Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-PHD
Location 4109302..4110011 Replicon chromosome
Accession NZ_AP025688
Organism Tsukamurella sp. PLM1

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag MTP03_RS21090 Protein ID WP_248489833.1
Coordinates 4109589..4110011 (+) Length 141 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag MTP03_RS21085 Protein ID WP_248489832.1
Coordinates 4109302..4109592 (+) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MTP03_RS21070 (MTP03_45090) 4105534..4106241 + 708 WP_248492320.1 glutamine amidotransferase -
MTP03_RS21075 (MTP03_45100) 4106465..4107928 + 1464 WP_248489830.1 DUF2786 domain-containing protein -
MTP03_RS21080 (MTP03_45110) 4108163..4109272 + 1110 WP_248489831.1 hypothetical protein -
MTP03_RS21085 (MTP03_45120) 4109302..4109592 + 291 WP_248489832.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
MTP03_RS21090 (MTP03_45130) 4109589..4110011 + 423 WP_248489833.1 type II toxin-antitoxin system VapC family toxin Toxin
MTP03_RS21095 (MTP03_45140) 4110147..4110464 - 318 WP_248492368.1 hypothetical protein -
MTP03_RS21100 4110461..4110742 - 282 WP_248492321.1 MGMT family protein -
MTP03_RS21105 4111185..4111478 - 294 Protein_4233 SRPBCC family protein -
MTP03_RS21110 (MTP03_45160) 4111488..4112087 - 600 WP_248489834.1 DinB family protein -
MTP03_RS21115 (MTP03_45170) 4112147..4112698 - 552 WP_248489835.1 hypothetical protein -
MTP03_RS21120 (MTP03_45180) 4112702..4113354 - 653 Protein_4236 recombination mediator RecR -
MTP03_RS21125 (MTP03_45190) 4113365..4113655 - 291 WP_248492322.1 YbaB/EbfC family nucleoid-associated protein -
MTP03_RS22975 (MTP03_45200) 4113905..4114282 + 378 WP_256465183.1 N-acetylmuramoyl-L-alanine amidase -
MTP03_RS22980 (MTP03_45210) 4114279..4114590 + 312 WP_256465184.1 N-acetylmuramoyl-L-alanine amidase -
MTP03_RS21135 (MTP03_45220) 4114595..4114972 - 378 WP_248489836.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-122)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-46)


Sequences

Toxin        


Download         Length: 141 a.a.        Molecular weight: 14894.69 Da        Isoelectric Point: 4.2336

>T40651 WP_248489833.1 NZ_AP025688:4109589-4110011 [Tsukamurella sp. PLM1]
MIYMDTSALTKLIIAEHESDALTTWVAEQAEANETLTTSDVGRIELMRAATRRDDEEIFEHAGYVANQINSASVTEEIVA
GAQSIGPLTLRTLDAIHLASAVSIRDQVSAFVSYDKRLLDAARAVGLPVVSPGAGAPDAP

Download         Length: 423 bp

>T40651 NZ_AP025688:4109589-4110011 [Tsukamurella sp. PLM1]
ATGATCTACATGGACACCTCGGCGCTGACCAAGCTCATCATCGCCGAGCATGAATCGGACGCGCTCACCACATGGGTCGC
CGAGCAGGCCGAGGCGAATGAAACGTTGACGACCAGCGACGTCGGCCGTATCGAGCTGATGCGCGCGGCGACACGCCGCG
ACGACGAGGAGATCTTCGAGCACGCCGGATACGTGGCGAACCAGATCAACAGTGCCTCCGTAACCGAGGAGATCGTTGCG
GGGGCCCAGAGCATCGGACCACTGACACTGCGCACGCTCGACGCGATCCACCTGGCGTCAGCAGTGAGCATCCGCGACCA
GGTCAGCGCGTTCGTCAGCTACGACAAGCGGCTGCTGGACGCGGCGCGAGCGGTGGGACTTCCCGTCGTCTCGCCCGGCG
CGGGCGCTCCGGACGCGCCATAG

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 11073.90 Da        Isoelectric Point: 10.2068

>AT40651 WP_248489832.1 NZ_AP025688:4109302-4109592 [Tsukamurella sp. PLM1]
MEQIGVRELRQHASKYLARVEAGEEIEVTNHGRLVARLVPVSEKERQYRNLVAAGKIKPAKHPFDLEKITAMRKARKPLQ
PGEKTLTEILMEMREE

Download         Length: 291 bp

>AT40651 NZ_AP025688:4109302-4109592 [Tsukamurella sp. PLM1]
ATGGAGCAGATCGGCGTCCGGGAACTGCGGCAGCACGCCTCGAAGTACCTCGCGCGCGTGGAGGCGGGCGAGGAGATCGA
GGTGACCAACCACGGCAGGCTCGTCGCCCGGTTGGTCCCGGTCAGCGAGAAGGAGCGCCAGTACCGGAATTTGGTCGCGG
CCGGCAAGATCAAGCCCGCCAAGCACCCGTTCGACCTCGAGAAGATCACAGCGATGCGGAAGGCTCGGAAACCCTTGCAG
CCGGGGGAGAAGACGCTGACCGAGATCCTCATGGAGATGCGGGAAGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References