Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 887970..888447 Replicon chromosome
Accession NZ_AP025693
Organism Staphylococcus aureus strain JICS127

Toxin (Protein)


Gene name TsaT Uniprot ID Q2G005
Locus tag M2038_RS04265 Protein ID WP_000052078.1
Coordinates 887970..888158 (-) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID T1Y6P8
Locus tag M2038_RS04270 Protein ID WP_001059690.1
Coordinates 888187..888447 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M2038_RS04235 (884011) 884011..884481 + 471 WP_000824472.1 hypothetical protein -
M2038_RS04240 (884822) 884822..885508 + 687 WP_001548082.1 thermonuclease family protein -
M2038_RS04245 (885865) 885865..886065 + 201 WP_001059082.1 cold-shock protein -
M2038_RS04250 (886561) 886561..886779 - 219 WP_000005886.1 hypothetical protein -
M2038_RS04255 (886841) 886841..887125 - 285 WP_001004395.1 hypothetical protein -
M2038_RS04260 (887213) 887213..887782 - 570 WP_001106654.1 lipoprotein N-acylation protein LnsA -
M2038_RS04265 (887970) 887970..888158 - 189 WP_000052078.1 hypothetical protein Toxin
M2038_RS04270 (888187) 888187..888447 - 261 WP_001059690.1 hypothetical protein Antitoxin
M2038_RS04275 (888788) 888788..888991 + 204 WP_000145163.1 sterile alpha motif-like domain-containing protein -
M2038_RS04280 (888988) 888988..889224 - 237 WP_000368687.1 hypothetical protein -
M2038_RS04285 (889449) 889449..890030 + 582 WP_001140686.1 histidine phosphatase family protein -
M2038_RS04290 (890103) 890103..890720 - 618 WP_000255561.1 LysE/ArgO family amino acid transporter -
M2038_RS04295 (890875) 890875..891369 - 495 WP_000569884.1 GNAT family N-acetyltransferase -
M2038_RS04300 (891768) 891768..892190 - 423 WP_000974460.1 organic hydroperoxide resistance protein -
M2038_RS04305 (892338) 892338..893054 + 717 WP_000150017.1 type I 3-dehydroquinate dehydratase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - selk / selq 882654..913735 31081


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(6-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-127)


Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7172.84 Da        Isoelectric Point: 9.9971

>T40654 WP_000052078.1 NZ_AP025693:c888158-887970 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTSKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Download         Length: 189 bp

>T40654 NZ_AP025693:c888158-887970 [Staphylococcus aureus]
ATGTCTTTACATTTTGCAATTCTGTTTTGGCTAGCATTAATTTTCTTAGTTGCCGCTACGTTTATACTCGTATTAATGAA
AAAAACTAGCAAAGAATCTAAAAAAGAGTCCTATTTAAGTTTCACTGTCATTCTCTATATTTTTGGATTCGCTATATTAA
TATACACATTTATATTTGGTGTGCTATAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9940.09 Da        Isoelectric Point: 4.0624

>AT40654 WP_001059690.1 NZ_AP025693:c888447-888187 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Download         Length: 261 bp

>AT40654 NZ_AP025693:c888447-888187 [Staphylococcus aureus]
ATGAATAACATTTTGTTAAATGCTATCAATATAGTTATTACTACCACTTTTGTTATCTTTAATATTTTAATCACATATAA
TAAAGATTTAGATGATTTATGTTGGCTCCTGCCTGGTATTATCATTTGTGGTGTGATACTCATCGTATCCTTTACCATTG
CAATGATAACTAAAAACTGGTTAAGTGAAATATTATTTTTTATAAATATCGTACTCGTTCTCTATTACATTTATCCTATT
TTTTATAGTTTTATAGGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0D6HZ40

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VN56

References