40639

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 2119222..2119751 Replicon chromosome
Accession NZ_AP025683
Organism Staphylococcus aureus strain JP025

Toxin (Protein)


Gene name mazF Uniprot ID Q6GF05
Locus tag SAJP025_RS10375 Protein ID WP_000621176.1
Coordinates 2119222..2119584 (-) Length 121 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID T1YCG8
Locus tag SAJP025_RS10380 Protein ID WP_000948331.1
Coordinates 2119581..2119751 (-) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SAJP025_RS10355 (2116200) 2116200..2116970 - 771 WP_001041107.1 RNA polymerase sigma factor SigB -
SAJP025_RS10360 (2116945) 2116945..2117424 - 480 WP_001190825.1 anti-sigma B factor RsbW -
SAJP025_RS10365 (2117426) 2117426..2117752 - 327 WP_001052491.1 anti-sigma factor antagonist -
SAJP025_RS10370 (2117871) 2117871..2118872 - 1002 WP_000390829.1 PP2C family protein-serine/threonine phosphatase -
SAJP025_RS10375 (2119222) 2119222..2119584 - 363 WP_000621176.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
SAJP025_RS10380 (2119581) 2119581..2119751 - 171 WP_000948331.1 type II toxin-antitoxin system antitoxin MazE Antitoxin
SAJP025_RS10385 (2119836) 2119836..2120984 - 1149 WP_001281140.1 alanine racemase -
SAJP025_RS10390 (2121050) 2121050..2121409 - 360 WP_000581197.1 holo-ACP synthase -
SAJP025_RS10395 (2121413) 2121413..2121904 - 492 WP_001286801.1 PH domain-containing protein -
SAJP025_RS10400 (2121897) 2121897..2123474 - 1578 WP_001294646.1 PH domain-containing protein -
SAJP025_RS10405 (2123467) 2123467..2123946 - 480 WP_001287082.1 hypothetical protein -
SAJP025_RS10410 (2124155) 2124155..2124715 - 561 WP_001092414.1 K(+)-transporting ATPase subunit C -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(3-110)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 121 a.a.        Molecular weight: 13469.74 Da        Isoelectric Point: 10.1654

>T40639 WP_000621176.1 NZ_AP025683:c2119584-2119222 [Staphylococcus aureus]
MIRRGDVYLADLSPVQGSEQGGVRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKKKYKLDKDSVILLEQIR
TLDKKRLKEKLTYLSDDKMKEVDNALMISLGLNAVVHQKN

Download         Length: 363 bp

>T40639 NZ_AP025683:c2119584-2119222 [Staphylococcus aureus]
ATGATTAGACGAGGAGATGTTTATTTAGCAGATTTATCACCAGTACAGGGATCTGAACAAGGGGGAGTCAGACCTGTAGT
CATAATTCAAAATGATACTGGTAATAAATATAGTCCTACAGTTATTGTTGCGGCAATAACTGGTAGGATTAACAAAGCGA
AAATACCGACACATGTAGAGATTGAAAAGAAAAAGTATAAATTGGATAAAGACTCAGTTATATTATTAGAGCAAATTCGT
ACACTTGATAAAAAACGATTGAAAGAAAAACTGACATACTTATCCGATGATAAAATGAAAGAAGTAGATAATGCACTAAT
GATTAGTTTAGGGCTGAATGCAGTAGTTCATCAGAAAAATTAG

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6251.78 Da        Isoelectric Point: 3.8305

>AT40639 WP_000948331.1 NZ_AP025683:c2119751-2119581 [Staphylococcus aureus]
MLSFSQNRSHSLEQSLKEGYSQMADLNLSLANEAFPIECEACDCNETYLSSNSTNE

Download         Length: 171 bp

>AT40639 NZ_AP025683:c2119751-2119581 [Staphylococcus aureus]
ATGTTATCTTTTAGTCAAAATAGAAGTCATAGCTTAGAACAATCTTTAAAAGAAGGATATTCACAAATGGCTGATTTAAA
TCTCTCCCTAGCGAACGAAGCTTTTCCGATAGAGTGTGAAGCATGCGATTGCAACGAAACATATTTATCTTCTAATTCAA
CGAATGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A168PYX0

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VRZ1

References