Detailed information of TA system
Overview
TA module
| Type | IV | Classification (family/domain) | yeeUV (cbtA-cbeA)/CbtA-CbeA |
| Location | 4427990..4428825 | Replicon | chromosome |
| Accession | NZ_AP025682 | ||
| Organism | Escherichia coli strain Rb-50 | ||
Toxin (Protein)
| Gene name | yeeV | Uniprot ID | - |
| Locus tag | EcoliRb_RS21280 | Protein ID | WP_137493869.1 |
| Coordinates | 4428448..4428825 (+) | Length | 126 a.a. |
Antitoxin (Protein)
| Gene name | yeeU | Uniprot ID | A0A7D7KDU2 |
| Locus tag | EcoliRb_RS21275 | Protein ID | WP_053289218.1 |
| Coordinates | 4427990..4428358 (+) | Length | 123 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| EcoliRb_RS21240 (4423906) | 4423906..4424586 | + | 681 | WP_001282919.1 | WYL domain-containing protein | - |
| EcoliRb_RS21245 (4424734) | 4424734..4425411 | + | 678 | WP_001097301.1 | hypothetical protein | - |
| EcoliRb_RS21250 (4425417) | 4425417..4425650 | + | 234 | WP_001278287.1 | DUF905 family protein | - |
| EcoliRb_RS21255 (4425740) | 4425740..4426558 | + | 819 | WP_137493870.1 | DUF932 domain-containing protein | - |
| EcoliRb_RS21260 (4426650) | 4426650..4427135 | + | 486 | WP_000206664.1 | antirestriction protein | - |
| EcoliRb_RS21265 (4427150) | 4427150..4427626 | + | 477 | WP_001186171.1 | RadC family protein | - |
| EcoliRb_RS21270 (4427689) | 4427689..4427910 | + | 222 | WP_000692300.1 | DUF987 domain-containing protein | - |
| EcoliRb_RS21275 (4427990) | 4427990..4428358 | + | 369 | WP_053289218.1 | type IV toxin-antitoxin system YeeU family antitoxin | Antitoxin |
| EcoliRb_RS21280 (4428448) | 4428448..4428825 | + | 378 | WP_137493869.1 | type IV toxin-antitoxin system cytoskeleton-binding toxin CbtA | Toxin |
| EcoliRb_RS21285 (4428822) | 4428822..4429310 | + | 489 | Protein_4174 | DUF5983 family protein | - |
| EcoliRb_RS21290 (4429327) | 4429327..4429524 | + | 198 | WP_000839265.1 | DUF957 domain-containing protein | - |
| EcoliRb_RS21295 (4429609) | 4429609..4430451 | + | 843 | WP_137493868.1 | DUF4942 domain-containing protein | - |
| EcoliRb_RS21300 (4431200) | 4431200..4432738 | + | 1539 | WP_001187191.1 | lysine decarboxylation/transport transcriptional activator CadC | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Genomic island | - | afaE-VIII / afaD-VIII / afaC-VIII / afaB-VIII / afaA-VIII / afaF-VII | 4389219..4440551 | 51332 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 126 a.a. Molecular weight: 13960.97 Da Isoelectric Point: 8.5163
>T40625 WP_137493869.1 NZ_AP025682:4428448-4428825 [Escherichia coli]
MKTLPVLPGQAASSRPSPVEIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIETGISLCDAVNFLVEKYTLVRTDQPGF
SACTRSQLINSIDILRARRATGLMARDNYRTVNNITLGKHPGAKQ
MKTLPVLPGQAASSRPSPVEIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIETGISLCDAVNFLVEKYTLVRTDQPGF
SACTRSQLINSIDILRARRATGLMARDNYRTVNNITLGKHPGAKQ
Download Length: 378 bp
>T40625 NZ_AP025682:4428448-4428825 [Escherichia coli]
ATGAAAACATTACCTGTATTACCCGGGCAGGCGGCCAGTTCACGCCCGTCTCCGGTTGAAATCTGGCAGACACTGCTCAC
CCGACTGCTGGACCAGCATTACGGCCTTACGCTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AGACAGGCATTTCACTGTGCGATGCGGTGAACTTTCTCGTTGAAAAATACACACTGGTACGTACCGACCAGCCAGGATTC
AGCGCCTGTACCCGTTCTCAGTTAATAAACAGTATTGATATCCTCCGGGCCCGCCGGGCAACCGGCCTGATGGCCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGTAAACATCCGGGGGCGAAACAATGA
ATGAAAACATTACCTGTATTACCCGGGCAGGCGGCCAGTTCACGCCCGTCTCCGGTTGAAATCTGGCAGACACTGCTCAC
CCGACTGCTGGACCAGCATTACGGCCTTACGCTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AGACAGGCATTTCACTGTGCGATGCGGTGAACTTTCTCGTTGAAAAATACACACTGGTACGTACCGACCAGCCAGGATTC
AGCGCCTGTACCCGTTCTCAGTTAATAAACAGTATTGATATCCTCCGGGCCCGCCGGGCAACCGGCCTGATGGCCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGTAAACATCCGGGGGCGAAACAATGA
Antitoxin
Download Length: 123 a.a. Molecular weight: 13715.44 Da Isoelectric Point: 6.2058
>AT40625 WP_053289218.1 NZ_AP025682:4427990-4428358 [Escherichia coli]
VSDTFSGTTHPDDNHDRPWWGLPCTVTPCFGARLVQEGNRLHYLADRADIRGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCEADTLGSCGYVYMAVYPTPETKK
VSDTFSGTTHPDDNHDRPWWGLPCTVTPCFGARLVQEGNRLHYLADRADIRGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCEADTLGSCGYVYMAVYPTPETKK
Download Length: 369 bp
>AT40625 NZ_AP025682:4427990-4428358 [Escherichia coli]
GTGTCAGACACATTCTCCGGGACAACGCATCCCGATGACAATCACGACCGCCCCTGGTGGGGGCTGCCCTGTACCGTGAC
ACCTTGTTTTGGCGCCCGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCCGACCGCGCCGATATCAGAGGCCGGT
TCAGCGACGCGGATGCGTACCATCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAGCTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACGCTGTATGCAAAAGGGCTGACCTGCGAAGCCGACACCCTCGGCAGTTG
TGGCTACGTTTATATGGCTGTTTATCCGACGCCCGAAACGAAAAAGTAA
GTGTCAGACACATTCTCCGGGACAACGCATCCCGATGACAATCACGACCGCCCCTGGTGGGGGCTGCCCTGTACCGTGAC
ACCTTGTTTTGGCGCCCGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCCGACCGCGCCGATATCAGAGGCCGGT
TCAGCGACGCGGATGCGTACCATCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAGCTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACGCTGTATGCAAAAGGGCTGACCTGCGAAGCCGACACCCTCGGCAGTTG
TGGCTACGTTTATATGGCTGTTTATCCGACGCCCGAAACGAAAAAGTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|