40670

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE(toxin)
Location 1117089..1117582 Replicon chromosome
Accession NZ_AP025728
Organism Ligilactobacillus murinus strain YK1

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag LmYK1_RS05405 Protein ID WP_172477541.1
Coordinates 1117089..1117364 (-) Length 92 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag LmYK1_RS05410 Protein ID WP_089135834.1
Coordinates 1117361..1117582 (-) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LmYK1_RS05380 (LmYK1_10780) 1112309..1113733 + 1425 WP_089135191.1 ATP-dependent protease ATPase subunit HslU -
LmYK1_RS05385 (LmYK1_10790) 1113890..1114762 - 873 WP_172477543.1 aldose 1-epimerase family protein -
LmYK1_RS05390 (LmYK1_10800) 1114837..1115439 - 603 WP_039936077.1 glycerol-3-phosphate 1-O-acyltransferase PlsY -
LmYK1_RS05395 (LmYK1_10810) 1115534..1115827 - 294 WP_004047845.1 hypothetical protein -
LmYK1_RS05400 (LmYK1_10820) 1115998..1116825 + 828 WP_172477542.1 5'-nucleotidase, lipoprotein e(P4) family -
LmYK1_RS05405 (LmYK1_10830) 1117089..1117364 - 276 WP_172477541.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LmYK1_RS05410 (LmYK1_10840) 1117361..1117582 - 222 WP_089135834.1 DUF6290 family protein Antitoxin
LmYK1_RS05415 (LmYK1_10850) 1117742..1118704 - 963 WP_286294715.1 IS30 family transposase -
LmYK1_RS05420 (LmYK1_10860) 1118919..1120091 + 1173 WP_004050661.1 IS256 family transposase -
LmYK1_RS05425 (LmYK1_10870) 1120254..1120683 + 430 Protein_1064 tyrosine-type recombinase/integrase -
LmYK1_RS05430 (LmYK1_10880) 1120955..1121917 - 963 WP_172477239.1 LD-carboxypeptidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 1118919..1120091 1172


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-87)

Antitoxin

Protein of unknown function DUF6290

(1-71)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10931.67 Da        Isoelectric Point: 9.9233

>T40670 WP_172477541.1 NZ_AP025728:c1117364-1117089 [Ligilactobacillus murinus]
MKEYHVEYSKRAQKQIKKLDRQIQRLLFAWIDKNLEGVSDPRIHGKGLTGNHACEWRYRIGDYRLICDIQDDIMIILALE
FGHRRSVYNKK

Download         Length: 276 bp

>T40670 NZ_AP025728:c1117364-1117089 [Ligilactobacillus murinus]
TTGAAAGAATACCATGTTGAATACTCAAAAAGAGCACAAAAACAAATCAAGAAATTAGATAGACAAATTCAACGGTTGCT
ATTTGCCTGGATAGATAAAAATCTTGAAGGCGTATCTGATCCACGCATACATGGTAAAGGTTTGACTGGAAACCATGCTT
GTGAATGGAGATATAGAATTGGCGACTACCGCCTTATATGTGATATTCAAGATGACATAATGATTATCTTGGCTTTGGAA
TTTGGTCACAGAAGATCTGTGTATAATAAAAAATAA

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8574.57 Da        Isoelectric Point: 4.3566

>AT40670 WP_089135834.1 NZ_AP025728:c1117582-1117361 [Ligilactobacillus murinus]
MATISIRLNQQEEEFFKGYAELTGENLSTLFKEALKKSIDDEYDLQVYKEAYKEYQQDPVTISHADFKKELGF

Download         Length: 222 bp

>AT40670 NZ_AP025728:c1117582-1117361 [Ligilactobacillus murinus]
ATGGCTACTATTAGTATCAGGCTAAACCAACAAGAAGAAGAATTTTTTAAAGGATATGCAGAACTTACTGGAGAAAACTT
GTCTACTCTCTTCAAAGAAGCTCTTAAAAAAAGCATTGATGATGAATACGATCTTCAGGTATACAAAGAAGCATATAAAG
AGTATCAGCAAGATCCAGTAACTATCTCACATGCTGACTTTAAAAAGGAGTTAGGTTTTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References