Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/-
Location 454025..454678 Replicon chromosome
Accession NZ_AP025740
Organism Acinetobacter baumannii strain ATCC 19606

Toxin (Protein)


Gene name cptA Uniprot ID D0CD27
Locus tag OO714_RS02170 Protein ID WP_000607073.1
Coordinates 454289..454678 (+) Length 130 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID V5V966
Locus tag OO714_RS02165 Protein ID WP_001288210.1
Coordinates 454025..454282 (+) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OO714_RS02145 (KAMO5_04300) 449540..450547 + 1008 WP_000198631.1 DNA-directed RNA polymerase subunit alpha -
OO714_RS02150 (KAMO5_04310) 450566..450943 + 378 WP_001216380.1 50S ribosomal protein L17 -
OO714_RS02155 (KAMO5_04320) 451125..452615 + 1491 WP_000415127.1 NAD(P)/FAD-dependent oxidoreductase -
OO714_RS02160 (KAMO5_04330) 452665..453837 - 1173 WP_001190553.1 acyl-CoA dehydrogenase family protein -
OO714_RS02165 (KAMO5_04340) 454025..454282 + 258 WP_001288210.1 succinate dehydrogenase assembly factor 2 Antitoxin
OO714_RS02170 (KAMO5_04350) 454289..454678 + 390 WP_000607073.1 membrane protein Toxin
OO714_RS02175 (KAMO5_04370) 455448..456530 + 1083 WP_000049103.1 hypothetical protein -
OO714_RS02180 (KAMO5_04380) 456609..457175 + 567 WP_000651536.1 rhombosortase -
OO714_RS02185 (KAMO5_04390) 457363..459558 + 2196 WP_001158905.1 TRAP transporter large permease subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Flavinator of succinate dehydrogenase

(10-82)


Sequences

Toxin        


Download         Length: 130 a.a.        Molecular weight: 15635.91 Da        Isoelectric Point: 10.3890

>T40695 WP_000607073.1 NZ_AP025740:454289-454678 [Acinetobacter baumannii]
MINHLNFKLKYSRFSIIFQFFIGLSLAVLFYQLMPLLWWLVVISLLFISFIFFLKRPQLAQIAYLDKKLWSLAYHSQNTI
SRVKILKIIDYQIFIVIYFEGHKTLTSIIWFDQMSLAEWKKLKTLEKLY

Download         Length: 390 bp

>T40695 NZ_AP025740:454289-454678 [Acinetobacter baumannii]
TTGATCAACCATTTGAATTTTAAGCTGAAATATAGTCGTTTTTCGATTATATTTCAGTTTTTTATTGGCTTAAGCTTAGC
AGTTCTATTTTATCAATTAATGCCGTTACTATGGTGGTTAGTTGTAATCAGCTTACTATTTATCAGCTTTATTTTCTTTT
TAAAGCGTCCGCAGCTTGCACAAATTGCTTATTTAGATAAAAAACTATGGTCGCTTGCTTATCACTCACAGAACACCATT
TCTCGCGTCAAAATTTTAAAAATAATTGATTATCAGATTTTCATAGTGATCTATTTTGAAGGTCATAAAACACTAACTTC
TATCATTTGGTTTGATCAAATGTCATTAGCAGAGTGGAAAAAGCTTAAAACTTTAGAAAAACTCTATTAA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 10318.77 Da        Isoelectric Point: 4.6150

>AT40695 WP_001288210.1 NZ_AP025740:454025-454282 [Acinetobacter baumannii]
MSEEMTLEERKVIYRARRGLKEIDVYFDPYVKNYYLKADPAEKALFAELVEQEDPDLLDWFMEVSEPPRTELRDFIYKLK
HYVHG

Download         Length: 258 bp

>AT40695 NZ_AP025740:454025-454282 [Acinetobacter baumannii]
ATGTCTGAAGAAATGACCTTGGAAGAACGTAAAGTAATCTATCGCGCACGTCGTGGTTTAAAGGAAATTGATGTCTATTT
TGACCCTTATGTGAAAAATTATTATTTAAAGGCAGACCCGGCAGAAAAAGCATTGTTTGCTGAGTTGGTAGAACAGGAAG
ACCCTGATTTACTAGATTGGTTTATGGAAGTATCAGAACCACCACGTACCGAATTACGTGACTTTATCTATAAATTAAAA
CACTATGTTCATGGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB D0CD27

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4BQM7

References