Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | relBE/ParE-RelB |
| Location | 2066312..2066838 | Replicon | chromosome |
| Accession | NZ_AP025741 | ||
| Organism | Escherichia sp. 10290 | ||
Toxin (Protein)
| Gene name | relE | Uniprot ID | S1EXL1 |
| Locus tag | QUE74_RS10405 | Protein ID | WP_000323025.1 |
| Coordinates | 2066312..2066599 (-) | Length | 96 a.a. |
Antitoxin (Protein)
| Gene name | relB | Uniprot ID | S1F6D3 |
| Locus tag | QUE74_RS10410 | Protein ID | WP_000534858.1 |
| Coordinates | 2066599..2066838 (-) | Length | 80 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| QUE74_RS10355 (2061336) | 2061336..2061551 | - | 216 | WP_000839590.1 | phage lysis protein EssD | - |
| QUE74_RS10360 (2061771) | 2061771..2061941 | + | 171 | WP_001405948.1 | putative zinc-binding protein YnfU | - |
| QUE74_RS10365 (2062305) | 2062305..2062520 | - | 216 | WP_000066484.1 | cold shock-like protein CspB | - |
| QUE74_RS10370 (2062821) | 2062821..2063033 | + | 213 | WP_000087756.1 | cold shock-like protein CspF | - |
| QUE74_RS10375 (2063088) | 2063088..2063177 | + | 90 | WP_120795389.1 | hypothetical protein | - |
| QUE74_RS10380 (2063455) | 2063455..2064207 | - | 753 | WP_001047135.1 | antitermination protein | - |
| QUE74_RS10385 (2064221) | 2064221..2065270 | - | 1050 | WP_061300842.1 | DUF968 domain-containing protein | - |
| QUE74_RS10390 (2065272) | 2065272..2065550 | - | 279 | WP_032140164.1 | hypothetical protein | - |
| QUE74_RS10395 (2065617) | 2065617..2065868 | - | 252 | WP_000981000.1 | protein Rem | - |
| QUE74_RS10400 (2066085) | 2066085..2066240 | - | 156 | WP_000813254.1 | type I toxin-antitoxin system toxin HokD | - |
| QUE74_RS10405 (2066312) | 2066312..2066599 | - | 288 | WP_000323025.1 | type II toxin-antitoxin system mRNA interferase RelE | Toxin |
| QUE74_RS10410 (2066599) | 2066599..2066838 | - | 240 | WP_000534858.1 | type II toxin-antitoxin system antitoxin RelB | Antitoxin |
| QUE74_RS10415 (2066863) | 2066863..2067168 | + | 306 | WP_071593935.1 | protein YdfV | - |
| QUE74_RS10420 (2067371) | 2067371..2067703 | + | 333 | WP_061300841.1 | FlxA-like family protein | - |
| QUE74_RS10425 (2068140) | 2068140..2068289 | - | 150 | WP_011443592.1 | protein YdfW | - |
| QUE74_RS10430 (2068362) | 2068362..2069459 | - | 1098 | Protein_2042 | IS1202-like element ISEsa1 family transposase | - |
| QUE74_RS10435 (2069829) | 2069829..2071316 | - | 1488 | WP_000354584.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | - | 2003839..2148985 | 145146 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 96 a.a. Molecular weight: 11225.22 Da Isoelectric Point: 10.1967
>T40711 WP_000323025.1 NZ_AP025741:c2066599-2066312 [Escherichia sp. 10290]
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL
Download Length: 288 bp
>T40711 NZ_AP025741:c2066599-2066312 [Escherichia sp. 10290]
ATGGCGTATTTTCTGGATTTTGACGAGCGGGCACTAAAGGAATGGCGAAAGCTGGGCTCGACGGTACGTGAACAGTTGAA
AAAGAAGCTGGTTGAAGTACTTGAGTCACCCCGGATTGAAGCAAACAAGCTCCGTGGTATGCCTGATTGTTACAAGATTA
AGCTCCGGTCTTCAGGCTATCGCCTTGTATACCAGGTTATAGACGAGAAAGTTGTCGTTTTCGTGATTTCTGTTGGGAAA
AGAGAACGCTCGGAAGTATATAGCGAGGCGGTCAAACGCATTCTCTGA
ATGGCGTATTTTCTGGATTTTGACGAGCGGGCACTAAAGGAATGGCGAAAGCTGGGCTCGACGGTACGTGAACAGTTGAA
AAAGAAGCTGGTTGAAGTACTTGAGTCACCCCGGATTGAAGCAAACAAGCTCCGTGGTATGCCTGATTGTTACAAGATTA
AGCTCCGGTCTTCAGGCTATCGCCTTGTATACCAGGTTATAGACGAGAAAGTTGTCGTTTTCGTGATTTCTGTTGGGAAA
AGAGAACGCTCGGAAGTATATAGCGAGGCGGTCAAACGCATTCTCTGA
Antitoxin
Download Length: 80 a.a. Molecular weight: 9071.48 Da Isoelectric Point: 4.5230
>AT40711 WP_000534858.1 NZ_AP025741:c2066838-2066599 [Escherichia sp. 10290]
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL
Download Length: 240 bp
>AT40711 NZ_AP025741:c2066838-2066599 [Escherichia sp. 10290]
ATGGGTAGCATTAACCTGCGTATTGACGATGAACTTAAAGCGCGTTCTTACGCCGCGCTTGAAAAAATGGGTGTAACTCC
TTCTGAAGCGCTTCGTCTCATGCTCGAGTATATCGCTGACAATGAACGCTTGCCGTTCAAACAGACACTCCTGAGTGATG
AAGATGCTGAACTTGTGGAGATAGTGAAAGAACGGCTTCGTAATCCTAAGCCAGTACGTGTGACGCTGGATGAACTCTGA
ATGGGTAGCATTAACCTGCGTATTGACGATGAACTTAAAGCGCGTTCTTACGCCGCGCTTGAAAAAATGGGTGTAACTCC
TTCTGAAGCGCTTCGTCTCATGCTCGAGTATATCGCTGACAATGAACGCTTGCCGTTCAAACAGACACTCCTGAGTGATG
AAGATGCTGAACTTGTGGAGATAGTGAAAGAACGGCTTCGTAATCCTAAGCCAGTACGTGTGACGCTGGATGAACTCTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|