Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/PRK09907-MazE
Location 360820..361514 Replicon chromosome
Accession NZ_AP025621
Organism Parageobacillus thermoglucosidasius strain BH4-1

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag MWM14_RS01840 Protein ID WP_035501708.1
Coordinates 361128..361514 (+) Length 129 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID -
Locus tag MWM14_RS01835 Protein ID WP_035501704.1
Coordinates 360820..361128 (+) Length 103 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MWM14_RS01800 356064..356366 - 303 WP_003247860.1 ATP-binding protein -
MWM14_RS01805 356408..356513 - 106 Protein_318 helix-turn-helix domain-containing protein -
MWM14_RS01810 (PthBH41_03190) 356723..357013 - 291 Protein_319 AAA family ATPase -
MWM14_RS01815 (PthBH41_03200) 357148..358653 + 1506 WP_003247862.1 IS21 family transposase -
MWM14_RS01820 (PthBH41_03210) 358654..359376 + 723 WP_003247864.1 IS21-like element helper ATPase IstB -
MWM14_RS01825 359422..359577 - 156 WP_255210113.1 hypothetical protein -
MWM14_RS01830 (PthBH41_03220) 359711..360181 - 471 WP_003247869.1 transposase family protein -
MWM14_RS01835 (PthBH41_03230) 360820..361128 + 309 WP_035501704.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
MWM14_RS01840 (PthBH41_03240) 361128..361514 + 387 WP_035501708.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
MWM14_RS01845 (PthBH41_03250) 361706..362596 + 891 WP_244410878.1 transposase -
MWM14_RS01850 (PthBH41_03260) 363058..364323 - 1266 WP_003247880.1 glycosyltransferase family 39 protein -
MWM14_RS01855 (PthBH41_03270) 364340..364708 - 369 WP_035501712.1 EamA family transporter -
MWM14_RS01860 (PthBH41_03280) 364695..365063 - 369 WP_035501714.1 DUF2304 domain-containing protein -
MWM14_RS01865 (PthBH41_03290) 365082..365765 - 684 WP_003247882.1 glycosyltransferase family 2 protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 344873..361514 16641


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(5-119)

Antitoxin

Antitoxin PemI-like

(23-100)


Sequences

Toxin        


Download         Length: 129 a.a.        Molecular weight: 14327.35 Da        Isoelectric Point: 4.6207

>T40462 WP_035501708.1 NZ_AP025621:361128-361514 [Parageobacillus thermoglucosidasius]
MPADVPERGDFVVLNFNPQAGYEQAGRRNAIVLSPKEFNQATGFIAVCPITNQKKGYPFEVDLPKEGISPDGDGYPITGV
VLTDRIKSLDWKARNLKILKKYNPEDAQIEEIDKIIDECLAKIETYLT

Download         Length: 387 bp

>T40462 NZ_AP025621:361128-361514 [Parageobacillus thermoglucosidasius]
ATGCCAGCAGACGTACCAGAGAGAGGCGATTTCGTTGTTTTAAACTTCAATCCACAAGCTGGTTATGAGCAGGCTGGGAG
AAGGAATGCTATTGTTTTATCGCCTAAAGAATTCAATCAAGCAACAGGATTTATAGCTGTTTGTCCGATTACCAATCAAA
AGAAGGGTTATCCCTTCGAAGTGGATTTGCCAAAAGAAGGAATATCCCCTGATGGCGATGGCTATCCAATAACAGGGGTA
GTTTTAACTGATCGAATTAAATCATTGGATTGGAAAGCTCGTAATCTAAAAATTTTAAAGAAGTATAATCCAGAAGATGC
ACAAATTGAAGAAATAGATAAAATCATTGATGAATGCCTAGCGAAAATAGAAACATATCTGACTTGA

Antitoxin


Download         Length: 103 a.a.        Molecular weight: 11626.33 Da        Isoelectric Point: 7.2033

>AT40462 WP_035501704.1 NZ_AP025621:360820-361128 [Parageobacillus thermoglucosidasius]
MYSKEHLENKINQSKGADYMSTVIVQKWGNSLGIRIPKDAADKIGIKQGSEMELNVIGNEGIITLKPKRTRKKYTLEELI
SQITPENRHEEIDFGIEGRELI

Download         Length: 309 bp

>AT40462 NZ_AP025621:360820-361128 [Parageobacillus thermoglucosidasius]
ATGTATTCAAAAGAACATTTAGAAAACAAGATAAACCAGAGTAAAGGGGCTGACTACATGTCTACAGTTATTGTTCAAAA
ATGGGGAAACAGTTTGGGCATTCGTATCCCAAAAGATGCTGCTGATAAAATAGGGATTAAACAAGGTTCCGAAATGGAAT
TAAACGTGATTGGAAATGAAGGTATCATCACATTAAAGCCAAAAAGAACACGGAAGAAATACACACTGGAAGAACTAATA
TCACAGATTACACCTGAAAATCGACACGAGGAAATTGATTTCGGGATAGAAGGGCGTGAATTGATTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References