Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | mazEF/MazF(toxin) |
Location | 2119222..2119751 | Replicon | chromosome |
Accession | NZ_AP025683 | ||
Organism | Staphylococcus aureus strain JP025 |
Toxin (Protein)
Gene name | mazF | Uniprot ID | Q6GF05 |
Locus tag | SAJP025_RS10375 | Protein ID | WP_000621176.1 |
Coordinates | 2119222..2119584 (-) | Length | 121 a.a. |
Antitoxin (Protein)
Gene name | mazE | Uniprot ID | T1YCG8 |
Locus tag | SAJP025_RS10380 | Protein ID | WP_000948331.1 |
Coordinates | 2119581..2119751 (-) | Length | 57 a.a. |
Genomic Context
Location: 2116200..2116970 (771 bp)
Type: Others
Protein ID: WP_001041107.1
Type: Others
Protein ID: WP_001041107.1
Location: 2116945..2117424 (480 bp)
Type: Others
Protein ID: WP_001190825.1
Type: Others
Protein ID: WP_001190825.1
Location: 2117426..2117752 (327 bp)
Type: Others
Protein ID: WP_001052491.1
Type: Others
Protein ID: WP_001052491.1
Location: 2117871..2118872 (1002 bp)
Type: Others
Protein ID: WP_000390829.1
Type: Others
Protein ID: WP_000390829.1
Location: 2119222..2119584 (363 bp)
Type: Toxin
Protein ID: WP_000621176.1
Type: Toxin
Protein ID: WP_000621176.1
Location: 2119581..2119751 (171 bp)
Type: Antitoxin
Protein ID: WP_000948331.1
Type: Antitoxin
Protein ID: WP_000948331.1
Location: 2119836..2120984 (1149 bp)
Type: Others
Protein ID: WP_001281140.1
Type: Others
Protein ID: WP_001281140.1
Location: 2121050..2121409 (360 bp)
Type: Others
Protein ID: WP_000581197.1
Type: Others
Protein ID: WP_000581197.1
Location: 2121413..2121904 (492 bp)
Type: Others
Protein ID: WP_001286801.1
Type: Others
Protein ID: WP_001286801.1
Location: 2121897..2123474 (1578 bp)
Type: Others
Protein ID: WP_001294646.1
Type: Others
Protein ID: WP_001294646.1
Location: 2123467..2123946 (480 bp)
Type: Others
Protein ID: WP_001287082.1
Type: Others
Protein ID: WP_001287082.1
Location: 2124155..2124715 (561 bp)
Type: Others
Protein ID: WP_001092414.1
Type: Others
Protein ID: WP_001092414.1
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Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
SAJP025_RS10355 (2116200) | 2116200..2116970 | - | 771 | WP_001041107.1 | RNA polymerase sigma factor SigB | - |
SAJP025_RS10360 (2116945) | 2116945..2117424 | - | 480 | WP_001190825.1 | anti-sigma B factor RsbW | - |
SAJP025_RS10365 (2117426) | 2117426..2117752 | - | 327 | WP_001052491.1 | anti-sigma factor antagonist | - |
SAJP025_RS10370 (2117871) | 2117871..2118872 | - | 1002 | WP_000390829.1 | PP2C family protein-serine/threonine phosphatase | - |
SAJP025_RS10375 (2119222) | 2119222..2119584 | - | 363 | WP_000621176.1 | type II toxin-antitoxin system PemK/MazF family toxin | Toxin |
SAJP025_RS10380 (2119581) | 2119581..2119751 | - | 171 | WP_000948331.1 | type II toxin-antitoxin system antitoxin MazE | Antitoxin |
SAJP025_RS10385 (2119836) | 2119836..2120984 | - | 1149 | WP_001281140.1 | alanine racemase | - |
SAJP025_RS10390 (2121050) | 2121050..2121409 | - | 360 | WP_000581197.1 | holo-ACP synthase | - |
SAJP025_RS10395 (2121413) | 2121413..2121904 | - | 492 | WP_001286801.1 | PH domain-containing protein | - |
SAJP025_RS10400 (2121897) | 2121897..2123474 | - | 1578 | WP_001294646.1 | PH domain-containing protein | - |
SAJP025_RS10405 (2123467) | 2123467..2123946 | - | 480 | WP_001287082.1 | hypothetical protein | - |
SAJP025_RS10410 (2124155) | 2124155..2124715 | - | 561 | WP_001092414.1 | K(+)-transporting ATPase subunit C | - |
Associated MGEs
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MGE detail | Similar MGEs | Relative position | MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
No matching records found |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 121 a.a. Molecular weight: 13469.74 Da Isoelectric Point: 10.1654
>T40639 WP_000621176.1 NZ_AP025683:c2119584-2119222 [Staphylococcus aureus]
MIRRGDVYLADLSPVQGSEQGGVRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKKKYKLDKDSVILLEQIR
TLDKKRLKEKLTYLSDDKMKEVDNALMISLGLNAVVHQKN
MIRRGDVYLADLSPVQGSEQGGVRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKKKYKLDKDSVILLEQIR
TLDKKRLKEKLTYLSDDKMKEVDNALMISLGLNAVVHQKN
Download Length: 363 bp
>T40639 NZ_AP025683:c2119584-2119222 [Staphylococcus aureus]
ATGATTAGACGAGGAGATGTTTATTTAGCAGATTTATCACCAGTACAGGGATCTGAACAAGGGGGAGTCAGACCTGTAGT
CATAATTCAAAATGATACTGGTAATAAATATAGTCCTACAGTTATTGTTGCGGCAATAACTGGTAGGATTAACAAAGCGA
AAATACCGACACATGTAGAGATTGAAAAGAAAAAGTATAAATTGGATAAAGACTCAGTTATATTATTAGAGCAAATTCGT
ACACTTGATAAAAAACGATTGAAAGAAAAACTGACATACTTATCCGATGATAAAATGAAAGAAGTAGATAATGCACTAAT
GATTAGTTTAGGGCTGAATGCAGTAGTTCATCAGAAAAATTAG
ATGATTAGACGAGGAGATGTTTATTTAGCAGATTTATCACCAGTACAGGGATCTGAACAAGGGGGAGTCAGACCTGTAGT
CATAATTCAAAATGATACTGGTAATAAATATAGTCCTACAGTTATTGTTGCGGCAATAACTGGTAGGATTAACAAAGCGA
AAATACCGACACATGTAGAGATTGAAAAGAAAAAGTATAAATTGGATAAAGACTCAGTTATATTATTAGAGCAAATTCGT
ACACTTGATAAAAAACGATTGAAAGAAAAACTGACATACTTATCCGATGATAAAATGAAAGAAGTAGATAATGCACTAAT
GATTAGTTTAGGGCTGAATGCAGTAGTTCATCAGAAAAATTAG
Antitoxin
Download Length: 57 a.a. Molecular weight: 6251.78 Da Isoelectric Point: 3.8305
>AT40639 WP_000948331.1 NZ_AP025683:c2119751-2119581 [Staphylococcus aureus]
MLSFSQNRSHSLEQSLKEGYSQMADLNLSLANEAFPIECEACDCNETYLSSNSTNE
MLSFSQNRSHSLEQSLKEGYSQMADLNLSLANEAFPIECEACDCNETYLSSNSTNE
Download Length: 171 bp
>AT40639 NZ_AP025683:c2119751-2119581 [Staphylococcus aureus]
ATGTTATCTTTTAGTCAAAATAGAAGTCATAGCTTAGAACAATCTTTAAAAGAAGGATATTCACAAATGGCTGATTTAAA
TCTCTCCCTAGCGAACGAAGCTTTTCCGATAGAGTGTGAAGCATGCGATTGCAACGAAACATATTTATCTTCTAATTCAA
CGAATGAATGA
ATGTTATCTTTTAGTCAAAATAGAAGTCATAGCTTAGAACAATCTTTAAAAGAAGGATATTCACAAATGGCTGATTTAAA
TCTCTCCCTAGCGAACGAAGCTTTTCCGATAGAGTGTGAAGCATGCGATTGCAACGAAACATATTTATCTTCTAATTCAA
CGAATGAATGA
Structures
Toxin
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Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A168PYX0 |
Antitoxin
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Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A0E0VRZ1 |