Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /HTH_19(antitoxin)
Location 1563973..1564761 Replicon chromosome
Accession NZ_AP025683
Organism Staphylococcus aureus strain JP025

Toxin (Protein)


Gene name - Uniprot ID A0A2I7Y5B3
Locus tag SAJP025_RS07455 Protein ID WP_000525004.1
Coordinates 1564300..1564761 (+) Length 154 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID A0A0E7YIA0
Locus tag SAJP025_RS07450 Protein ID WP_000333630.1
Coordinates 1563973..1564287 (+) Length 105 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SAJP025_RS07390 (1559115) 1559115..1560281 - 1167 WP_000762532.1 DUF2800 domain-containing protein -
SAJP025_RS07395 (1560278) 1560278..1560640 - 363 WP_000279449.1 hypothetical protein -
SAJP025_RS07400 (1560655) 1560655..1560978 - 324 WP_000175000.1 hypothetical protein -
SAJP025_RS07405 (1561057) 1561057..1561218 - 162 WP_001285963.1 DUF1270 family protein -
SAJP025_RS07410 (1561231) 1561231..1561494 - 264 WP_001124190.1 helix-turn-helix domain-containing protein -
SAJP025_RS07415 (1561519) 1561519..1561734 - 216 WP_001036302.1 hypothetical protein -
SAJP025_RS07420 (1561789) 1561789..1562154 + 366 WP_001128433.1 hypothetical protein -
SAJP025_RS07425 (1562123) 1562123..1562368 - 246 WP_001025401.1 DUF2829 domain-containing protein -
SAJP025_RS07430 (1562424) 1562424..1562633 + 210 WP_000642492.1 hypothetical protein -
SAJP025_RS07435 (1562623) 1562623..1562766 - 144 WP_000939498.1 hypothetical protein -
SAJP025_RS07440 (1562795) 1562795..1563571 - 777 WP_001148544.1 Rha family transcriptional regulator -
SAJP025_RS07445 (1563585) 1563585..1563821 - 237 WP_001121027.1 helix-turn-helix transcriptional regulator -
SAJP025_RS07450 (1563973) 1563973..1564287 + 315 WP_000333630.1 helix-turn-helix transcriptional regulator Antitoxin
SAJP025_RS07455 (1564300) 1564300..1564761 + 462 WP_000525004.1 hypothetical protein Toxin
SAJP025_RS07460 (1564779) 1564779..1565363 + 585 WP_000825948.1 hypothetical protein -
SAJP025_RS07465 (1565593) 1565593..1565739 + 147 WP_001013104.1 hypothetical protein -
SAJP025_RS07470 (1565736) 1565736..1566350 - 615 WP_000191459.1 hypothetical protein -
SAJP025_RS07475 (1566476) 1566476..1567681 + 1206 WP_000264747.1 site-specific integrase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - lukF-PV / lukS-PV 1521593..1580456 58863


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(4-62)


Sequences

Toxin        


Download         Length: 154 a.a.        Molecular weight: 18074.46 Da        Isoelectric Point: 4.6915

>T40632 WP_000525004.1 NZ_AP025683:1564300-1564761 [Staphylococcus aureus]
MGLYEETLIQHDYIEIREADVLPDNLDGVWLGDLILIKRGLSDREKAGILFEELAHNKLTYGDIADYSKFNNRKFENYAR
RHGFISAVPLREIVEAYNYGVRNLYELSEYLQLSEEYILEAIEQYKKIYGIGTHYGEYSITFEPLRVFKYKEI

Download         Length: 462 bp

>T40632 NZ_AP025683:1564300-1564761 [Staphylococcus aureus]
ATGGGATTATATGAAGAAACTTTAATACAACATGATTATATTGAAATAAGAGAGGCTGATGTGCTTCCAGATAATTTGGA
TGGGGTATGGTTAGGAGATTTAATTTTAATAAAGCGTGGCTTATCAGATAGAGAAAAGGCAGGAATTCTCTTTGAAGAAT
TAGCACATAATAAACTTACATACGGTGATATAGCCGATTACTCGAAATTCAACAATCGCAAGTTCGAAAATTACGCAAGG
CGACACGGCTTTATCTCAGCAGTCCCGTTACGCGAAATTGTGGAAGCTTACAATTATGGTGTACGTAACTTGTATGAGTT
GTCTGAGTATCTGCAATTGAGTGAAGAATACATATTAGAAGCAATAGAACAATATAAAAAGATATATGGTATTGGGACTC
ACTACGGCGAATACTCAATTACATTTGAGCCATTGAGAGTTTTTAAATATAAAGAAATATAA

Antitoxin


Download         Length: 105 a.a.        Molecular weight: 12063.56 Da        Isoelectric Point: 6.4736

>AT40632 WP_000333630.1 NZ_AP025683:1563973-1564287 [Staphylococcus aureus]
MCFSKRMKQSREKQGMTLAELGRKIGKTEATVQRYESGNIKNLKNDTIESIATALNVNPAYLMGWVEENDDEVQHRAAHL
EGELTDDEWQRVLDYADYIRSKRK

Download         Length: 315 bp

>AT40632 NZ_AP025683:1563973-1564287 [Staphylococcus aureus]
ATGTGCTTTTCAAAAAGAATGAAACAATCAAGAGAAAAACAAGGTATGACTTTGGCCGAACTAGGAAGAAAAATTGGTAA
AACTGAAGCTACTGTACAGCGTTATGAAAGCGGAAATATCAAAAATTTAAAAAACGATACTATAGAAAGTATAGCTACTG
CATTAAATGTTAATCCTGCATATTTAATGGGGTGGGTTGAAGAAAACGATGATGAAGTACAACATCGTGCAGCTCACCTT
GAAGGAGAATTGACAGATGATGAATGGCAAAGAGTTTTAGATTATGCAGATTATATAAGAAGCAAACGTAAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2I7Y5B3

Antitoxin

Source ID Structure
AlphaFold DB A0A0E7YIA0

References