Detailed information of TA system TA040678

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-VagC
• Location: 3065008..3065678
• Replicon: chromosome
• Accession: NZ_AP025730
• Organism: Sphaerotilus sp. FB-5

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: NGK70_RS13310
• Protein ID: WP_251969026.1
• Coordinates: 3065241..3065678 (+)
• Length: 146 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: NGK70_RS13305
• Protein ID: WP_251969025.1
• Coordinates: 3065008..3065241 (+)
• Length: 78 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
NGK70_RS13290 (CATMQ487_26270)	3061137..3062657	+	1521	WP_251969022.1	aldehyde dehydrogenase family protein	-
NGK70_RS13295 (CATMQ487_26280)	3063315..3064394	-	1080	WP_251969023.1	MBL fold metallo-hydrolase	-
NGK70_RS13300 (CATMQ487_26290)	3064405..3064602	-	198	WP_251969024.1	hypothetical protein	-
NGK70_RS13305 (CATMQ487_26300)	3065008..3065241	+	234	WP_251969025.1	AbrB/MazE/SpoVT family DNA-binding domain-containing protein	Antitoxin
NGK70_RS13310 (CATMQ487_26310)	3065241..3065678	+	438	WP_251969026.1	type II toxin-antitoxin system VapC family toxin	Toxin

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (13-133)

Antitoxin

• SpoVT-AbrB domain (9-45)

Sequences

Toxin

Protein

• Length: 146 a.a.
• Molecular weight: 15914.20 Da
• Isoelectric Point: 6.8532

>T40678 WP_251969026.1 NZ_AP025730:3065241-3065678 [Sphaerotilus sp. FB-5]
MAATQPQPRARLYMLDTNALYELVRNPHGPLAQKLNTLEPDTVCTSIVAACELRFGAERKASAPLTQRVDQLLRALTVLP
LDTPADEHYADIRATLECSGIPGGNHDLFIAAHARSRGMTLLTRNLREFQRVPGLTVEDWPTGAA

Nucleotide

• Length: 438 bp

>T40678 NZ_AP025730:3065241-3065678 [Sphaerotilus sp. FB-5]
ATGGCTGCTACTCAACCGCAGCCGCGCGCGCGGCTCTACATGCTCGATACGAATGCGCTCTACGAGCTAGTTCGCAACCC
TCACGGCCCCCTGGCCCAGAAACTGAACACGCTTGAGCCCGATACTGTTTGCACCAGCATCGTCGCGGCGTGTGAACTTC
GCTTTGGCGCAGAGCGCAAGGCCTCGGCACCGCTCACGCAGCGGGTGGATCAGTTGTTGCGGGCGCTGACCGTGCTGCCG
CTGGACACGCCGGCCGACGAGCACTACGCCGACATCCGCGCCACGCTGGAGTGCAGCGGCATCCCCGGCGGCAACCACGA
CTTGTTCATCGCGGCCCATGCGCGCTCACGCGGCATGACTCTGCTCACGCGAAACCTGCGGGAGTTCCAGCGTGTGCCGG
GATTGACCGTCGAGGACTGGCCGACCGGCGCGGCGTAG

Antitoxin

Protein

• Length: 78 a.a.
• Molecular weight: 8696.01 Da
• Isoelectric Point: 7.2056

>AT40678 WP_251969025.1 NZ_AP025730:3065008-3065241 [Sphaerotilus sp. FB-5]
VTERHAALFRNGRNQAVRIPRELEMEGSEVLIRKEGDSLILTPIRKHKLRDLLASWTPMDGALPELEDLPPQSRGGL

Nucleotide

• Length: 234 bp

>AT40678 NZ_AP025730:3065008-3065241 [Sphaerotilus sp. FB-5]
GTGACCGAGCGCCACGCCGCGTTGTTTCGCAACGGCCGCAACCAGGCGGTCCGGATTCCGCGAGAACTGGAGATGGAAGG
TTCCGAGGTGCTGATTCGCAAGGAGGGCGACAGCCTTATCCTGACCCCCATCCGCAAGCACAAGCTGCGCGACCTGCTTG
CGTCGTGGACCCCGATGGATGGCGCTCTGCCCGAGCTGGAAGACCTACCGCCACAGTCCAGGGGGGGCCTGTGA