Detailed information of TA system TA040698

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): paaR-paaA-parE/-
• Location: 1497818..1498296
• Replicon: chromosome
• Accession: NZ_AP025741
• Organism: Escherichia sp. 10290

Toxin (Protein)

• Gene name: parE_1
• Uniprot ID: A0A7D8WGY6
• Locus tag: QUE74_RS07425
• Protein ID: WP_000936798.1
• Coordinates: 1497818..1498105 (-)
• Length: 96 a.a.

Antitoxin (Protein)

• Gene name: paaA
• Uniprot ID: D8A5B4
• Locus tag: QUE74_RS07430
• Protein ID: WP_000100899.1
• Coordinates: 1498105..1498296 (-)
• Length: 64 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
QUE74_RS07395 (1493216)	1493216..1493485	-	270	WP_000003742.1	excisionase	-
QUE74_RS07400 (1493547)	1493547..1496018	-	2472	WP_286331914.1	exonuclease	-
QUE74_RS07405 (1496114)	1496114..1496302	-	189	WP_000199473.1	DUF1482 family protein	-
QUE74_RS07410 (1496299)	1496299..1496487	-	189	WP_000449175.1	cell division inhibition protein DicB	-
QUE74_RS07415 (1497007)	1497007..1497381	-	375	WP_032180882.1	hypothetical protein	-
QUE74_RS07420 (1497393)	1497393..1497545	-	153	WP_032190801.1	DUF1391 family protein	-
QUE74_RS07425 (1497818)	1497818..1498105	-	288	WP_000936798.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
QUE74_RS07430 (1498105)	1498105..1498296	-	192	WP_000100899.1	hypothetical protein	Antitoxin
QUE74_RS07435 (1498324)	1498324..1498725	-	402	WP_001329851.1	helix-turn-helix domain-containing protein	-
QUE74_RS07440 (1498835)	1498835..1499107	+	273	WP_000887447.1	YdaS family helix-turn-helix protein	-
QUE74_RS07445 (1499091)	1499091..1499516	+	426	WP_032207470.1	toxin YdaT family protein	-
QUE74_RS07450 (1499537)	1499537..1500502	+	966	WP_001422090.1	hypothetical protein	-
QUE74_RS07455 (1500509)	1500509..1501255	+	747	WP_001409081.1	ATP-binding protein	-
QUE74_RS07460 (1501277)	1501277..1502047	+	771	WP_105268832.1	DUF1627 domain-containing protein	-
QUE74_RS07465 (1502063)	1502063..1502458	+	396	WP_001118159.1	DUF977 family protein	-
QUE74_RS07470 (1502515)	1502515..1503099	+	585	WP_000627694.1	DUF551 domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	1485322..1557676	72354

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-91)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 96 a.a.
• Molecular weight: 10899.83 Da
• Isoelectric Point: 10.1360

>T40698 WP_000936798.1 NZ_AP025741:c1498105-1497818 [Escherichia sp. 10290]
MLPILWLPSARDDLRQIVAYIAKENIPAARRLKIRIETSVLALSEHPYLYPPSDRVSGLREIVVHPNYIVLYRVAASSIE
IANIVHARRQFPFPI

Nucleotide

• Length: 288 bp

>T40698 NZ_AP025741:c1498105-1497818 [Escherichia sp. 10290]
ATGTTACCCATTTTGTGGCTACCATCTGCTCGCGATGATTTGCGTCAGATCGTAGCCTATATTGCTAAGGAAAATATTCC
TGCAGCACGCAGACTAAAAATACGGATTGAAACGTCTGTTTTAGCCCTCTCTGAGCATCCATATCTATATCCGCCAAGTG
ATCGAGTATCCGGTTTGCGGGAAATTGTGGTTCACCCTAATTATATCGTTTTGTACCGAGTAGCAGCTTCAAGCATTGAA
ATTGCAAATATTGTGCATGCCCGCCGACAATTTCCCTTCCCTATCTGA

Antitoxin

Protein

• Length: 64 a.a.
• Molecular weight: 7035.80 Da
• Isoelectric Point: 4.0270

>AT40698 WP_000100899.1 NZ_AP025741:c1498296-1498105 [Escherichia sp. 10290]
MSTALSPIVSEFETTEQENSYNEWLRAKVASSLADPRPSIPHDEVMAEMENLIAQIAVTNRSE

Nucleotide

• Length: 192 bp

>AT40698 NZ_AP025741:c1498296-1498105 [Escherichia sp. 10290]
ATGAGTACAGCCCTTTCTCCGATAGTTTCAGAATTCGAAACTACCGAACAAGAAAACAGTTACAACGAATGGTTACGCGC
TAAAGTGGCGTCAAGCCTTGCTGACCCTCGTCCCTCAATTCCACATGATGAGGTAATGGCTGAAATGGAGAATCTTATTG
CTCAAATTGCTGTAACTAACAGGAGCGAGTAA

Structures

Toxin

• AlphaFold DB: A0A7D8WGY6

Antitoxin

• AlphaFold DB: A0A161RC07