Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pasABC/RelE-HTH
Location 242687..243167 Replicon chromosome
Accession NZ_AP025730
Organism Sphaerotilus sp. FB-5

Toxin (Protein)


Gene name pasB Uniprot ID -
Locus tag NGK70_RS01105 Protein ID WP_251971550.1
Coordinates 242898..243167 (+) Length 90 a.a.

Antitoxin (Protein)


Gene name pasA Uniprot ID -
Locus tag NGK70_RS01100 Protein ID WP_251971549.1
Coordinates 242687..242914 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NGK70_RS01075 (CATMQ487_02110) 237695..238684 + 990 WP_251971544.1 alpha/beta hydrolase -
NGK70_RS01080 (CATMQ487_02120) 238709..239434 - 726 WP_251971545.1 FCD domain-containing protein -
NGK70_RS01085 (CATMQ487_02130) 239572..240375 + 804 WP_251971546.1 (Fe-S)-binding protein -
NGK70_RS01090 (CATMQ487_02140) 240402..241136 + 735 WP_251971547.1 lactate utilization protein C -
NGK70_RS01095 (CATMQ487_02150) 241133..242638 + 1506 WP_251971548.1 LutB/LldF family L-lactate oxidation iron-sulfur protein -
NGK70_RS01100 (CATMQ487_02160) 242687..242914 + 228 WP_251971549.1 ribbon-helix-helix protein, CopG family Antitoxin
NGK70_RS01105 (CATMQ487_02170) 242898..243167 + 270 WP_251971550.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
NGK70_RS01110 (CATMQ487_02180) 243208..244080 - 873 WP_251971551.1 hypothetical protein -
NGK70_RS01115 (CATMQ487_02190) 244364..244774 + 411 WP_251971552.1 hypothetical protein -
NGK70_RS01120 (CATMQ487_02200) 244784..245942 - 1159 Protein_218 glycerate kinase -
NGK70_RS01125 (CATMQ487_02210) 245942..246745 - 804 Protein_219 tripartite tricarboxylate transporter substrate binding protein -
NGK70_RS01130 (CATMQ487_02220) 246733..247503 - 771 Protein_220 isocitrate/isopropylmalate family dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-88)

Antitoxin

Ribbon-helix-helix protein, CopG

(3-39)


Sequences

Toxin        


Download         Length: 90 a.a.        Molecular weight: 10238.91 Da        Isoelectric Point: 11.3201

>T40671 WP_251971550.1 NZ_AP025730:242898-243167 [Sphaerotilus sp. FB-5]
MAWRIELTATAARQLGKLDKAQARRITTFLRQRLATLDDPRGAGKALTGPQLGSFWRYRVGDYRLICDVQDGVLRILVIE
IGHRREVYR

Download         Length: 270 bp

>T40671 NZ_AP025730:242898-243167 [Sphaerotilus sp. FB-5]
TTGGCCTGGCGGATTGAGCTGACGGCCACCGCCGCCAGGCAACTGGGCAAACTGGACAAGGCCCAGGCCCGCCGGATCAC
CACCTTCCTGCGCCAGCGGCTGGCCACGCTGGACGATCCCCGAGGCGCCGGCAAGGCGCTGACCGGCCCACAGCTCGGTT
CGTTCTGGCGCTACCGGGTGGGCGACTACCGGCTGATCTGCGACGTTCAGGATGGGGTGCTGCGCATCCTGGTGATCGAG
ATCGGGCACCGGCGCGAGGTGTATCGCTGA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8325.27 Da        Isoelectric Point: 4.1958

>AT40671 WP_251971549.1 NZ_AP025730:242687-242914 [Sphaerotilus sp. FB-5]
MPTSIRLDPAIEQRLDHLAAATGRSKAFYLRELIANGLDDLEDYYLAAATAQRVREGTEAVYSLDEVERDLGLAD

Download         Length: 228 bp

>AT40671 NZ_AP025730:242687-242914 [Sphaerotilus sp. FB-5]
ATGCCCACCTCCATCCGGCTCGACCCCGCCATCGAGCAGCGCCTGGACCACCTGGCTGCCGCGACCGGCCGCAGCAAGGC
GTTCTACCTGCGCGAGCTGATCGCCAACGGGCTGGACGACCTGGAGGACTACTACCTGGCCGCCGCCACCGCGCAGCGGG
TGCGCGAGGGCACGGAAGCGGTGTATTCGCTCGACGAGGTGGAGCGCGACCTTGGCCTGGCGGATTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References