Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PumAB/upstrm_HI1419-dnstrm_HI1420
Location 5313173..5313777 Replicon chromosome
Accession NZ_AP025730
Organism Sphaerotilus sp. FB-5

Toxin (Protein)


Gene name PumA Uniprot ID -
Locus tag NGK70_RS22845 Protein ID WP_251970749.1
Coordinates 5313173..5313469 (+) Length 99 a.a.

Antitoxin (Protein)


Gene name PumB Uniprot ID -
Locus tag NGK70_RS22850 Protein ID WP_251970750.1
Coordinates 5313466..5313777 (+) Length 104 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NGK70_RS22825 (CATMQ487_45330) 5308918..5309700 - 783 WP_251970745.1 SDR family NAD(P)-dependent oxidoreductase -
NGK70_RS22830 (CATMQ487_45340) 5310013..5310534 + 522 WP_251970746.1 SCP2 sterol-binding domain-containing protein -
NGK70_RS22835 (CATMQ487_45350) 5310585..5312129 + 1545 WP_251970747.1 2Fe-2S iron-sulfur cluster-binding protein -
NGK70_RS22840 (CATMQ487_45360) 5312157..5313035 - 879 WP_251970748.1 transposase -
NGK70_RS22845 (CATMQ487_45370) 5313173..5313469 + 297 WP_251970749.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
NGK70_RS22850 (CATMQ487_45380) 5313466..5313777 + 312 WP_251970750.1 putative addiction module antidote protein Antitoxin
NGK70_RS22855 (CATMQ487_45390) 5313774..5314004 + 231 WP_251970751.1 addiction module protein -
NGK70_RS22860 (CATMQ487_45400) 5314236..5314460 - 225 WP_251970752.1 addiction module protein -
NGK70_RS22865 (CATMQ487_45420) 5315071..5315994 - 924 WP_251970753.1 hypothetical protein -
NGK70_RS22870 (CATMQ487_45430) 5316140..5317195 - 1056 WP_251970754.1 2-oxoacid:ferredoxin oxidoreductase subunit beta -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(1-96)

Antitoxin

Uncharacterized protein HI1420

(3-97)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11248.89 Da        Isoelectric Point: 10.3620

>T40683 WP_251970749.1 NZ_AP025730:5313173-5313469 [Sphaerotilus sp. FB-5]
MIEIRKTQLYQQWFDGLRDKATRLRLEARVRRLSLGNPGQHRVLTGGVTEMKLDHGPGYRVYYAQRGSELVLLLVGGDKA
SQQRDIDTAVQLAKEWQP

Download         Length: 297 bp

>T40683 NZ_AP025730:5313173-5313469 [Sphaerotilus sp. FB-5]
ATGATCGAGATCCGCAAGACGCAGCTCTATCAGCAGTGGTTCGACGGACTGCGGGACAAAGCAACCCGTCTGCGTCTGGA
GGCTAGGGTGCGCCGGCTTTCGCTGGGCAACCCAGGGCAGCACCGGGTGCTCACGGGCGGCGTCACGGAGATGAAGCTCG
ACCACGGCCCCGGATACCGGGTGTACTACGCACAGCGCGGCAGCGAACTTGTGTTGCTGCTGGTCGGCGGCGACAAGGCC
AGCCAGCAGCGCGACATCGACACCGCCGTGCAACTGGCCAAGGAGTGGCAGCCATGA

Antitoxin


Download         Length: 104 a.a.        Molecular weight: 10922.45 Da        Isoelectric Point: 4.3719

>AT40683 WP_251970750.1 NZ_AP025730:5313466-5313777 [Sphaerotilus sp. FB-5]
MTLETTKWDVQDSLQTPEDCALYIQAALEEAGDDPAYMAAVLGDVARSRGMAQTARAAGLTREGLYKAVGPDGNPSYATM
VKILRALGLRFSVVAVPGVEMTS

Download         Length: 312 bp

>AT40683 NZ_AP025730:5313466-5313777 [Sphaerotilus sp. FB-5]
ATGACCCTCGAAACGACGAAGTGGGATGTGCAGGACAGCCTGCAGACCCCCGAAGACTGCGCGCTGTACATCCAGGCGGC
ACTCGAAGAAGCGGGCGACGACCCCGCCTACATGGCCGCCGTGCTGGGTGACGTGGCCCGCTCCCGCGGCATGGCGCAGA
CCGCCCGTGCCGCCGGGCTCACCCGCGAGGGGCTATACAAGGCAGTCGGGCCCGATGGCAACCCGAGCTACGCCACCATG
GTCAAGATCCTGCGCGCCCTGGGGCTGCGCTTCAGCGTGGTGGCGGTGCCGGGCGTGGAAATGACGTCATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References