Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/upstrm_HI1419-dnstrm_HI1420
Location 1677186..1677794 Replicon chromosome
Accession NZ_AP025730
Organism Sphaerotilus sp. FB-5

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag NGK70_RS07440 Protein ID WP_251972622.1
Coordinates 1677498..1677794 (-) Length 99 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag NGK70_RS07435 Protein ID WP_251972621.1
Coordinates 1677186..1677494 (-) Length 103 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NGK70_RS07415 (CATMQ487_14730) 1672284..1673021 + 738 WP_251972617.1 SDR family oxidoreductase -
NGK70_RS07420 (CATMQ487_14740) 1673037..1674467 - 1431 WP_251972618.1 TRAFs-binding domain-containing protein -
NGK70_RS07425 (CATMQ487_14750) 1674694..1675659 - 966 WP_251972619.1 caspase family protein -
NGK70_RS07430 (CATMQ487_14770) 1676054..1676659 - 606 WP_251972620.1 recombinase family protein -
NGK70_RS07435 (CATMQ487_14780) 1677186..1677494 - 309 WP_251972621.1 putative addiction module antidote protein Antitoxin
NGK70_RS07440 (CATMQ487_14790) 1677498..1677794 - 297 WP_251972622.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
NGK70_RS07445 (CATMQ487_14800) 1677908..1678267 - 360 WP_251972623.1 hypothetical protein -
NGK70_RS07450 (CATMQ487_14810) 1678258..1680048 - 1791 WP_251972624.1 DUF927 domain-containing protein -
NGK70_RS07455 (CATMQ487_14820) 1680450..1681544 - 1095 Protein_1472 toprim domain-containing protein -
NGK70_RS07460 (CATMQ487_14830) 1681554..1682108 - 555 WP_251972625.1 hypothetical protein -
NGK70_RS07465 (CATMQ487_14840) 1682200..1682562 - 363 WP_251972626.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 1670018..1694254 24236
- flank IS/Tn - - 1676054..1676659 605


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(1-96)

Antitoxin

Uncharacterized protein HI1420

(13-99)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11029.73 Da        Isoelectric Point: 10.0414

>T40674 WP_251972622.1 NZ_AP025730:c1677794-1677498 [Sphaerotilus sp. FB-5]
MYTVRQTPEFMQWLTGLKDGMTRRRLARRLEKVQRGNLGDVKAVGEGVCEMRESFGPGWRMYYVQRGAVLVLMLGGGDKS
TQQADIAAAQALARHIED

Download         Length: 297 bp

>T40674 NZ_AP025730:c1677794-1677498 [Sphaerotilus sp. FB-5]
ATGTACACGGTCCGGCAAACCCCCGAGTTCATGCAGTGGCTGACCGGCCTGAAGGACGGCATGACCCGGCGCCGCCTGGC
GCGCCGACTGGAAAAGGTGCAACGCGGCAACCTGGGCGACGTGAAGGCTGTCGGCGAGGGGGTGTGCGAGATGCGCGAGT
CCTTTGGCCCCGGGTGGCGCATGTACTACGTTCAGCGCGGCGCCGTGTTGGTCTTGATGCTGGGCGGGGGCGACAAGAGC
ACCCAGCAAGCCGACATTGCAGCGGCGCAGGCCCTGGCGCGGCACATTGAGGATTGA

Antitoxin


Download         Length: 103 a.a.        Molecular weight: 10882.44 Da        Isoelectric Point: 4.6290

>AT40674 WP_251972621.1 NZ_AP025730:c1677494-1677186 [Sphaerotilus sp. FB-5]
MSDTKTIKASDLPEFDMAEHLDSDQAIAEYLTIVLEEDDPAALADALGTIARARGMTAVAADAGLTREALYKALRPTAHP
RFDTIQRVCKALGVKLVAQVAA

Download         Length: 309 bp

>AT40674 NZ_AP025730:c1677494-1677186 [Sphaerotilus sp. FB-5]
ATGAGCGACACCAAGACGATCAAGGCTTCTGACCTGCCAGAGTTCGACATGGCGGAGCACCTGGACAGCGATCAGGCGAT
CGCCGAATACCTCACCATCGTGCTTGAAGAGGACGACCCGGCGGCCCTGGCCGATGCGCTCGGAACGATTGCCCGCGCCC
GTGGCATGACGGCTGTCGCGGCCGATGCGGGCCTGACCCGCGAAGCCCTTTACAAGGCGCTGCGGCCGACGGCACATCCG
CGCTTCGACACGATTCAACGGGTGTGCAAGGCGCTGGGGGTCAAGCTGGTGGCGCAGGTGGCCGCCTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References