Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 2139958..2140472 Replicon chromosome
Accession NZ_AP025683
Organism Staphylococcus aureus strain JP025

Toxin (Protein)


Gene name TsdT Uniprot ID A0A7U7IDH9
Locus tag SAJP025_RS10470 Protein ID WP_000581791.1
Coordinates 2139958..2140167 (-) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID A0A0D1GBN9
Locus tag SAJP025_RS10475 Protein ID WP_000138934.1
Coordinates 2140179..2140472 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SAJP025_RS10450 (2135847) 2135847..2136917 - 1071 WP_000159638.1 D-alanine--D-alanine ligase -
SAJP025_RS10455 (2137235) 2137235..2138437 + 1203 WP_001109939.1 FtsW/RodA/SpoVE family cell cycle protein -
SAJP025_RS10460 (2138598) 2138598..2139281 - 684 Protein_2023 transposase -
SAJP025_RS10465 (2139693) 2139693..2139830 - 138 WP_000828354.1 Lmo0850 family protein -
SAJP025_RS10470 (2139958) 2139958..2140167 - 210 WP_000581791.1 heavy metal-associated domain-containing protein Toxin
SAJP025_RS10475 (2140179) 2140179..2140472 - 294 WP_000138934.1 copper-sensing transcriptional repressor CsoR Antitoxin
SAJP025_RS10480 (2140638) 2140638..2142122 + 1485 WP_000571563.1 cardiolipin synthase -
SAJP025_RS10485 (2142150) 2142150..2142797 + 648 WP_001187612.1 HD domain-containing protein -
SAJP025_RS10490 (2143054) 2143054..2143353 + 300 WP_001793952.1 hypothetical protein -
SAJP025_RS10495 (2143510) 2143510..2144382 - 873 WP_000725802.1 membrane protein insertase YidC -
SAJP025_RS10500 (2144468) 2144468..2145109 - 642 WP_000483150.1 thiamine phosphate synthase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(23-66)

Antitoxin

Metal-sensitive transcriptional repressor

(3-95)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7826.83 Da        Isoelectric Point: 4.1008

>T40640 WP_000581791.1 NZ_AP025683:c2140167-2139958 [Staphylococcus aureus]
MIHQNTIYTAGIETEEQVSQLTERISNMIGVHQVIINIIDGQVTVAYETPANLNSIEKEIYDEGYKIVF

Download         Length: 210 bp

>T40640 NZ_AP025683:c2140167-2139958 [Staphylococcus aureus]
ATGATACATCAAAATACGATTTACACAGCGGGAATTGAAACAGAAGAACAAGTAAGTCAATTGACAGAACGCATTTCAAA
TATGATAGGTGTTCATCAAGTGATTATTAATATAATAGACGGTCAGGTAACTGTAGCGTATGAGACACCAGCAAATTTGA
ATAGTATTGAAAAAGAAATCTATGATGAAGGATACAAAATTGTATTTTAG

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11185.77 Da        Isoelectric Point: 6.2243

>AT40640 WP_000138934.1 NZ_AP025683:c2140472-2140179 [Staphylococcus aureus]
MTEQDNAHHSEQIKTNLKSRLNRIEGQVRAINRMIEEDVYCDDVLTQIRATRSALNSVATKLLEQHMKSCIMNKVNQGAQ
EEAMEELLVTFQKLIKD

Download         Length: 294 bp

>AT40640 NZ_AP025683:c2140472-2140179 [Staphylococcus aureus]
ATGACTGAACAAGATAATGCACATCATTCTGAACAAATAAAAACGAATCTTAAATCACGTTTAAATCGAATTGAAGGACA
AGTGAGAGCGATTAATCGCATGATTGAAGAAGATGTCTATTGTGATGATGTCCTTACGCAAATAAGAGCGACACGTTCGG
CGTTAAACAGTGTTGCGACAAAGTTATTAGAACAACATATGAAAAGTTGTATTATGAATAAAGTTAATCAAGGTGCTCAG
GAAGAGGCAATGGAAGAGTTATTAGTGACTTTTCAAAAATTGATTAAAGACTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U7IDH9

Antitoxin

Source ID Structure
AlphaFold DB A0A0D1GBN9

References