40738

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-YafN
Location 1822..2357 Replicon plasmid pla2
Accession NZ_AP025743
Organism Escherichia sp. 10290

Toxin (Protein)


Gene name relE Uniprot ID T2HS21
Locus tag QUE74_RS28630 Protein ID WP_000222775.1
Coordinates 2070..2357 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID T2HSA2
Locus tag QUE74_RS28625 Protein ID WP_001139207.1
Coordinates 1822..2073 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QUE74_RS28615 (EsCdI10290_05672) 1..873 + 873 WP_000729440.1 incFII family plasmid replication initiator RepA -
QUE74_RS28620 (EsCdI10290_05673) 1568..1735 + 168 WP_000841010.1 hypothetical protein -
QUE74_RS28625 (EsCdI10290_05674) 1822..2073 + 252 WP_001139207.1 plasmid stabilization protein Antitoxin
QUE74_RS28630 (EsCdI10290_05675) 2070..2357 + 288 WP_000222775.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
QUE74_RS28635 (EsCdI10290_05676) 2367..2912 + 546 WP_000926984.1 hypothetical protein -
QUE74_RS28640 (EsCdI10290_05677) 3564..4166 - 603 WP_000517694.1 ProQ/FINO family protein -
QUE74_RS28645 (EsCdI10290_05678) 4520..4759 + 240 Protein_6 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid blaTEM-1B / sul2 / aph(3'')-Ib / aph(6)-Id / aph(3')-Ia / tet(A) - 1..123362 123362


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-86)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11142.17 Da        Isoelectric Point: 10.6261

>T40738 WP_000222775.1 NZ_AP025743:2070-2357 [Escherichia sp. 10290]
MTYTVKFRDDALREWLKLDKSVQQQFAKKLKKCSENPHIPSAKLRGLKDCYKIKLRASGFRLVYQVIDDMLIIAVVAVGK
RERSHVYNLASERMR

Download         Length: 288 bp

>T40738 NZ_AP025743:2070-2357 [Escherichia sp. 10290]
ATGACTTATACGGTTAAATTCAGGGATGATGCCCTCAGGGAATGGCTGAAACTGGATAAATCCGTTCAACAACAGTTCGC
AAAAAAACTAAAAAAATGCAGCGAAAATCCTCATATACCTTCAGCAAAACTACGAGGATTAAAAGATTGCTACAAAATAA
AACTTCGCGCATCAGGTTTTCGTCTGGTCTATCAGGTGATTGATGACATGTTAATTATTGCGGTTGTCGCAGTAGGTAAA
CGTGAACGTAGTCATGTTTACAATCTCGCCAGCGAGAGAATGAGATAG

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9216.45 Da        Isoelectric Point: 4.0927

>AT40738 WP_001139207.1 NZ_AP025743:1822-2073 [Escherichia sp. 10290]
MPSIILSDTSASVSELKKNPMATVSAGEGYPVAILNRNQPAFYCVPAELYERMLDAMDDQELVKLVTERSNQPLHDVDLD
SYL

Download         Length: 252 bp

>AT40738 NZ_AP025743:1822-2073 [Escherichia sp. 10290]
ATGCCCAGTATCATTTTGTCTGACACCAGTGCAAGTGTCAGTGAACTGAAAAAAAATCCAATGGCGACAGTCAGTGCCGG
AGAGGGGTATCCTGTTGCCATTCTTAACCGGAATCAGCCTGCATTCTACTGTGTTCCTGCTGAATTGTATGAAAGGATGC
TTGATGCTATGGATGACCAGGAGCTGGTGAAACTGGTTACTGAACGCAGCAATCAGCCACTACATGATGTGGACCTGGAT
AGTTATTTATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB T2HS21

Antitoxin

Source ID Structure
AlphaFold DB A0A754EQ65

References