Detailed information of TA system TA040677

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): slvAT/RES(toxin)
• Location: 2888640..2889541
• Replicon: chromosome
• Accession: NZ_AP025730
• Organism: Sphaerotilus sp. FB-5

Toxin (Protein)

• Gene name: slvT
• Uniprot ID: -
• Locus tag: NGK70_RS12560
• Protein ID: WP_251973534.1
• Coordinates: 2889041..2889541 (+)
• Length: 167 a.a.

Antitoxin (Protein)

• Gene name: slvA
• Uniprot ID: -
• Locus tag: NGK70_RS12555
• Protein ID: WP_251973533.1
• Coordinates: 2888640..2889011 (+)
• Length: 124 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
NGK70_RS12535 (CATMQ487_24750)	2884206..2885303	+	1098	WP_251973530.1	tRNA dihydrouridine(20/20a) synthase DusA	-
NGK70_RS12540 (CATMQ487_24760)	2885320..2886552	+	1233	WP_251973531.1	GGDEF domain-containing protein	-
NGK70_RS12545 (CATMQ487_24770)	2886710..2887642	+	933	WP_251973765.1	alpha/beta hydrolase	-
NGK70_RS12550 (CATMQ487_24780)	2887677..2888555	+	879	WP_251973532.1	YbgC/FadM family acyl-CoA thioesterase	-
NGK70_RS12555 (CATMQ487_24790)	2888640..2889011	+	372	WP_251973533.1	DUF2384 domain-containing protein	Antitoxin
NGK70_RS12560 (CATMQ487_24800)	2889041..2889541	+	501	WP_251973534.1	RES family NAD+ phosphorylase	Toxin
NGK70_RS12565 (CATMQ487_24810)	2889519..2891519	-	2001	WP_251973535.1	SDR family oxidoreductase	-
NGK70_RS12570 (CATMQ487_24820)	2891812..2892339	+	528	WP_251973536.1	phasin family protein	-
NGK70_RS12575 (CATMQ487_24830)	2892550..2893809	+	1260	WP_251973537.1	patatin-like phospholipase family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• RES domain (3-155)

Antitoxin

• Antitoxin Xre/MbcA/ParS-like, toxin-binding domain (70-120)

Sequences

Toxin

Protein

• Length: 167 a.a.
• Molecular weight: 18023.34 Da
• Isoelectric Point: 6.2933

>T40677 WP_251973534.1 NZ_AP025730:2889041-2889541 [Sphaerotilus sp. FB-5]
MACWRVISPAYAGTPLSGMGAARQGGRFNRPGQEALYLSLDESTALAEYRQDNPWLPAGIICTFLVRGLRVADLSARFDP
GRWPALWSDFASDWRALWFGDAIEPPTWYMADDVVAAGWDGIVFPSQARPGGRNLVIYGSSGRPATQLAVYDPTGSLARL
RSGSPS

Nucleotide

• Length: 501 bp

>T40677 NZ_AP025730:2889041-2889541 [Sphaerotilus sp. FB-5]
ATGGCCTGCTGGCGTGTCATTTCCCCCGCCTACGCGGGCACGCCCCTGTCCGGCATGGGTGCGGCGAGGCAGGGCGGGCG
GTTCAACCGGCCGGGCCAGGAGGCGCTGTACCTGTCACTGGACGAGTCCACCGCCCTGGCCGAATACCGCCAGGACAACC
CTTGGCTGCCAGCGGGCATCATATGTACCTTCCTTGTGCGGGGCCTGCGGGTGGCGGACCTGAGTGCCCGCTTCGACCCC
GGGCGCTGGCCTGCGCTGTGGAGCGACTTTGCTTCGGACTGGCGTGCTCTGTGGTTCGGCGACGCCATCGAGCCACCCAC
CTGGTACATGGCCGATGACGTTGTGGCCGCCGGGTGGGATGGCATCGTCTTCCCTTCCCAGGCGCGCCCGGGCGGCCGCA
ATCTGGTGATCTACGGCAGTTCGGGCAGGCCTGCGACGCAGTTGGCTGTCTACGACCCCACGGGCAGCCTTGCCCGCCTT
AGAAGTGGATCCCCTTCATGA

Antitoxin

Protein

• Length: 124 a.a.
• Molecular weight: 13629.55 Da
• Isoelectric Point: 8.4939

>AT40677 WP_251973533.1 NZ_AP025730:2888640-2889011 [Sphaerotilus sp. FB-5]
MSAVLKQPLVERFREPDTPYLSPTRVGDFFGFRVQELAERAHVHRNTPTARPQAPQLQKYLQDMLRVLAAATEMTGDAER
AAFLLRNEPLRAFGYKTADALVQEGRTEALIAYLQSLAGGAAG

Nucleotide

• Length: 372 bp

>AT40677 NZ_AP025730:2888640-2889011 [Sphaerotilus sp. FB-5]
ATGTCTGCCGTCCTGAAACAACCCCTTGTCGAGCGGTTCCGCGAGCCCGACACACCCTACCTGTCCCCGACGAGGGTGGG
GGACTTCTTTGGTTTTCGCGTCCAGGAACTGGCTGAGCGGGCGCATGTGCACCGCAACACACCCACTGCACGCCCGCAGG
CGCCGCAACTGCAAAAGTACCTGCAGGACATGCTGCGTGTGCTCGCCGCCGCGACGGAGATGACCGGCGATGCCGAACGC
GCCGCCTTTCTGCTGCGCAATGAGCCCCTTCGCGCCTTCGGCTACAAGACCGCCGATGCGCTTGTACAGGAGGGGCGCAC
CGAGGCGCTCATCGCCTACCTGCAGTCGTTGGCCGGCGGTGCCGCGGGATGA