Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) ccdAB/CcdA(antitoxin)
Location 3989486..3990036 Replicon chromosome
Accession NZ_AP025682
Organism Escherichia coli strain Rb-50

Toxin (Protein)


Gene name ccdB Uniprot ID S1PDG4
Locus tag EcoliRb_RS19270 Protein ID WP_001160966.1
Coordinates 3989486..3989800 (-) Length 105 a.a.

Antitoxin (Protein)


Gene name ccdA Uniprot ID V0VEX8
Locus tag EcoliRb_RS19275 Protein ID WP_000125566.1
Coordinates 3989803..3990036 (-) Length 78 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EcoliRb_RS19245 (3985161) 3985161..3986447 + 1287 WP_000800457.1 peptidylprolyl isomerase SurA -
EcoliRb_RS19250 (3986447) 3986447..3987436 + 990 WP_000241226.1 4-hydroxythreonine-4-phosphate dehydrogenase PdxA -
EcoliRb_RS19255 (3987433) 3987433..3988254 + 822 WP_137500865.1 16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))- dimethyltransferase RsmA -
EcoliRb_RS19260 (3988257) 3988257..3988634 + 378 WP_000610901.1 Co2+/Mg2+ efflux protein ApaG -
EcoliRb_RS19265 (3988641) 3988641..3989489 + 849 WP_000257181.1 bis(5'-nucleosyl)-tetraphosphatase (symmetrical) ApaH -
EcoliRb_RS19270 (3989486) 3989486..3989800 - 315 WP_001160966.1 CcdB family protein Toxin
EcoliRb_RS19275 (3989803) 3989803..3990036 - 234 WP_000125566.1 type II toxin-antitoxin system CcdA family antitoxin Antitoxin
EcoliRb_RS19280 (3990122) 3990122..3990601 - 480 WP_000624375.1 type 3 dihydrofolate reductase -
EcoliRb_RS19285 (3990793) 3990793..3992655 - 1863 WP_000377124.1 glutathione-regulated potassium-efflux system protein KefC -
EcoliRb_RS19290 (3992648) 3992648..3993178 - 531 WP_000600725.1 glutathione-regulated potassium-efflux system oxidoreductase KefF -
EcoliRb_RS19295 (3993286) 3993286..3994617 - 1332 WP_001183207.1 MFS transporter -
EcoliRb_RS19300 (3994676) 3994676..3994963 - 288 WP_001682556.1 ferredoxin-like protein FixX -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(2-103)

Antitoxin

(8-77)


Sequences


Toxin        


Download         Length: 105 a.a.        Molecular weight: 11711.72 Da        Isoelectric Point: 9.0851

>T40622 WP_001160966.1 NZ_AP025682:c3989800-3989486 [Escherichia coli]
MQFTVYRSRGRNAAFPFVIDVTSDIIGEINRRIVIPLTPIERFSRIRPPERLNPILLLVDGKEYVLMTHETATVPVNALG
TKFCDASAHRTLIKGALDFMLDGI

Download         Length: 315 bp

>T40622 NZ_AP025682:c3989800-3989486 [Escherichia coli]
ATGCAATTTACGGTATACCGCAGTCGCGGCAGGAACGCCGCGTTTCCCTTTGTTATTGATGTTACCAGCGACATTATTGG
TGAGATTAATCGCCGTATCGTTATTCCATTAACACCTATTGAACGATTTAGCCGTATTCGCCCACCAGAACGGCTTAACC
CAATCCTTTTACTGGTAGACGGCAAAGAATATGTGCTCATGACGCATGAGACTGCAACTGTTCCAGTTAACGCGCTGGGA
ACGAAATTTTGCGATGCCAGCGCGCACCGAACGTTGATTAAAGGAGCATTAGATTTTATGCTCGACGGGATTTAA

Antitoxin


Download         Length: 78 a.a.        Molecular weight: 8530.53 Da        Isoelectric Point: 5.8062

>AT40622 WP_000125566.1 NZ_AP025682:c3990036-3989803 [Escherichia coli]
MTAKRTTQSVTVTVDRELVNRARDAGLNMSATLTVALNAELKKHAATRWREENAEAIAALNQLADETGCFSDEYRSF

Download         Length: 234 bp

>AT40622 NZ_AP025682:c3990036-3989803 [Escherichia coli]
ATGACTGCAAAACGTACCACACAAAGTGTGACCGTCACCGTCGACCGTGAGTTAGTCAATCGCGCTCGTGATGCAGGCTT
AAATATGAGCGCCACCCTTACGGTTGCGCTCAATGCTGAACTTAAAAAACATGCAGCAACACGTTGGCGTGAAGAGAACG
CAGAAGCTATCGCTGCGTTAAATCAATTGGCTGATGAAACCGGATGTTTCTCTGATGAGTACCGGAGCTTCTAG

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB A0A829G815


Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LTM9

References