Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 828051..828528 Replicon chromosome
Accession NZ_AP025683
Organism Staphylococcus aureus strain JP025

Toxin (Protein)


Gene name TsaT Uniprot ID T1Y7S2
Locus tag SAJP025_RS03865 Protein ID WP_000052076.1
Coordinates 828051..828239 (-) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID T1Y6P8
Locus tag SAJP025_RS03870 Protein ID WP_001059690.1
Coordinates 828268..828528 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SAJP025_RS03835 (824004) 824004..824561 + 558 WP_000824491.1 hypothetical protein -
SAJP025_RS03840 (824902) 824902..825588 + 687 WP_001574556.1 thermonuclease family protein -
SAJP025_RS03845 (825945) 825945..826145 + 201 WP_001059082.1 cold-shock protein -
SAJP025_RS03850 (826642) 826642..826860 - 219 WP_000005879.1 hypothetical protein -
SAJP025_RS03855 (826922) 826922..827206 - 285 WP_001004401.1 hypothetical protein -
SAJP025_RS03860 (827294) 827294..827863 - 570 WP_001106663.1 lipoprotein N-acylation protein LnsA -
SAJP025_RS03865 (828051) 828051..828239 - 189 WP_000052076.1 hypothetical protein Toxin
SAJP025_RS03870 (828268) 828268..828528 - 261 WP_001059690.1 hypothetical protein Antitoxin
SAJP025_RS03875 (828869) 828869..829072 + 204 WP_000145163.1 sterile alpha motif-like domain-containing protein -
SAJP025_RS03880 (829069) 829069..829305 - 237 WP_000368687.1 hypothetical protein -
SAJP025_RS03885 (829530) 829530..830111 + 582 WP_001140696.1 histidine phosphatase family protein -
SAJP025_RS03890 (830184) 830184..830801 - 618 WP_000255548.1 LysE/ArgO family amino acid transporter -
SAJP025_RS03895 (830958) 830958..831452 - 495 WP_000569884.1 GNAT family N-acetyltransferase -
SAJP025_RS03900 (831851) 831851..832273 - 423 WP_000974455.1 organic hydroperoxide resistance protein -
SAJP025_RS03905 (832421) 832421..833137 + 717 WP_000150025.1 type I 3-dehydroquinate dehydratase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 822648..856177 33529


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin CcdB

(2-39)

Antitoxin

Post-segregation antitoxin CcdA

(8-77)


Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7142.82 Da        Isoelectric Point: 9.9971

>T40628 WP_000052076.1 NZ_AP025683:c828239-828051 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Download         Length: 189 bp

>T40628 NZ_AP025683:c828239-828051 [Staphylococcus aureus]
ATGTCTTTACATTTTGCAATTCTGTTTTGGCTAGCATTAATTTTCTTAGTTGCCGCTACGTTTATACTCGTATTAATGAA
AAAAACTGGCAAAGAATCTAAAAAAGAGTCCTATTTAAGTTTCACTGTCATTCTCTATATTTTCGGATTCGCTATTTTAA
TATACACATTTATATTTGGTGTGCTATAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9940.09 Da        Isoelectric Point: 4.0624

>AT40628 WP_001059690.1 NZ_AP025683:c828528-828268 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Download         Length: 261 bp

>AT40628 NZ_AP025683:c828528-828268 [Staphylococcus aureus]
ATGAATAACATTTTGTTAAATGCTATCAATATAGTTATTACTACCACTTTTGTTATCTTTAATATTTTAATCACATATAA
TAAAGATTTAGATGATTTATGTTGGCTCCTGCCTGGTATTATCATTTGTGGTGTGATACTCATAGTATCCTTTACCATTG
CAATGATAACTAAAAACTGGTTAAGTGAAATATTATTTTTTATAAATATCGTACTCGTTCTCTATTACATTTATCCTATT
TTTTATAGTTTTATAGGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0VP18

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VN56

References