 411 bp

>AT40765 NZ_AP025747:c4384090-4383680 [Escherichia sp. HH091_1A]
ATGTTTTATCCCGCCTATATCCACAGTGATCCTGACGGCAGCGCCAGCGGTTTTTTCCCTGATGTTCCAGGCTGTTATTT
TGCTGGTGATACGCTGGACAACGCTTTCCAGGATGCGCGAAGTGCACTGGTCGCGCACTTCGAAACCTTATGCGAGATGA
ATGAAGAGTTGCCGCTTCCAGGCTCTGTGGAAACACATCCGGTCCAGCGTGCGCAGGACTTTATTGGCGGGCAATGGTTG
CTGGTGGATATCAATATGAATCAGTTCGAAGGTCGGGCTGAACGTATCAATATTACGATGCCAAAAAGATTACTGAACAA
GATTGATACCTACGTGCGCAATAACCCAGACTATGCCAACAGAAGTGCGTTTCTGGCGGAAGCTGCCCGGCGTGTATTGC
CGGGCGTTTAA