Detailed information of TA system
Overview
TA module
| Type | IV | Classification (family/domain) | yeeUV (cbtA-cbeA)/CbtA-CbeA |
| Location | 1928216..1929047 | Replicon | chromosome |
| Accession | NZ_AP025657 | ||
| Organism | Escherichia coli strain TUM13867 | ||
Toxin (Protein)
| Gene name | yeeV | Uniprot ID | S1P968 |
| Locus tag | MWM17_RS09070 | Protein ID | WP_000854814.1 |
| Coordinates | 1928216..1928590 (-) | Length | 125 a.a. |
Antitoxin (Protein)
| Gene name | yeeU | Uniprot ID | A0A2T3TJJ3 |
| Locus tag | MWM17_RS09075 | Protein ID | WP_001285590.1 |
| Coordinates | 1928679..1929047 (-) | Length | 123 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| MWM17_RS09030 (1923612) | 1923612..1924778 | + | 1167 | WP_000830150.1 | serine-type D-Ala-D-Ala carboxypeptidase DacD | - |
| MWM17_RS09035 (1924897) | 1924897..1925370 | + | 474 | WP_001105389.1 | DNA gyrase inhibitor SbmC | - |
| MWM17_RS09040 (1925568) | 1925568..1926626 | + | 1059 | WP_001200891.1 | FUSC family protein | - |
| MWM17_RS09045 (1926798) | 1926798..1927127 | + | 330 | WP_000450409.1 | DUF496 family protein | - |
| MWM17_RS09050 (1927228) | 1927228..1927362 | - | 135 | WP_001297944.1 | EutP/PduV family microcompartment system protein | - |
| MWM17_RS09055 (1927482) | 1927482..1927610 | + | 129 | Protein_1779 | transposase domain-containing protein | - |
| MWM17_RS09060 (1927899) | 1927899..1927979 | - | 81 | Protein_1780 | hypothetical protein | - |
| MWM17_RS09065 (1928025) | 1928025..1928219 | - | 195 | WP_000988600.1 | DUF5983 family protein | - |
| MWM17_RS09070 (1928216) | 1928216..1928590 | - | 375 | WP_000854814.1 | type IV toxin-antitoxin system cytoskeleton-binding toxin CbtA | Toxin |
| MWM17_RS09075 (1928679) | 1928679..1929047 | - | 369 | WP_001285590.1 | type IV toxin-antitoxin system cytoskeleton bundling-enhancing antitoxin CbeA | Antitoxin |
| MWM17_RS09080 (1929121) | 1929121..1929342 | - | 222 | WP_000692323.1 | DUF987 domain-containing protein | - |
| MWM17_RS09085 (1929405) | 1929405..1929881 | - | 477 | WP_001186726.1 | RadC family protein | - |
| MWM17_RS09090 (1929897) | 1929897..1930376 | - | 480 | WP_171920564.1 | antirestriction protein | - |
| MWM17_RS09095 (1930458) | 1930458..1931276 | - | 819 | WP_244359104.1 | DUF932 domain-containing protein | - |
| MWM17_RS09100 (1931376) | 1931376..1931609 | - | 234 | WP_001119729.1 | DUF905 family protein | - |
| MWM17_RS09105 (1931688) | 1931688..1932143 | - | 456 | WP_000581504.1 | IrmA family protein | - |
| MWM17_RS09110 (1932219) | 1932219..1933943 | - | 1725 | Protein_1790 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 125 a.a. Molecular weight: 13898.94 Da Isoelectric Point: 7.8522
>T40475 WP_000854814.1 NZ_AP025657:c1928590-1928216 [Escherichia coli]
MKTLPVLPGQAASSRPSPVEIWQILLSRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKYPEAK
MKTLPVLPGQAASSRPSPVEIWQILLSRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKYPEAK
Download Length: 375 bp
>T40475 NZ_AP025657:c1928590-1928216 [Escherichia coli]
ATGAAAACATTACCTGTATTACCCGGGCAGGCGGCCAGTTCTCGCCCGTCTCCTGTTGAAATCTGGCAGATACTTCTGTC
CCGACTGCTGGACCAGCACTACGGCCTCACACTGAATGACACACCGTTTGCCGATGAACGTGTGATCGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGATGCGGTGAACTTTCTCGTGGAAAAATACGCGCTGGTGCGTACCGACCAGCCGGGATTC
AGCGCCTGTACCCGCTCTCAGTTAATAAACAGTATTGATATCCTCCGGGCACGCCGGGCAACCGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGTAAGTATCCGGAGGCGAAATGA
ATGAAAACATTACCTGTATTACCCGGGCAGGCGGCCAGTTCTCGCCCGTCTCCTGTTGAAATCTGGCAGATACTTCTGTC
CCGACTGCTGGACCAGCACTACGGCCTCACACTGAATGACACACCGTTTGCCGATGAACGTGTGATCGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGATGCGGTGAACTTTCTCGTGGAAAAATACGCGCTGGTGCGTACCGACCAGCCGGGATTC
AGCGCCTGTACCCGCTCTCAGTTAATAAACAGTATTGATATCCTCCGGGCACGCCGGGCAACCGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGTAAGTATCCGGAGGCGAAATGA
Antitoxin
Download Length: 123 a.a. Molecular weight: 13608.50 Da Isoelectric Point: 6.6242
>AT40475 WP_001285590.1 NZ_AP025657:c1929047-1928679 [Escherichia coli]
VSDTLPGTTLPDDNHDRPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGLYSNADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCKADTLSSCGYVYLAVYPTPEMKN
VSDTLPGTTLPDDNHDRPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGLYSNADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCKADTLSSCGYVYLAVYPTPEMKN
Download Length: 369 bp
>AT40475 NZ_AP025657:c1929047-1928679 [Escherichia coli]
GTGTCAGACACACTCCCCGGGACAACACTTCCCGACGACAATCACGACCGCCCCTGGTGGGGGCTGCCCTGCACCGTGAC
GCCCTGTTTCGGGGCACGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGCCTGT
ACAGCAATGCAGATGCGTACCACCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACGCTGTATGCAAAAGGGCTGACCTGCAAAGCCGATACCCTCAGCAGTTG
TGGTTACGTTTATCTGGCTGTTTATCCGACGCCCGAAATGAAAAATTAA
GTGTCAGACACACTCCCCGGGACAACACTTCCCGACGACAATCACGACCGCCCCTGGTGGGGGCTGCCCTGCACCGTGAC
GCCCTGTTTCGGGGCACGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGCCTGT
ACAGCAATGCAGATGCGTACCACCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACGCTGTATGCAAAAGGGCTGACCTGCAAAGCCGATACCCTCAGCAGTTG
TGGTTACGTTTATCTGGCTGTTTATCCGACGCCCGAAATGAAAAATTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A829FY50 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A2T3TJJ3 |