Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 1927982..1928813 Replicon chromosome
Accession NZ_AP025662
Organism Escherichia coli strain TUM20902

Toxin (Protein)


Gene name yeeV Uniprot ID S1P968
Locus tag M2084_RS09070 Protein ID WP_000854814.1
Coordinates 1927982..1928356 (-) Length 125 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID B3Y195
Locus tag M2084_RS09075 Protein ID WP_001285585.1
Coordinates 1928445..1928813 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M2084_RS09030 (1923378) 1923378..1924544 + 1167 WP_000830150.1 serine-type D-Ala-D-Ala carboxypeptidase DacD -
M2084_RS09035 (1924663) 1924663..1925136 + 474 WP_001105389.1 DNA gyrase inhibitor SbmC -
M2084_RS09040 (1925334) 1925334..1926392 + 1059 WP_001200891.1 FUSC family protein -
M2084_RS09045 (1926564) 1926564..1926893 + 330 WP_000450409.1 DUF496 family protein -
M2084_RS09050 (1926994) 1926994..1927128 - 135 WP_001297944.1 EutP/PduV family microcompartment system protein -
M2084_RS09055 (1927248) 1927248..1927376 + 129 Protein_1779 transposase domain-containing protein -
M2084_RS09060 (1927665) 1927665..1927745 - 81 Protein_1780 hypothetical protein -
M2084_RS09065 (1927791) 1927791..1927985 - 195 WP_000988600.1 DUF5983 family protein -
M2084_RS09070 (1927982) 1927982..1928356 - 375 WP_000854814.1 type IV toxin-antitoxin system cytoskeleton-binding toxin CbtA Toxin
M2084_RS09075 (1928445) 1928445..1928813 - 369 WP_001285585.1 type IV toxin-antitoxin system cytoskeleton bundling-enhancing antitoxin CbeA Antitoxin
M2084_RS09080 (1928887) 1928887..1929108 - 222 WP_000692323.1 DUF987 domain-containing protein -
M2084_RS09085 (1929171) 1929171..1929647 - 477 WP_001186726.1 RadC family protein -
M2084_RS09090 (1929663) 1929663..1930142 - 480 WP_000860087.1 antirestriction protein -
M2084_RS09095 (1930224) 1930224..1931042 - 819 WP_001234629.1 DUF932 domain-containing protein -
M2084_RS09100 (1931142) 1931142..1931375 - 234 WP_001119729.1 DUF905 family protein -
M2084_RS09105 (1931454) 1931454..1931909 - 456 WP_000581504.1 IrmA family protein -
M2084_RS09110 (1931985) 1931985..1933709 - 1725 Protein_1790 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 125 a.a.        Molecular weight: 13898.94 Da        Isoelectric Point: 7.8522

>T40513 WP_000854814.1 NZ_AP025662:c1928356-1927982 [Escherichia coli]
MKTLPVLPGQAASSRPSPVEIWQILLSRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKYPEAK

Download         Length: 375 bp

>T40513 NZ_AP025662:c1928356-1927982 [Escherichia coli]
ATGAAAACATTACCTGTATTACCCGGGCAGGCGGCCAGTTCTCGCCCGTCTCCTGTTGAAATCTGGCAGATACTGCTGTC
CCGACTGCTGGACCAGCACTATGGCCTCACACTGAATGACACACCTTTTGCCGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGATGCGGTGAACTTTCTCGTGGAAAAATACGCGCTGGTGCGTACCGACCAGCCGGGATTC
AGCGCCTGTACCCGCTCTCAGTTAATAAACAGTATTGATATCCTCCGGGCACGCCGGGCAACCGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGTAAGTATCCGGAGGCGAAATGA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13593.48 Da        Isoelectric Point: 6.3139

>AT40513 WP_001285585.1 NZ_AP025662:c1928813-1928445 [Escherichia coli]
VSDTLPGTTLPDDNHDRPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGLFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCKADTLSSCGYVYLAVYPTPEMKN

Download         Length: 369 bp

>AT40513 NZ_AP025662:c1928813-1928445 [Escherichia coli]
GTGTCAGACACACTCCCCGGGACAACACTTCCCGACGACAATCACGACCGCCCCTGGTGGGGGCTGCCCTGCACCGTGAC
GCCCTGTTTCGGGGCACGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGCCTGT
TCAGCGATGCAGATGCGTACCACCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACGCTGTATGCAAAAGGGCTGACCTGCAAAGCCGATACCCTCAGCAGTTG
TGGTTACGTTTATCTGGCTGTTTATCCGACGCCCGAAATGAAAAATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829FY50

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LW60

References