Detailed information of TA system
Overview
TA module
Type | II | Classification (family/domain) | ccdAB/CcdA(antitoxin) |
Location | 3989486..3990036 | Replicon | chromosome |
Accession | NZ_AP025682 | ||
Organism | Escherichia coli strain Rb-50 |
Toxin (Protein)
Gene name | ccdB | Uniprot ID | S1PDG4 |
Locus tag | EcoliRb_RS19270 | Protein ID | WP_001160966.1 |
Coordinates | 3989486..3989800 (-) | Length | 105 a.a. |
Antitoxin (Protein)
Gene name | ccdA | Uniprot ID | V0VEX8 |
Locus tag | EcoliRb_RS19275 | Protein ID | WP_000125566.1 |
Coordinates | 3989803..3990036 (-) | Length | 78 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
EcoliRb_RS19245 (3985161) | 3985161..3986447 | + | 1287 | WP_000800457.1 | peptidylprolyl isomerase SurA | - |
EcoliRb_RS19250 (3986447) | 3986447..3987436 | + | 990 | WP_000241226.1 | 4-hydroxythreonine-4-phosphate dehydrogenase PdxA | - |
EcoliRb_RS19255 (3987433) | 3987433..3988254 | + | 822 | WP_137500865.1 | 16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))- dimethyltransferase RsmA | - |
EcoliRb_RS19260 (3988257) | 3988257..3988634 | + | 378 | WP_000610901.1 | Co2+/Mg2+ efflux protein ApaG | - |
EcoliRb_RS19265 (3988641) | 3988641..3989489 | + | 849 | WP_000257181.1 | bis(5'-nucleosyl)-tetraphosphatase (symmetrical) ApaH | - |
EcoliRb_RS19270 (3989486) | 3989486..3989800 | - | 315 | WP_001160966.1 | CcdB family protein | Toxin |
EcoliRb_RS19275 (3989803) | 3989803..3990036 | - | 234 | WP_000125566.1 | type II toxin-antitoxin system CcdA family antitoxin | Antitoxin |
EcoliRb_RS19280 (3990122) | 3990122..3990601 | - | 480 | WP_000624375.1 | type 3 dihydrofolate reductase | - |
EcoliRb_RS19285 (3990793) | 3990793..3992655 | - | 1863 | WP_000377124.1 | glutathione-regulated potassium-efflux system protein KefC | - |
EcoliRb_RS19290 (3992648) | 3992648..3993178 | - | 531 | WP_000600725.1 | glutathione-regulated potassium-efflux system oxidoreductase KefF | - |
EcoliRb_RS19295 (3993286) | 3993286..3994617 | - | 1332 | WP_001183207.1 | MFS transporter | - |
EcoliRb_RS19300 (3994676) | 3994676..3994963 | - | 288 | WP_001682556.1 | ferredoxin-like protein FixX | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 105 a.a. Molecular weight: 11711.72 Da Isoelectric Point: 9.0851
>T40622 WP_001160966.1 NZ_AP025682:c3989800-3989486 [Escherichia coli]
MQFTVYRSRGRNAAFPFVIDVTSDIIGEINRRIVIPLTPIERFSRIRPPERLNPILLLVDGKEYVLMTHETATVPVNALG
TKFCDASAHRTLIKGALDFMLDGI
MQFTVYRSRGRNAAFPFVIDVTSDIIGEINRRIVIPLTPIERFSRIRPPERLNPILLLVDGKEYVLMTHETATVPVNALG
TKFCDASAHRTLIKGALDFMLDGI
Download Length: 315 bp
>T40622 NZ_AP025682:c3989800-3989486 [Escherichia coli]
ATGCAATTTACGGTATACCGCAGTCGCGGCAGGAACGCCGCGTTTCCCTTTGTTATTGATGTTACCAGCGACATTATTGG
TGAGATTAATCGCCGTATCGTTATTCCATTAACACCTATTGAACGATTTAGCCGTATTCGCCCACCAGAACGGCTTAACC
CAATCCTTTTACTGGTAGACGGCAAAGAATATGTGCTCATGACGCATGAGACTGCAACTGTTCCAGTTAACGCGCTGGGA
ACGAAATTTTGCGATGCCAGCGCGCACCGAACGTTGATTAAAGGAGCATTAGATTTTATGCTCGACGGGATTTAA
ATGCAATTTACGGTATACCGCAGTCGCGGCAGGAACGCCGCGTTTCCCTTTGTTATTGATGTTACCAGCGACATTATTGG
TGAGATTAATCGCCGTATCGTTATTCCATTAACACCTATTGAACGATTTAGCCGTATTCGCCCACCAGAACGGCTTAACC
CAATCCTTTTACTGGTAGACGGCAAAGAATATGTGCTCATGACGCATGAGACTGCAACTGTTCCAGTTAACGCGCTGGGA
ACGAAATTTTGCGATGCCAGCGCGCACCGAACGTTGATTAAAGGAGCATTAGATTTTATGCTCGACGGGATTTAA
Antitoxin
Download Length: 78 a.a. Molecular weight: 8530.53 Da Isoelectric Point: 5.8062
>AT40622 WP_000125566.1 NZ_AP025682:c3990036-3989803 [Escherichia coli]
MTAKRTTQSVTVTVDRELVNRARDAGLNMSATLTVALNAELKKHAATRWREENAEAIAALNQLADETGCFSDEYRSF
MTAKRTTQSVTVTVDRELVNRARDAGLNMSATLTVALNAELKKHAATRWREENAEAIAALNQLADETGCFSDEYRSF
Download Length: 234 bp
>AT40622 NZ_AP025682:c3990036-3989803 [Escherichia coli]
ATGACTGCAAAACGTACCACACAAAGTGTGACCGTCACCGTCGACCGTGAGTTAGTCAATCGCGCTCGTGATGCAGGCTT
AAATATGAGCGCCACCCTTACGGTTGCGCTCAATGCTGAACTTAAAAAACATGCAGCAACACGTTGGCGTGAAGAGAACG
CAGAAGCTATCGCTGCGTTAAATCAATTGGCTGATGAAACCGGATGTTTCTCTGATGAGTACCGGAGCTTCTAG
ATGACTGCAAAACGTACCACACAAAGTGTGACCGTCACCGTCGACCGTGAGTTAGTCAATCGCGCTCGTGATGCAGGCTT
AAATATGAGCGCCACCCTTACGGTTGCGCTCAATGCTGAACTTAAAAAACATGCAGCAACACGTTGGCGTGAAGAGAACG
CAGAAGCTATCGCTGCGTTAAATCAATTGGCTGATGAAACCGGATGTTTCTCTGATGAGTACCGGAGCTTCTAG
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A829G815 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A7U9LTM9 |