Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 1928216..1929047 Replicon chromosome
Accession NZ_AP025657
Organism Escherichia coli strain TUM13867

Toxin (Protein)


Gene name yeeV Uniprot ID S1P968
Locus tag MWM17_RS09070 Protein ID WP_000854814.1
Coordinates 1928216..1928590 (-) Length 125 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A2T3TJJ3
Locus tag MWM17_RS09075 Protein ID WP_001285590.1
Coordinates 1928679..1929047 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MWM17_RS09030 (1923612) 1923612..1924778 + 1167 WP_000830150.1 serine-type D-Ala-D-Ala carboxypeptidase DacD -
MWM17_RS09035 (1924897) 1924897..1925370 + 474 WP_001105389.1 DNA gyrase inhibitor SbmC -
MWM17_RS09040 (1925568) 1925568..1926626 + 1059 WP_001200891.1 FUSC family protein -
MWM17_RS09045 (1926798) 1926798..1927127 + 330 WP_000450409.1 DUF496 family protein -
MWM17_RS09050 (1927228) 1927228..1927362 - 135 WP_001297944.1 EutP/PduV family microcompartment system protein -
MWM17_RS09055 (1927482) 1927482..1927610 + 129 Protein_1779 transposase domain-containing protein -
MWM17_RS09060 (1927899) 1927899..1927979 - 81 Protein_1780 hypothetical protein -
MWM17_RS09065 (1928025) 1928025..1928219 - 195 WP_000988600.1 DUF5983 family protein -
MWM17_RS09070 (1928216) 1928216..1928590 - 375 WP_000854814.1 type IV toxin-antitoxin system cytoskeleton-binding toxin CbtA Toxin
MWM17_RS09075 (1928679) 1928679..1929047 - 369 WP_001285590.1 type IV toxin-antitoxin system cytoskeleton bundling-enhancing antitoxin CbeA Antitoxin
MWM17_RS09080 (1929121) 1929121..1929342 - 222 WP_000692323.1 DUF987 domain-containing protein -
MWM17_RS09085 (1929405) 1929405..1929881 - 477 WP_001186726.1 RadC family protein -
MWM17_RS09090 (1929897) 1929897..1930376 - 480 WP_171920564.1 antirestriction protein -
MWM17_RS09095 (1930458) 1930458..1931276 - 819 WP_244359104.1 DUF932 domain-containing protein -
MWM17_RS09100 (1931376) 1931376..1931609 - 234 WP_001119729.1 DUF905 family protein -
MWM17_RS09105 (1931688) 1931688..1932143 - 456 WP_000581504.1 IrmA family protein -
MWM17_RS09110 (1932219) 1932219..1933943 - 1725 Protein_1790 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 125 a.a.        Molecular weight: 13898.94 Da        Isoelectric Point: 7.8522

>T40475 WP_000854814.1 NZ_AP025657:c1928590-1928216 [Escherichia coli]
MKTLPVLPGQAASSRPSPVEIWQILLSRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKYPEAK

Download         Length: 375 bp

>T40475 NZ_AP025657:c1928590-1928216 [Escherichia coli]
ATGAAAACATTACCTGTATTACCCGGGCAGGCGGCCAGTTCTCGCCCGTCTCCTGTTGAAATCTGGCAGATACTTCTGTC
CCGACTGCTGGACCAGCACTACGGCCTCACACTGAATGACACACCGTTTGCCGATGAACGTGTGATCGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGATGCGGTGAACTTTCTCGTGGAAAAATACGCGCTGGTGCGTACCGACCAGCCGGGATTC
AGCGCCTGTACCCGCTCTCAGTTAATAAACAGTATTGATATCCTCCGGGCACGCCGGGCAACCGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGTAAGTATCCGGAGGCGAAATGA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13608.50 Da        Isoelectric Point: 6.6242

>AT40475 WP_001285590.1 NZ_AP025657:c1929047-1928679 [Escherichia coli]
VSDTLPGTTLPDDNHDRPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGLYSNADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCKADTLSSCGYVYLAVYPTPEMKN

Download         Length: 369 bp

>AT40475 NZ_AP025657:c1929047-1928679 [Escherichia coli]
GTGTCAGACACACTCCCCGGGACAACACTTCCCGACGACAATCACGACCGCCCCTGGTGGGGGCTGCCCTGCACCGTGAC
GCCCTGTTTCGGGGCACGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGCCTGT
ACAGCAATGCAGATGCGTACCACCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACGCTGTATGCAAAAGGGCTGACCTGCAAAGCCGATACCCTCAGCAGTTG
TGGTTACGTTTATCTGGCTGTTTATCCGACGCCCGAAATGAAAAATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829FY50

Antitoxin

Source ID Structure
AlphaFold DB A0A2T3TJJ3

References