Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 5935836..5936530 Replicon chromosome
Accession NZ_AP025730
Organism Sphaerotilus sp. FB-5

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag NGK70_RS25755 Protein ID WP_251971273.1
Coordinates 5936102..5936530 (+) Length 143 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag NGK70_RS25750 Protein ID WP_251971272.1
Coordinates 5935836..5936102 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NGK70_RS25730 (CATMQ487_51120) 5932036..5932980 - 945 WP_251971268.1 hypothetical protein -
NGK70_RS25735 (CATMQ487_51130) 5933162..5933734 - 573 WP_251971269.1 LemA family protein -
NGK70_RS25740 (CATMQ487_51140) 5933724..5934452 - 729 WP_251971270.1 7-cyano-7-deazaguanine synthase QueC -
NGK70_RS25745 (CATMQ487_51150) 5934463..5935743 - 1281 WP_251971271.1 glutamate-5-semialdehyde dehydrogenase -
NGK70_RS25750 (CATMQ487_51160) 5935836..5936102 + 267 WP_251971272.1 CopG family transcriptional regulator Antitoxin
NGK70_RS25755 (CATMQ487_51170) 5936102..5936530 + 429 WP_251971273.1 PIN domain-containing protein Toxin
NGK70_RS25760 (CATMQ487_51180) 5936570..5937592 - 1023 WP_251971274.1 UDP-glucose 4-epimerase GalE -
NGK70_RS25765 (CATMQ487_51190) 5937739..5938287 + 549 WP_251971275.1 hypothetical protein -
NGK70_RS25770 (CATMQ487_51200) 5938328..5939893 + 1566 WP_251971276.1 ubiquinone biosynthesis regulatory protein kinase UbiB -
NGK70_RS25775 (CATMQ487_51210) 5940026..5941489 + 1464 WP_251971277.1 sodium:solute symporter family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-126)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 143 a.a.        Molecular weight: 15753.10 Da        Isoelectric Point: 7.5956

>T40684 WP_251971273.1 NZ_AP025730:5936102-5936530 [Sphaerotilus sp. FB-5]
MRALLDVNVLIAVHDADHIHHTRALAWLATEVRHGWASCPLTQNGCLRIMSQPGYVNPAPLAQVTAMLQRSTATRHHAFW
PDDLSVLDAQSFDHAQVHGHRQLTDLYLLGLAVRHGGRLVTFDQRIPLSAVRGACPEHLVVL

Download         Length: 429 bp

>T40684 NZ_AP025730:5936102-5936530 [Sphaerotilus sp. FB-5]
ATGCGAGCCCTGCTCGACGTGAATGTACTCATCGCCGTTCACGATGCGGACCACATTCACCACACCCGCGCACTGGCCTG
GCTGGCCACCGAAGTCCGCCACGGCTGGGCCAGTTGCCCACTGACGCAAAACGGTTGCCTGCGCATCATGAGTCAGCCGG
GATACGTCAACCCGGCTCCGTTGGCGCAGGTCACGGCCATGCTGCAGCGCTCGACCGCCACGCGGCACCACGCCTTCTGG
CCGGACGATCTGAGCGTGCTGGATGCGCAGTCCTTCGACCATGCCCAGGTGCACGGCCACCGCCAACTGACCGATCTCTA
CTTGCTCGGCTTGGCCGTGCGGCACGGCGGGCGCCTCGTCACCTTCGACCAGCGCATACCGCTGTCGGCCGTGCGCGGGG
CCTGCCCGGAACACCTCGTCGTGCTGTAG

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9369.67 Da        Isoelectric Point: 4.5408

>AT40684 WP_251971272.1 NZ_AP025730:5935836-5936102 [Sphaerotilus sp. FB-5]
MRTTLDIADDVLYAARELSRRQKKSLGQVISELARQAFAGQAARQSGAAVLAEPAGDYLAVLGIEPLPPRGGVVSPDLIE
RLLDDEAP

Download         Length: 267 bp

>AT40684 NZ_AP025730:5935836-5936102 [Sphaerotilus sp. FB-5]
ATGCGAACCACCCTCGACATCGCCGACGACGTGCTCTACGCAGCGCGCGAGTTGTCGCGCCGCCAGAAGAAGTCGTTGGG
GCAAGTCATTTCCGAATTGGCGCGTCAGGCCTTCGCCGGACAGGCTGCCCGGCAGTCTGGTGCTGCTGTGCTCGCGGAAC
CGGCGGGCGACTACCTTGCGGTCCTGGGCATAGAGCCCTTGCCGCCGCGCGGGGGCGTGGTCAGCCCGGATCTGATCGAG
CGCCTGCTGGACGACGAGGCGCCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References