Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 2119222..2119751 Replicon chromosome
Accession NZ_AP025683
Organism Staphylococcus aureus strain JP025

Toxin (Protein)


Gene name mazF Uniprot ID Q6GF05
Locus tag SAJP025_RS10375 Protein ID WP_000621176.1
Coordinates 2119222..2119584 (-) Length 121 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID T1YCG8
Locus tag SAJP025_RS10380 Protein ID WP_000948331.1
Coordinates 2119581..2119751 (-) Length 57 a.a.

Genomic Context


SAJP025_RS10355SAJP025_RS10360SAJP025_RS10365SAJP025_RS10370SAJP025_RS10375SAJP025_RS10380SAJP025_RS10385SAJP025_RS10390SAJP025_RS10395SAJP025_RS10400SAJP025_RS10405SAJP025_RS10410
Location: 2116200..2116970 (771 bp)
Type: Others
Protein ID: WP_001041107.1
Location: 2116945..2117424 (480 bp)
Type: Others
Protein ID: WP_001190825.1
Location: 2117426..2117752 (327 bp)
Type: Others
Protein ID: WP_001052491.1
Location: 2117871..2118872 (1002 bp)
Type: Others
Protein ID: WP_000390829.1
Location: 2119222..2119584 (363 bp)
Type: Toxin
Protein ID: WP_000621176.1
Location: 2119581..2119751 (171 bp)
Type: Antitoxin
Protein ID: WP_000948331.1
Location: 2119836..2120984 (1149 bp)
Type: Others
Protein ID: WP_001281140.1
Location: 2121050..2121409 (360 bp)
Type: Others
Protein ID: WP_000581197.1
Location: 2121413..2121904 (492 bp)
Type: Others
Protein ID: WP_001286801.1
Location: 2121897..2123474 (1578 bp)
Type: Others
Protein ID: WP_001294646.1
Location: 2123467..2123946 (480 bp)
Type: Others
Protein ID: WP_001287082.1
Location: 2124155..2124715 (561 bp)
Type: Others
Protein ID: WP_001092414.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
SAJP025_RS10355 (2116200)2116200..2116970-771WP_001041107.1RNA polymerase sigma factor SigB-
SAJP025_RS10360 (2116945)2116945..2117424-480WP_001190825.1anti-sigma B factor RsbW-
SAJP025_RS10365 (2117426)2117426..2117752-327WP_001052491.1anti-sigma factor antagonist-
SAJP025_RS10370 (2117871)2117871..2118872-1002WP_000390829.1PP2C family protein-serine/threonine phosphatase-
SAJP025_RS10375 (2119222)2119222..2119584-363WP_000621176.1type II toxin-antitoxin system PemK/MazF family toxinToxin
SAJP025_RS10380 (2119581)2119581..2119751-171WP_000948331.1type II toxin-antitoxin system antitoxin MazEAntitoxin
SAJP025_RS10385 (2119836)2119836..2120984-1149WP_001281140.1alanine racemase-
SAJP025_RS10390 (2121050)2121050..2121409-360WP_000581197.1holo-ACP synthase-
SAJP025_RS10395 (2121413)2121413..2121904-492WP_001286801.1PH domain-containing protein-
SAJP025_RS10400 (2121897)2121897..2123474-1578WP_001294646.1PH domain-containing protein-
SAJP025_RS10405 (2123467)2123467..2123946-480WP_001287082.1hypothetical protein-
SAJP025_RS10410 (2124155)2124155..2124715-561WP_001092414.1K(+)-transporting ATPase subunit C-

Associated MGEs


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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(3-110)

Antitoxin


No domain identified.



Sequences


Toxin        


Download         Length: 121 a.a.        Molecular weight: 13469.74 Da        Isoelectric Point: 10.1654

>T40639 WP_000621176.1 NZ_AP025683:c2119584-2119222 [Staphylococcus aureus]
MIRRGDVYLADLSPVQGSEQGGVRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKKKYKLDKDSVILLEQIR
TLDKKRLKEKLTYLSDDKMKEVDNALMISLGLNAVVHQKN

Download         Length: 363 bp

>T40639 NZ_AP025683:c2119584-2119222 [Staphylococcus aureus]
ATGATTAGACGAGGAGATGTTTATTTAGCAGATTTATCACCAGTACAGGGATCTGAACAAGGGGGAGTCAGACCTGTAGT
CATAATTCAAAATGATACTGGTAATAAATATAGTCCTACAGTTATTGTTGCGGCAATAACTGGTAGGATTAACAAAGCGA
AAATACCGACACATGTAGAGATTGAAAAGAAAAAGTATAAATTGGATAAAGACTCAGTTATATTATTAGAGCAAATTCGT
ACACTTGATAAAAAACGATTGAAAGAAAAACTGACATACTTATCCGATGATAAAATGAAAGAAGTAGATAATGCACTAAT
GATTAGTTTAGGGCTGAATGCAGTAGTTCATCAGAAAAATTAG

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6251.78 Da        Isoelectric Point: 3.8305

>AT40639 WP_000948331.1 NZ_AP025683:c2119751-2119581 [Staphylococcus aureus]
MLSFSQNRSHSLEQSLKEGYSQMADLNLSLANEAFPIECEACDCNETYLSSNSTNE

Download         Length: 171 bp

>AT40639 NZ_AP025683:c2119751-2119581 [Staphylococcus aureus]
ATGTTATCTTTTAGTCAAAATAGAAGTCATAGCTTAGAACAATCTTTAAAAGAAGGATATTCACAAATGGCTGATTTAAA
TCTCTCCCTAGCGAACGAAGCTTTTCCGATAGAGTGTGAAGCATGCGATTGCAACGAAACATATTTATCTTCTAATTCAA
CGAATGAATGA

Similar Proteins


Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures


Toxin

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Source
ID
Structure
AlphaFold DBA0A168PYX0


Antitoxin

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Source
ID
Structure
AlphaFold DBA0A0E0VRZ1

References