Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) mazF-pemI/MazF(toxin)
Location 3532774..3533410 Replicon chromosome
Accession NZ_AP025621
Organism Parageobacillus thermoglucosidasius strain BH4-1

Toxin (Protein)


Gene name mazF Uniprot ID L7ZVP1
Locus tag MWM14_RS17785 Protein ID WP_003253417.1
Coordinates 3532774..3533124 (-) Length 117 a.a.

Antitoxin (Protein)


Gene name pemI Uniprot ID A0A178U3Z0
Locus tag MWM14_RS17790 Protein ID WP_003253419.1
Coordinates 3533129..3533410 (-) Length 94 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MWM14_RS17770 (PthBH41_34630) 3529714..3530181 - 468 WP_003253403.1 SprT family protein -
MWM14_RS17775 3530269..3530382 + 114 WP_013401775.1 cortex morphogenetic protein CmpA -
MWM14_RS17780 (PthBH41_34640) 3530377..3532563 - 2187 WP_244410687.1 Tex family protein -
MWM14_RS17785 (PthBH41_34650) 3532774..3533124 - 351 WP_003253417.1 type II toxin-antitoxin system endoribonuclease NdoA Toxin
MWM14_RS17790 (PthBH41_34660) 3533129..3533410 - 282 WP_003253419.1 hypothetical protein Antitoxin
MWM14_RS17795 (PthBH41_34670) 3533533..3534687 - 1155 WP_003253421.1 alanine racemase -
MWM14_RS17800 (PthBH41_34680) 3534869..3535882 - 1014 WP_035502536.1 outer membrane lipoprotein carrier protein LolA -
MWM14_RS17805 (PthBH41_34690) 3535964..3536326 - 363 WP_003253427.1 holo-ACP synthase -
MWM14_RS17810 (PthBH41_34700) 3536389..3537003 + 615 WP_013401779.1 rhomboid family intramembrane serine protease -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(4-111)

Antitoxin


No domain identified.



Sequences


Toxin        


Download         Length: 117 a.a.        Molecular weight: 12992.00 Da        Isoelectric Point: 4.8781

>T40463 WP_003253417.1 NZ_AP025621:c3533124-3532774 [Parageobacillus thermoglucosidasius]
MIVKRGDVYFADLSPVVGSEQGGVRPVLVIQNDIGNRFSPTVIVAAITAQIQKAKLPTHVEIDAKRYGFERDSVILLEQI
RTIDKQRLTDKITHLDDEMMDKVDEALQISLGLIDF

Download         Length: 351 bp

>T40463 NZ_AP025621:c3533124-3532774 [Parageobacillus thermoglucosidasius]
TTGATTGTTAAGCGTGGCGACGTTTATTTTGCGGACCTTTCCCCGGTAGTTGGCTCGGAACAAGGAGGCGTTCGTCCGGT
ATTAGTCATTCAAAATGACATTGGAAATCGGTTTAGTCCGACGGTGATTGTGGCGGCGATAACAGCGCAAATCCAAAAAG
CAAAGCTGCCGACACATGTTGAAATTGACGCGAAGCGTTACGGGTTTGAGCGGGATTCTGTTATTCTGCTAGAGCAAATT
CGGACGATTGATAAGCAGCGGCTGACAGACAAAATTACTCACTTGGACGATGAAATGATGGATAAGGTGGATGAAGCGCT
GCAAATTAGTTTAGGACTCATAGATTTTTAG

Antitoxin


Download         Length: 94 a.a.        Molecular weight: 10631.16 Da        Isoelectric Point: 7.0142

>AT40463 WP_003253419.1 NZ_AP025621:c3533410-3533129 [Parageobacillus thermoglucosidasius]
VSESSATTEIVVRLPQALVTELDVLVKQENGNRNDLIYQATKMYIRERKKRQIREAMRRGYMEMAKINLSIASEAFLAEY
EADHTVERLVSGG

Download         Length: 282 bp

>AT40463 NZ_AP025621:c3533410-3533129 [Parageobacillus thermoglucosidasius]
GTGTCGGAATCTAGCGCAACAACGGAAATCGTCGTTCGTTTACCTCAAGCACTAGTAACGGAATTGGATGTGCTTGTTAA
ACAAGAGAACGGCAACCGTAATGATCTCATTTATCAAGCAACTAAAATGTACATTCGCGAGCGAAAAAAACGGCAAATCC
GCGAGGCGATGAGACGCGGTTATATGGAAATGGCGAAAATCAATTTATCCATTGCTTCAGAGGCGTTTCTTGCAGAATAT
GAAGCCGACCACACCGTTGAGCGTTTAGTTAGCGGGGGGTAA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB A0A7U9ERQ4


Antitoxin

Source ID Structure
AlphaFold DB A0A178U3Z0

References