40466

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazF-pemI/MazF(toxin)
Location 231266..231902 Replicon chromosome
Accession NZ_AP025625
Organism Parageobacillus caldoxylosilyticus strain KH3-5

Toxin (Protein)


Gene name mazF Uniprot ID L7ZVP1
Locus tag MWM03_RS01285 Protein ID WP_003253417.1
Coordinates 231552..231902 (+) Length 117 a.a.

Antitoxin (Protein)


Gene name pemI Uniprot ID A0A023DG03
Locus tag MWM03_RS01280 Protein ID WP_017435868.1
Coordinates 231266..231547 (+) Length 94 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MWM03_RS01255 (PcaKH35_02150) 227272..227520 + 249 WP_042409264.1 hypothetical protein -
MWM03_RS01260 (PcaKH35_02160) 227587..228204 - 618 WP_081161017.1 rhomboid family intramembrane serine protease -
MWM03_RS01265 (PcaKH35_02170) 228338..228697 + 360 WP_017435871.1 holo-ACP synthase -
MWM03_RS01270 (PcaKH35_02180) 228780..229793 + 1014 WP_042409268.1 outer membrane lipoprotein carrier protein LolA -
MWM03_RS01275 (PcaKH35_02190) 229986..231152 + 1167 WP_026078517.1 alanine racemase -
MWM03_RS01280 (PcaKH35_02200) 231266..231547 + 282 WP_017435868.1 hypothetical protein Antitoxin
MWM03_RS01285 (PcaKH35_02210) 231552..231902 + 351 WP_003253417.1 type II toxin-antitoxin system endoribonuclease NdoA Toxin
MWM03_RS01290 (PcaKH35_02220) 232362..234548 + 2187 WP_081161036.1 Tex family protein -
MWM03_RS01295 234543..234656 - 114 WP_017435866.1 cortex morphogenetic protein CmpA -
MWM03_RS01300 (PcaKH35_02230) 234746..235216 + 471 WP_244380500.1 SprT family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(4-111)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12992.00 Da        Isoelectric Point: 4.8781

>T40466 WP_003253417.1 NZ_AP025625:231552-231902 [Parageobacillus caldoxylosilyticus]
MIVKRGDVYFADLSPVVGSEQGGVRPVLVIQNDIGNRFSPTVIVAAITAQIQKAKLPTHVEIDAKRYGFERDSVILLEQI
RTIDKQRLTDKITHLDDEMMDKVDEALQISLGLIDF

Download         Length: 351 bp

>T40466 NZ_AP025625:231552-231902 [Parageobacillus caldoxylosilyticus]
TTGATTGTTAAACGTGGCGACGTTTATTTTGCGGACCTTTCCCCGGTAGTTGGCTCAGAGCAGGGCGGTGTCCGCCCCGT
ATTGGTCATCCAAAATGACATTGGCAATCGCTTTAGCCCAACGGTGATCGTAGCGGCGATTACAGCGCAAATTCAAAAAG
CGAAGCTGCCAACGCACGTTGAAATTGATGCAAAACGCTACGGGTTTGAGCGGGATTCCGTCATTTTGCTAGAACAAATT
CGGACAATTGATAAACAGCGGCTCACGGATAAAATCACCCATTTAGATGATGAAATGATGGATAAAGTGGATGAAGCGCT
GCAGATCAGTTTAGGACTTATCGATTTTTAA

Antitoxin


Download         Length: 94 a.a.        Molecular weight: 10661.19 Da        Isoelectric Point: 7.0147

>AT40466 WP_017435868.1 NZ_AP025625:231266-231547 [Parageobacillus caldoxylosilyticus]
VSESSATTEIVVRLPQSLVTELDVLVKQENGNRNELIYQATKMYIRERKKRQIREAMRRGYMEMAKINLSIASEAFLAEY
EADHTVERLVSGG

Download         Length: 282 bp

>AT40466 NZ_AP025625:231266-231547 [Parageobacillus caldoxylosilyticus]
GTGTCGGAGTCTAGCGCAACAACGGAAATCGTCGTTCGTTTGCCTCAATCATTAGTAACAGAATTAGATGTGCTGGTGAA
ACAAGAAAACGGCAATCGGAATGAACTGATTTACCAAGCGACGAAAATGTATATTCGTGAGCGGAAGAAACGGCAAATCC
GCGAAGCGATGAGACGAGGCTACATGGAAATGGCAAAAATCAATTTATCGATCGCTTCAGAAGCGTTTCTTGCAGAATAT
GAAGCCGACCACACCGTTGAACGTTTAGTTAGCGGGGGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9ERQ4

Antitoxin

Source ID Structure
AlphaFold DB A0A023DG03

References