Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 1947794..1948625 Replicon chromosome
Accession NZ_AP025675
Organism Escherichia coli strain Rb-3

Toxin (Protein)


Gene name yeeV Uniprot ID S1P968
Locus tag MWM15_RS09125 Protein ID WP_000854814.1
Coordinates 1947794..1948168 (-) Length 125 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID -
Locus tag MWM15_RS09130 Protein ID WP_024174331.1
Coordinates 1948257..1948625 (-) Length 123 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MWM15_RS09085 (1943190) 1943190..1944356 + 1167 WP_244337980.1 serine-type D-Ala-D-Ala carboxypeptidase DacD -
MWM15_RS09090 (1944475) 1944475..1944948 + 474 WP_001105376.1 DNA gyrase inhibitor SbmC -
MWM15_RS09095 (1945146) 1945146..1946204 + 1059 WP_001200890.1 FUSC family protein -
MWM15_RS09100 (1946376) 1946376..1946705 + 330 WP_000450409.1 DUF496 family protein -
MWM15_RS09105 (1946806) 1946806..1947129 - 324 WP_223216378.1 EutP/PduV family microcompartment system protein -
MWM15_RS09110 (1947108) 1947108..1947188 + 81 WP_023441679.1 hypothetical protein -
MWM15_RS09115 (1947477) 1947477..1947557 - 81 Protein_1789 hypothetical protein -
MWM15_RS09120 (1947603) 1947603..1947797 - 195 WP_000988601.1 DUF5983 family protein -
MWM15_RS09125 (1947794) 1947794..1948168 - 375 WP_000854814.1 type IV toxin-antitoxin system cytoskeleton-binding toxin CbtA Toxin
MWM15_RS09130 (1948257) 1948257..1948625 - 369 WP_024174331.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
MWM15_RS09135 (1948699) 1948699..1948920 - 222 WP_000692346.1 DUF987 domain-containing protein -
MWM15_RS09140 (1948989) 1948989..1949465 - 477 WP_001541535.1 RadC family protein -
MWM15_RS09145 (1949481) 1949481..1949954 - 474 WP_000855074.1 antirestriction protein -
MWM15_RS09150 (1950217) 1950217..1951038 - 822 WP_021580859.1 DUF932 domain-containing protein -
MWM15_RS09155 (1951259) 1951259..1951669 - 411 WP_000846704.1 hypothetical protein -
MWM15_RS09160 (1951685) 1951685..1952362 - 678 WP_001362823.1 hypothetical protein -
MWM15_RS09165 (1952498) 1952498..1953568 - 1071 WP_000102631.1 patatin-like phospholipase family protein -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(1-112)

Antitoxin

(19-117)


Sequences


Toxin        


Download         Length: 125 a.a.        Molecular weight: 13898.94 Da        Isoelectric Point: 7.8522

>T40549 WP_000854814.1 NZ_AP025675:c1948168-1947794 [Escherichia coli]
MKTLPVLPGQAASSRPSPVEIWQILLSRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKYPEAK

Download         Length: 375 bp

>T40549 NZ_AP025675:c1948168-1947794 [Escherichia coli]
ATGAAAACATTACCTGTATTACCCGGGCAGGCGGCCAGTTCTCGCCCGTCTCCTGTTGAAATCTGGCAGATACTGCTGTC
CCGACTGCTGGACCAGCACTACGGCCTCACACTGAATGACACACCGTTTGCCGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGATGCGGTGAACTTTCTCGTGGAAAAATACGCGCTGGTGCGTACCGACCAGCCGGGATTC
AGCGCCTGTACCCGCTCTCAGTTAATAAACAGCATCGATATCCTCCGGGCTCGCAGGGCGACCGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGTAAGTATCCGGAGGCGAAATGA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13603.42 Da        Isoelectric Point: 6.7386

>AT40549 WP_024174331.1 NZ_AP025675:c1948625-1948257 [Escherichia coli]
VSDTLPGTTHPDDNHDRLWWGLPCTVTPCFGARLVQKGNRLHYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCEADTLGSCGYVYLAVYPTPETKT

Download         Length: 369 bp

>AT40549 NZ_AP025675:c1948625-1948257 [Escherichia coli]
GTGTCAGACACACTGCCCGGGACAACGCATCCCGACGACAATCACGACCGCCTCTGGTGGGGACTGCCCTGCACCGTGAC
GCCCTGTTTCGGGGCACGTCTGGTGCAGAAGGGTAACCGGTTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGCCGGT
TCAGCGATGCAGATGCATACCACCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTGACACTGTATGCGAAGGGGCTGACCTGTGAAGCCGACACCCTCGGCTCCTG
TGGTTACGTTTATCTGGCTGTTTATCCGACGCCCGAAACGAAAACGTAA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB A0A829FY50


Antitoxin

Source ID Structure

References