Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 2212760..2213274 Replicon chromosome
Accession NZ_AP025693
Organism Staphylococcus aureus strain JICS127

Toxin (Protein)


Gene name TsdT Uniprot ID T1YA99
Locus tag M2038_RS11070 Protein ID WP_000581792.1
Coordinates 2212760..2212969 (-) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID W8UW13
Locus tag M2038_RS11075 Protein ID WP_000138932.1
Coordinates 2212981..2213274 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M2038_RS11050 (2208268) 2208268..2209626 - 1359 WP_000611462.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -
M2038_RS11055 (2209641) 2209641..2210711 - 1071 WP_000159631.1 D-alanine--D-alanine ligase -
M2038_RS11060 (2211029) 2211029..2212231 + 1203 WP_001109939.1 FtsW/RodA/SpoVE family cell cycle protein -
M2038_RS11065 (2212495) 2212495..2212632 - 138 WP_000828354.1 Lmo0850 family protein -
M2038_RS11070 (2212760) 2212760..2212969 - 210 WP_000581792.1 heavy metal-associated domain-containing protein Toxin
M2038_RS11075 (2212981) 2212981..2213274 - 294 WP_000138932.1 copper-sensing transcriptional repressor CsoR Antitoxin
M2038_RS11080 (2213440) 2213440..2214924 + 1485 WP_000571549.1 cardiolipin synthase -
M2038_RS11085 (2214952) 2214952..2215599 + 648 WP_001187629.1 HD domain-containing protein -
M2038_RS11090 (2216412) 2216412..2217284 - 873 WP_000725802.1 membrane protein insertase YidC -
M2038_RS11095 (2217370) 2217370..2218011 - 642 WP_000483153.1 thiamine phosphate synthase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(23-66)

Antitoxin

Metal-sensitive transcriptional repressor

(14-92)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7843.77 Da        Isoelectric Point: 4.1008

>T40663 WP_000581792.1 NZ_AP025693:c2212969-2212760 [Staphylococcus aureus]
MIHQNTIYTAGIETEEQVSQLTERISNMIGVHQVNINIIDGQVTVSYETPANLNSIEKEIYDEGYKIVF

Download         Length: 210 bp

>T40663 NZ_AP025693:c2212969-2212760 [Staphylococcus aureus]
ATGATACATCAAAATACGATTTACACAGCGGGAATTGAAACAGAAGAACAAGTAAGTCAATTGACAGAACGCATTTCAAA
TATGATAGGTGTTCATCAAGTGAATATTAATATAATAGATGGTCAAGTAACTGTATCGTATGAGACACCAGCAAATTTGA
ATAGTATTGAAAAAGAAATCTATGATGAAGGATACAAAATTGTATTTTAG

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11197.82 Da        Isoelectric Point: 6.2243

>AT40663 WP_000138932.1 NZ_AP025693:c2213274-2212981 [Staphylococcus aureus]
MTEQDNAHHSEQIKTNLKSRLNRIEGQVRAINRMIEEDVYCDDVLTQIRATRSALNSVAIKLLEQHMKSCIMNKVNQGAQ
EEAMEELLVTFQKLIKD

Download         Length: 294 bp

>AT40663 NZ_AP025693:c2213274-2212981 [Staphylococcus aureus]
ATGACTGAACAAGATAATGCACATCATTCTGAACAAATAAAAACGAATCTTAAATCACGTTTAAATCGAATTGAAGGACA
AGTGAGAGCGATTAATCGCATGATTGAAGAAGATGTCTATTGTGATGATGTCCTTACGCAAATAAGAGCGACACGTTCGG
CGTTAAACAGTGTTGCGATAAAGTTATTAGAACAACATATGAAAAGTTGTATTATGAATAAAGTTAATCAAGGTGCTCAG
GAAGAGGCAATGGAAGAGTTATTAGTGACTTTTCAAAAATTGATTAAAGACTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6FF1

Antitoxin

Source ID Structure
AlphaFold DB W8UW13

References