Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-StbC
Location 3178739..3179418 Replicon chromosome
Accession NZ_AP025730
Organism Sphaerotilus sp. FB-5

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag NGK70_RS13770 Protein ID WP_251969104.1
Coordinates 3178739..3179161 (-) Length 141 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag NGK70_RS13775 Protein ID WP_251969105.1
Coordinates 3179158..3179418 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NGK70_RS13745 (CATMQ487_27160) 3173974..3174831 + 858 WP_251969101.1 undecaprenyl-diphosphate phosphatase -
NGK70_RS13750 (CATMQ487_27170) 3174815..3175459 - 645 WP_251973781.1 tRNA (guanosine(46)-N7)-methyltransferase TrmB -
NGK70_RS13755 (CATMQ487_27180) 3175818..3177374 + 1557 WP_251969102.1 D-alanyl-D-alanine carboxypeptidase/D-alanyl-D-alanine-endopeptidase -
NGK70_RS13765 (CATMQ487_27190) 3177637..3178626 - 990 WP_251969103.1 S-4TM family putative pore-forming effector -
NGK70_RS13770 (CATMQ487_27200) 3178739..3179161 - 423 WP_251969104.1 type II toxin-antitoxin system VapC family toxin Toxin
NGK70_RS13775 (CATMQ487_27210) 3179158..3179418 - 261 WP_251969105.1 plasmid stabilization protein Antitoxin
NGK70_RS13780 (CATMQ487_27220) 3180656..3180943 - 288 WP_251969106.1 CRISPR-associated endonuclease Cas2 -
NGK70_RS13785 (CATMQ487_27230) 3180949..3183312 - 2364 WP_251969107.1 CRISPR-associated endonuclease Cas1 -
NGK70_RS13790 (CATMQ487_27240) 3183354..3183656 - 303 WP_251969108.1 CRISPR-associated endonuclease Cas2 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-123)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 141 a.a.        Molecular weight: 14786.03 Da        Isoelectric Point: 5.1170

>T40679 WP_251969104.1 NZ_AP025730:c3179161-3178739 [Sphaerotilus sp. FB-5]
MIVLDTNVLSEAMKPQPDPAVLAWLDAQAADTLYLTSVTLAELWFGIGAMPAGRRREALARTLEGLLPLFEGRILPFDTE
AARHYAQLAVAARAAGRGLPTPDGYIAAMAAARGFAVATRDAAPFKAAGQEVINPWAASP

Download         Length: 423 bp

>T40679 NZ_AP025730:c3179161-3178739 [Sphaerotilus sp. FB-5]
ATGATCGTCCTGGACACCAACGTACTCTCCGAGGCCATGAAGCCGCAGCCCGACCCAGCCGTGCTGGCCTGGCTGGACGC
GCAGGCGGCCGACACCTTGTACCTCACCAGCGTCACCCTGGCCGAACTGTGGTTTGGCATCGGCGCCATGCCGGCGGGCC
GGCGCAGGGAGGCCCTGGCGCGAACGCTGGAGGGACTGCTGCCGCTGTTCGAGGGGCGCATCCTGCCCTTCGACACCGAG
GCGGCACGCCACTACGCGCAGCTGGCGGTGGCCGCCCGTGCTGCCGGGCGCGGCCTGCCCACGCCGGACGGCTACATCGC
CGCCATGGCCGCTGCACGCGGCTTTGCCGTGGCCACCCGCGATGCGGCTCCGTTCAAGGCGGCGGGACAGGAAGTCATCA
ACCCCTGGGCCGCTTCACCCTGA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9482.90 Da        Isoelectric Point: 7.2062

>AT40679 WP_251969105.1 NZ_AP025730:c3179418-3179158 [Sphaerotilus sp. FB-5]
MPTLTVRNLPDEVHRALRLRAAQHGRSTEAEVRDILDATVRPPQRLRLGAAMAEVSRRAGLLNEDVLALEALTAERQAPA
QPLVLE

Download         Length: 261 bp

>AT40679 NZ_AP025730:c3179418-3179158 [Sphaerotilus sp. FB-5]
ATGCCCACCCTCACCGTCCGCAACCTGCCCGATGAAGTGCACCGCGCACTGCGATTGCGGGCAGCGCAGCATGGCCGCAG
CACGGAGGCGGAGGTCCGCGACATCCTGGATGCCACCGTGCGCCCACCGCAGCGCCTGCGCCTGGGTGCCGCGATGGCAG
AGGTGAGCCGGCGCGCCGGCCTGCTCAATGAGGATGTGCTCGCGCTGGAAGCGCTGACGGCCGAACGCCAGGCACCCGCC
CAACCGCTGGTGCTGGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References