Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 5063436..5064223 Replicon chromosome
Accession NZ_AP025730
Organism Sphaerotilus sp. FB-5

Toxin (Protein)


Gene name TacT2 Uniprot ID -
Locus tag NGK70_RS21675 Protein ID WP_251970538.1
Coordinates 5063720..5064223 (+) Length 168 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID -
Locus tag NGK70_RS21670 Protein ID WP_251970537.1
Coordinates 5063436..5063723 (+) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NGK70_RS21660 (CATMQ487_43070) 5060805..5061818 - 1014 WP_251969112.1 transposase -
NGK70_RS21665 5061882..5062835 - 954 WP_251970536.1 hypothetical protein -
NGK70_RS21670 (CATMQ487_43080) 5063436..5063723 + 288 WP_251970537.1 DUF1778 domain-containing protein Antitoxin
NGK70_RS21675 (CATMQ487_43090) 5063720..5064223 + 504 WP_251970538.1 GNAT family N-acetyltransferase Toxin
NGK70_RS21680 (CATMQ487_43100) 5064228..5064602 + 375 WP_251970539.1 hypothetical protein -
NGK70_RS21685 (CATMQ487_43110) 5064622..5065008 + 387 WP_251970540.1 DUF488 family protein -
NGK70_RS21690 (CATMQ487_43120) 5065045..5065479 - 435 WP_251970541.1 hypothetical protein -
NGK70_RS21695 (CATMQ487_43130) 5065561..5068002 - 2442 WP_251970542.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(79-143)

Antitoxin

Vibrio phage ICP1, Orf50

(6-94)


Sequences

Toxin        


Download         Length: 168 a.a.        Molecular weight: 17991.59 Da        Isoelectric Point: 8.5282

>T40682 WP_251970538.1 NZ_AP025730:5063720-5064223 [Sphaerotilus sp. FB-5]
VRLAAPEPLGNRHVVGEFDCGVASLNEWLKRRAAQNQLSGATRTFVAADLDSHQVGAYYALASSAITPDRATGRFRRNMP
DPIPVVVLARLAIDNRCQGQGLGRALFQDAARRVLHAGEAIGIRGLIVHALSDEARDFYLKIGLDPSPLEPLTLMTTIAD
LRAALGN

Download         Length: 504 bp

>T40682 NZ_AP025730:5063720-5064223 [Sphaerotilus sp. FB-5]
GTGAGGCTGGCCGCCCCCGAGCCGCTGGGGAATCGGCATGTCGTCGGGGAGTTCGACTGCGGGGTGGCGTCACTCAACGA
GTGGCTGAAACGGCGCGCCGCACAGAATCAGCTCAGCGGTGCGACCCGCACCTTTGTCGCTGCCGACCTCGACAGCCACC
AGGTGGGCGCCTACTACGCGCTCGCTTCGAGCGCGATCACACCCGACAGGGCCACGGGTCGGTTCCGGCGCAACATGCCC
GACCCCATCCCCGTCGTCGTGCTCGCACGGCTGGCCATCGACAACCGTTGCCAGGGGCAGGGGCTCGGCCGGGCCTTGTT
TCAGGACGCTGCGCGACGAGTGCTTCACGCGGGTGAGGCGATCGGCATCCGCGGCCTCATCGTGCATGCGCTGTCGGACG
AGGCGCGTGATTTCTATCTGAAAATCGGCCTGGACCCGTCGCCCCTGGAGCCGCTGACCTTGATGACCACGATCGCGGAT
CTGCGCGCGGCGTTGGGGAACTGA

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10395.79 Da        Isoelectric Point: 6.3058

>AT40682 WP_251970537.1 NZ_AP025730:5063436-5063723 [Sphaerotilus sp. FB-5]
MPTADNAPRRDALNLRIAPAERNLIDRAAASLGVTRTDFILGAARRAAEDALLDRSVMAVSPEAYAEFLARLDVPAQPNE
RLRQTMQSPSPWAQP

Download         Length: 288 bp

>AT40682 NZ_AP025730:5063436-5063723 [Sphaerotilus sp. FB-5]
ATGCCCACCGCCGACAACGCCCCCCGCCGTGACGCCCTCAACCTGCGCATCGCGCCCGCCGAGCGCAACCTGATCGACCG
GGCGGCGGCCTCGCTGGGGGTCACGCGCACGGACTTCATCCTGGGTGCGGCGCGCCGGGCGGCCGAGGATGCGCTGCTCG
ACCGCTCTGTGATGGCGGTTTCGCCCGAGGCCTATGCAGAGTTCCTGGCCCGGCTCGACGTGCCCGCGCAGCCCAATGAA
CGGCTGCGCCAGACGATGCAGAGCCCCTCGCCCTGGGCGCAGCCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References