Detailed information of TA system TA040724

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 4462627..4463239
• Replicon: chromosome
• Accession: NZ_AP025741
• Organism: Escherichia sp. 10290

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: U9YXE2
• Locus tag: QUE74_RS22505
• Protein ID: WP_000833473.1
• Coordinates: 4463054..4463239 (-)
• Length: 62 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: L4IWR9
• Locus tag: QUE74_RS22500
• Protein ID: WP_000499744.1
• Coordinates: 4462627..4463037 (-)
• Length: 137 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
QUE74_RS22475 (4458833)	4458833..4459573	-	741	WP_000906829.1	MipA/OmpV family protein	-
QUE74_RS22480 (4459697)	4459697..4460671	+	975	WP_000164020.1	LysR family transcriptional regulator	-
QUE74_RS22485 (4460668)	4460668..4461804	-	1137	WP_000364886.1	HlyD family secretion protein	-
QUE74_RS22490 (4461810)	4461810..4462133	-	324	WP_000478187.1	DUF3302 domain-containing protein	-
QUE74_RS22495 (4462316)	4462316..4462630	+	315	WP_001064341.1	hypothetical protein	-
QUE74_RS22500 (4462627)	4462627..4463037	-	411	WP_000499744.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
QUE74_RS22505 (4463054)	4463054..4463239	-	186	WP_000833473.1	type II toxin-antitoxin system HicA family toxin	Toxin
QUE74_RS22510 (4463517)	4463517..4465055	-	1539	WP_000183976.1	aldehyde dehydrogenase AldB	-
QUE74_RS22515 (4465256)	4465256..4466407	-	1152	WP_000741501.1	L-threonine dehydrogenase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (4-59)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (3-129)

Sequences

Toxin

Protein

• Length: 62 a.a.
• Molecular weight: 6800.89 Da
• Isoelectric Point: 11.7053

>T40724 WP_000833473.1 NZ_AP025741:c4463239-4463054 [Escherichia sp. 10290]
VKSADVIAILKQHGWEHIRTRGSHHQFRHPVHPGLVTVPHPKKDIKPGTLAQIGRQAGLTF

Nucleotide

• Length: 186 bp

>T40724 NZ_AP025741:c4463239-4463054 [Escherichia sp. 10290]
GTGAAAAGTGCAGACGTGATCGCCATCCTGAAGCAGCATGGCTGGGAACATATTCGAACCCGTGGTAGTCATCATCAGTT
CCGCCACCCTGTCCATCCGGGTCTGGTGACGGTTCCGCACCCTAAAAAAGATATTAAGCCCGGTACGCTGGCGCAAATTG
GGCGTCAGGCTGGTTTAACATTTTAA

Antitoxin

Protein

• Length: 137 a.a.
• Molecular weight: 15241.15 Da
• Isoelectric Point: 4.5486

>AT40724 WP_000499744.1 NZ_AP025741:c4463037-4462627 [Escherichia sp. 10290]
MFYPAYIHSDPDGSASGFFPDVPGCYFAGDTLDNAFQDARSALVAHFETLCEMNEELPLPGSVETHLVQRAQDFIGGQWL
LVDINMNQFEGRAERINITMPKRLLNKIDTYVRNNPDYANRSAFLAEAARRVLPGV

Nucleotide

• Length: 411 bp

>AT40724 NZ_AP025741:c4463037-4462627 [Escherichia sp. 10290]
ATGTTTTATCCCGCCTATATCCACAGTGATCCTGACGGCAGCGCCAGCGGTTTTTTCCCTGATGTTCCAGGCTGTTATTT
TGCTGGTGATACGCTGGACAACGCTTTCCAGGATGCGCGAAGTGCACTGGTCGCGCACTTCGAAACCTTATGCGAGATGA
ATGAAGAGTTGCCGCTTCCAGGCTCTGTGGAAACACATCTGGTCCAGCGTGCGCAGGACTTTATTGGCGGGCAATGGTTG
CTGGTGGATATCAATATGAATCAGTTCGAAGGTCGGGCTGAACGTATCAATATTACGATGCCGAAAAGATTACTGAACAA
GATTGATACCTACGTGCGCAATAACCCAGACTACGCCAACAGAAGTGCGTTTCTGGCGGAAGCTGCCCGGCGTGTATTGC
CGGGCGTTTAA

Structures

Toxin

• AlphaFold DB: U9YXE2

Antitoxin

• AlphaFold DB: L4IWR9