Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazF-pemI/MazF(toxin)
Location 239577..240213 Replicon chromosome
Accession NZ_AP025624
Organism Parageobacillus caldoxylosilyticus strain KH1-6

Toxin (Protein)


Gene name mazF Uniprot ID L7ZVP1
Locus tag JPge_RS01330 Protein ID WP_003253417.1
Coordinates 239863..240213 (+) Length 117 a.a.

Antitoxin (Protein)


Gene name pemI Uniprot ID A0A023DG03
Locus tag JPge_RS01325 Protein ID WP_017435868.1
Coordinates 239577..239858 (+) Length 94 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JPge_RS01300 (PcaKH16_02290) 235583..235831 + 249 WP_042409264.1 hypothetical protein -
JPge_RS01305 (PcaKH16_02300) 235898..236515 - 618 WP_081161017.1 rhomboid family intramembrane serine protease -
JPge_RS01310 (PcaKH16_02310) 236649..237008 + 360 WP_017435871.1 holo-ACP synthase -
JPge_RS01315 (PcaKH16_02320) 237091..238104 + 1014 WP_042409268.1 outer membrane lipoprotein carrier protein LolA -
JPge_RS01320 (PcaKH16_02330) 238297..239463 + 1167 WP_026078517.1 alanine racemase -
JPge_RS01325 (PcaKH16_02340) 239577..239858 + 282 WP_017435868.1 hypothetical protein Antitoxin
JPge_RS01330 (PcaKH16_02350) 239863..240213 + 351 WP_003253417.1 type II toxin-antitoxin system endoribonuclease NdoA Toxin
JPge_RS01335 (PcaKH16_02360) 240673..242859 + 2187 WP_081161036.1 Tex family protein -
JPge_RS01340 242854..242967 - 114 WP_017435866.1 cortex morphogenetic protein CmpA -
JPge_RS01345 (PcaKH16_02370) 243057..243527 + 471 WP_017435865.1 SprT family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(4-111)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12992.00 Da        Isoelectric Point: 4.8781

>T40465 WP_003253417.1 NZ_AP025624:239863-240213 [Parageobacillus caldoxylosilyticus]
MIVKRGDVYFADLSPVVGSEQGGVRPVLVIQNDIGNRFSPTVIVAAITAQIQKAKLPTHVEIDAKRYGFERDSVILLEQI
RTIDKQRLTDKITHLDDEMMDKVDEALQISLGLIDF

Download         Length: 351 bp

>T40465 NZ_AP025624:239863-240213 [Parageobacillus caldoxylosilyticus]
TTGATTGTTAAACGTGGCGACGTTTATTTTGCGGACCTTTCCCCGGTAGTTGGCTCAGAGCAGGGCGGTGTCCGCCCCGT
ATTGGTCATCCAAAATGACATTGGCAATCGCTTTAGCCCAACGGTGATCGTAGCGGCGATTACAGCGCAAATTCAAAAAG
CGAAGCTGCCAACGCACGTTGAAATTGATGCAAAACGCTACGGGTTTGAGCGGGATTCCGTCATTTTGCTAGAACAAATT
CGGACAATTGATAAACAGCGGCTCACGGATAAAATCACCCATTTAGATGATGAAATGATGGATAAAGTGGATGAAGCGCT
GCAGATCAGTTTAGGACTTATCGATTTTTAA

Antitoxin


Download         Length: 94 a.a.        Molecular weight: 10661.19 Da        Isoelectric Point: 7.0147

>AT40465 WP_017435868.1 NZ_AP025624:239577-239858 [Parageobacillus caldoxylosilyticus]
VSESSATTEIVVRLPQSLVTELDVLVKQENGNRNELIYQATKMYIRERKKRQIREAMRRGYMEMAKINLSIASEAFLAEY
EADHTVERLVSGG

Download         Length: 282 bp

>AT40465 NZ_AP025624:239577-239858 [Parageobacillus caldoxylosilyticus]
GTGTCGGAGTCTAGCGCAACAACGGAAATCGTCGTTCGTTTGCCTCAATCATTAGTAACAGAATTAGATGTGCTGGTGAA
ACAAGAAAACGGCAATCGGAATGAACTGATTTACCAAGCGACGAAAATGTATATTCGTGAGCGGAAGAAACGGCAAATCC
GCGAAGCGATGAGACGAGGCTACATGGAAATGGCAAAAATCAATTTATCGATCGCTTCAGAAGCGTTTCTTGCAGAATAT
GAAGCCGACCACACCGTTGAACGTTTAGTTAGCGGGGGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9ERQ4

Antitoxin

Source ID Structure
AlphaFold DB A0A023DG03

References