Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazE-VapB1/MazF-VagC
Location 350450..350991 Replicon chromosome
Accession NZ_AP025696
Organism Nitrosophilus kaiyonis strain MOT50

Toxin (Protein)


Gene name mazE Uniprot ID -
Locus tag QML81_RS01785 Protein ID WP_281951478.1
Coordinates 350450..350761 (-) Length 104 a.a.

Antitoxin (Protein)


Gene name VapB1 Uniprot ID -
Locus tag QML81_RS01790 Protein ID WP_281951479.1
Coordinates 350758..350991 (-) Length 78 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QML81_RS01765 346479..347096 - 618 WP_281951474.1 lysophospholipid acyltransferase family protein -
QML81_RS01770 347161..348462 - 1302 WP_281951475.1 tRNA (N6-isopentenyl adenosine(37)-C2)-methylthiotransferase MiaB -
QML81_RS01775 348623..348868 - 246 WP_281951476.1 HP0268 family nuclease -
QML81_RS01780 349205..350323 - 1119 WP_281951477.1 transcription termination factor NusA -
QML81_RS01785 350450..350761 - 312 WP_281951478.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
QML81_RS01790 350758..350991 - 234 WP_281951479.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
QML81_RS01795 351212..352174 - 963 WP_281951480.1 ABC transporter permease -
QML81_RS01800 352426..353127 - 702 WP_281951481.1 hypothetical protein -
QML81_RS01805 353345..354610 - 1266 WP_281951482.1 porin -
QML81_RS01810 355010..355837 - 828 WP_281951483.1 enoyl-ACP reductase FabI -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(4-101)

Antitoxin

SpoVT-AbrB domain

(10-49)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12024.38 Da        Isoelectric Point: 9.8185

>T40669 WP_281951478.1 NZ_AP025696:c350761-350450 [Nitrosophilus kaiyonis]
MRYKQYEVILVNLDPTIGAEIKKTRPCVIISPDEMNFSNVIVAPMTSKYKDYPTRVKIDENSYIVLDQIRTISIKRIIKK
LDIKLSPEDIKEIKKIIKIMLVD

Download         Length: 312 bp

>T40669 NZ_AP025696:c350761-350450 [Nitrosophilus kaiyonis]
ATGAGATATAAGCAGTATGAAGTTATTTTAGTAAATTTAGATCCCACAATTGGAGCTGAAATTAAAAAAACACGGCCTTG
TGTTATTATTTCTCCAGATGAGATGAATTTTAGTAATGTTATAGTTGCTCCTATGACTTCAAAATATAAAGATTACCCTA
CAAGAGTAAAAATAGATGAAAATAGTTATATAGTATTAGATCAAATTAGAACTATTTCTATTAAAAGAATTATAAAAAAA
TTGGATATAAAACTATCACCTGAAGATATAAAAGAGATAAAAAAAATTATTAAAATAATGTTAGTTGATTAA

Antitoxin


Download         Length: 78 a.a.        Molecular weight: 9060.39 Da        Isoelectric Point: 4.4463

>AT40669 WP_281951479.1 NZ_AP025696:c350991-350758 [Nitrosophilus kaiyonis]
MEKMIEAKVFKSGNSQAIRIPKEFRVDSDIVIIEKEDDKLIITPIKKNPREGWEEKFSKSQELLIDDALDIQEWQDL

Download         Length: 234 bp

>AT40669 NZ_AP025696:c350991-350758 [Nitrosophilus kaiyonis]
ATGGAAAAAATGATCGAAGCTAAAGTATTTAAAAGTGGAAATTCTCAAGCTATTAGGATTCCTAAAGAGTTTAGAGTAGA
TAGTGATATAGTTATAATTGAAAAAGAGGATGATAAACTTATCATTACACCAATAAAGAAAAATCCAAGAGAGGGTTGGG
AAGAAAAATTTTCCAAATCTCAAGAGTTATTGATAGATGATGCTTTAGATATTCAAGAGTGGCAAGATTTATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References