Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazF-pemI/MazF(toxin)
Location 3580734..3581370 Replicon chromosome
Accession NZ_AP025627
Organism Parageobacillus sp. KH3-4

Toxin (Protein)


Gene name mazF Uniprot ID L7ZVP1
Locus tag MWM02_RS18200 Protein ID WP_003253417.1
Coordinates 3580734..3581084 (-) Length 117 a.a.

Antitoxin (Protein)


Gene name pemI Uniprot ID A0A178U3Z0
Locus tag MWM02_RS18205 Protein ID WP_003253419.1
Coordinates 3581089..3581370 (-) Length 94 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MWM02_RS18185 (PspKH34_35880) 3577647..3578135 - 489 WP_064552701.1 SprT family protein -
MWM02_RS18190 3578226..3578339 + 114 WP_012748966.1 cortex morphogenetic protein CmpA -
MWM02_RS18195 (PspKH34_35890) 3578334..3580520 - 2187 WP_064552919.1 Tex family protein -
MWM02_RS18200 (PspKH34_35900) 3580734..3581084 - 351 WP_003253417.1 type II toxin-antitoxin system endoribonuclease NdoA Toxin
MWM02_RS18205 (PspKH34_35910) 3581089..3581370 - 282 WP_003253419.1 hypothetical protein Antitoxin
MWM02_RS18210 (PspKH34_35920) 3581493..3582647 - 1155 WP_244402629.1 alanine racemase -
MWM02_RS18215 (PspKH34_35930) 3582859..3583872 - 1014 WP_244402630.1 outer membrane lipoprotein carrier protein LolA -
MWM02_RS18220 (PspKH34_35940) 3583954..3584313 - 360 WP_064552704.1 holo-ACP synthase -
MWM02_RS18225 (PspKH34_35950) 3584377..3584991 + 615 WP_064552705.1 rhomboid family intramembrane serine protease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(4-111)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12992.00 Da        Isoelectric Point: 4.8781

>T40467 WP_003253417.1 NZ_AP025627:c3581084-3580734 [Parageobacillus sp. KH3-4]
MIVKRGDVYFADLSPVVGSEQGGVRPVLVIQNDIGNRFSPTVIVAAITAQIQKAKLPTHVEIDAKRYGFERDSVILLEQI
RTIDKQRLTDKITHLDDEMMDKVDEALQISLGLIDF

Download         Length: 351 bp

>T40467 NZ_AP025627:c3581084-3580734 [Parageobacillus sp. KH3-4]
TTGATTGTTAAGCGTGGCGACGTTTATTTTGCGGACCTTTCCCCGGTAGTTGGCTCGGAACAAGGAGGCGTTCGTCCGGT
ATTAGTCATTCAAAATGACATCGGAAATCGGTTTAGTCCGACGGTGATTGTGGCGGCGATTACAGCGCAAATCCAAAAAG
CAAAGCTGCCGACGCATGTCGAGATTGATGCAAAGCGTTACGGGTTTGAGCGGGATTCTGTTATTCTGCTAGAGCAAATT
CGGACGATTGATAAACAGCGGCTGACAGACAAAATTACTCACTTGGACGATGAAATGATGGATAAGGTGGATGAAGCGCT
GCAAATCAGTTTAGGACTTATAGATTTTTAA

Antitoxin


Download         Length: 94 a.a.        Molecular weight: 10631.16 Da        Isoelectric Point: 7.0142

>AT40467 WP_003253419.1 NZ_AP025627:c3581370-3581089 [Parageobacillus sp. KH3-4]
VSESSATTEIVVRLPQALVTELDVLVKQENGNRNDLIYQATKMYIRERKKRQIREAMRRGYMEMAKINLSIASEAFLAEY
EADHTVERLVSGG

Download         Length: 282 bp

>AT40467 NZ_AP025627:c3581370-3581089 [Parageobacillus sp. KH3-4]
GTGTCGGAATCTAGCGCAACAACGGAAATCGTCGTTCGTTTGCCTCAAGCACTAGTAACGGAATTGGATGTGCTTGTGAA
ACAAGAGAACGGCAACCGCAATGATCTCATTTATCAAGCAACTAAAATGTACATTCGCGAACGGAAAAAACGGCAAATCC
GCGAGGCGATGAGACGCGGCTATATGGAAATGGCGAAAATCAATTTATCTATTGCTTCAGAGGCGTTTCTTGCAGAATAT
GAAGCCGACCACACCGTTGAACGTTTAGTTAGCGGGGGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9ERQ4

Antitoxin

Source ID Structure
AlphaFold DB A0A178U3Z0

References