Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 2748116..2748558 Replicon chromosome
Accession NZ_AP025732
Organism Nostoc cf. commune SO-36

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag ANSO36C_RS12020 Protein ID WP_251959720.1
Coordinates 2748340..2748558 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag ANSO36C_RS12015 Protein ID WP_251959719.1
Coordinates 2748116..2748343 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ANSO36C_RS11985 (ANSO36C_24100) 2744350..2744679 - 330 WP_251959715.1 STAS domain-containing protein -
ANSO36C_RS11990 (ANSO36C_24110) 2745151..2745351 + 201 WP_190938933.1 hypothetical protein -
ANSO36C_RS11995 (ANSO36C_24120) 2745522..2745938 - 417 WP_251959716.1 hypothetical protein -
ANSO36C_RS12000 (ANSO36C_24130) 2746239..2746520 + 282 WP_069070124.1 ATP-dependent Clp protease adapter ClpS -
ANSO36C_RS12005 (ANSO36C_24140) 2746587..2747411 + 825 WP_251959717.1 type II CAAX endopeptidase family protein -
ANSO36C_RS12010 (ANSO36C_24150) 2747533..2748000 + 468 WP_251959718.1 hypothetical protein -
ANSO36C_RS12015 (ANSO36C_24160) 2748116..2748343 + 228 WP_251959719.1 DUF2281 domain-containing protein Antitoxin
ANSO36C_RS12020 (ANSO36C_24170) 2748340..2748558 + 219 WP_251959720.1 PIN domain-containing protein Toxin
ANSO36C_RS12025 (ANSO36C_24180) 2748620..2749819 + 1200 WP_251960248.1 ISAzo13 family transposase -
ANSO36C_RS12030 (ANSO36C_24190) 2749803..2750039 + 237 WP_251959721.1 type II toxin-antitoxin system VapC family toxin -
ANSO36C_RS12035 (ANSO36C_24200) 2750213..2750509 - 297 WP_251959722.1 hypothetical protein -
ANSO36C_RS12040 (ANSO36C_24210) 2750671..2751309 - 639 WP_251959723.1 pentapeptide repeat-containing protein -
ANSO36C_RS12045 (ANSO36C_24220) 2751306..2752703 - 1398 WP_251959724.1 DICT sensory domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-61)

Antitoxin

Domain of unknown function DUF2281

(6-73)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8205.48 Da        Isoelectric Point: 4.9692

>T40690 WP_251959720.1 NZ_AP025732:2748340-2748558 [Nostoc cf. commune SO-36]
MNRLLLDTHAFIWFVSNDATLPVLTREKIESAEAVFFSIASLWEMAIKLNIGKLSLQGAFEEIEPKRTPQNN

Download         Length: 219 bp

>T40690 NZ_AP025732:2748340-2748558 [Nostoc cf. commune SO-36]
ATGAATAGATTACTATTGGATACTCATGCTTTTATCTGGTTTGTCTCTAATGATGCCACCCTGCCAGTGTTAACTAGAGA
AAAAATTGAATCTGCTGAGGCTGTTTTCTTTAGTATTGCAAGTCTGTGGGAAATGGCGATTAAACTCAACATTGGAAAAC
TATCCCTACAGGGTGCTTTTGAAGAGATTGAACCTAAGAGAACTCCACAGAATAATTGA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8863.20 Da        Isoelectric Point: 4.3803

>AT40690 WP_251959719.1 NZ_AP025732:2748116-2748343 [Nostoc cf. commune SO-36]
MIQPVILEKLEELPESLQTEVLHYIEFLIEKHAQNSTEEKQTNKRRVAGTMKGMFVLPLPNDFDEPLQDMKEYME

Download         Length: 228 bp

>AT40690 NZ_AP025732:2748116-2748343 [Nostoc cf. commune SO-36]
ATGATACAGCCAGTCATTTTAGAAAAATTAGAAGAACTCCCTGAGTCTCTTCAGACAGAAGTGCTTCATTACATTGAGTT
TTTAATAGAGAAGCACGCTCAAAACTCTACCGAAGAAAAGCAGACAAACAAGCGTCGCGTTGCTGGAACGATGAAAGGAA
TGTTTGTTCTGCCATTGCCTAATGACTTTGATGAGCCGCTTCAAGATATGAAAGAATATATGGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References