Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/PRK09907-MazE
Location 360820..361514 Replicon chromosome
Accession NZ_AP025621
Organism Parageobacillus thermoglucosidasius strain BH4-1

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag MWM14_RS01840 Protein ID WP_035501708.1
Coordinates 361128..361514 (+) Length 129 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID -
Locus tag MWM14_RS01835 Protein ID WP_035501704.1
Coordinates 360820..361128 (+) Length 103 a.a.

Genomic Context

MWM14_RS01815MWM14_RS01820MWM14_RS01835MWM14_RS01840MWM14_RS01845MWM14_RS01800MWM14_RS01805MWM14_RS01810MWM14_RS01825MWM14_RS01830MWM14_RS01850MWM14_RS01855MWM14_RS01860MWM14_RS01865
Location: 357148..358653 (1506 bp)
Type: Others
Protein ID: WP_003247862.1
Location: 358654..359376 (723 bp)
Type: Others
Protein ID: WP_003247864.1
Location: 360820..361128 (309 bp)
Type: Antitoxin
Protein ID: WP_035501704.1
Location: 361128..361514 (387 bp)
Type: Toxin
Protein ID: WP_035501708.1
Location: 361706..362596 (891 bp)
Type: Others
Protein ID: WP_244410878.1
Location: 356064..356366 (303 bp)
Type: Others
Protein ID: WP_003247860.1
Location: 356408..356513 (106 bp)
Type: Others
Protein ID: Protein_318
Location: 356723..357013 (291 bp)
Type: Others
Protein ID: Protein_319
Location: 359422..359577 (156 bp)
Type: Others
Protein ID: WP_255210113.1
Location: 359711..360181 (471 bp)
Type: Others
Protein ID: WP_003247869.1
Location: 363058..364323 (1266 bp)
Type: Others
Protein ID: WP_003247880.1
Location: 364340..364708 (369 bp)
Type: Others
Protein ID: WP_035501712.1
Location: 364695..365063 (369 bp)
Type: Others
Protein ID: WP_035501714.1
Location: 365082..365765 (684 bp)
Type: Others
Protein ID: WP_003247882.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
MWM14_RS01800356064..356366-303WP_003247860.1ATP-binding protein-
MWM14_RS01805356408..356513-106Protein_318helix-turn-helix domain-containing protein-
MWM14_RS01810 (PthBH41_03190)356723..357013-291Protein_319AAA family ATPase-
MWM14_RS01815 (PthBH41_03200)357148..358653+1506WP_003247862.1IS21 family transposase-
MWM14_RS01820 (PthBH41_03210)358654..359376+723WP_003247864.1IS21-like element helper ATPase IstB-
MWM14_RS01825359422..359577-156WP_255210113.1hypothetical protein-
MWM14_RS01830 (PthBH41_03220)359711..360181-471WP_003247869.1transposase family protein-
MWM14_RS01835 (PthBH41_03230)360820..361128+309WP_035501704.1AbrB/MazE/SpoVT family DNA-binding domain-containing proteinAntitoxin
MWM14_RS01840 (PthBH41_03240)361128..361514+387WP_035501708.1type II toxin-antitoxin system PemK/MazF family toxinToxin
MWM14_RS01845 (PthBH41_03250)361706..362596+891WP_244410878.1transposase-
MWM14_RS01850 (PthBH41_03260)363058..364323-1266WP_003247880.1glycosyltransferase family 39 protein-
MWM14_RS01855 (PthBH41_03270)364340..364708-369WP_035501712.1EamA family transporter-
MWM14_RS01860 (PthBH41_03280)364695..365063-369WP_035501714.1DUF2304 domain-containing protein-
MWM14_RS01865 (PthBH41_03290)365082..365765-684WP_003247882.1glycosyltransferase family 2 protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideGenomic island--344873..36151416641


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(5-119)

Antitoxin

Antitoxin PemI-like

(23-100)


Sequences

Toxin        


Download         Length: 129 a.a.        Molecular weight: 14327.35 Da        Isoelectric Point: 4.6207

>T40462 WP_035501708.1 NZ_AP025621:361128-361514 [Parageobacillus thermoglucosidasius]
MPADVPERGDFVVLNFNPQAGYEQAGRRNAIVLSPKEFNQATGFIAVCPITNQKKGYPFEVDLPKEGISPDGDGYPITGV
VLTDRIKSLDWKARNLKILKKYNPEDAQIEEIDKIIDECLAKIETYLT

Download         Length: 387 bp

>T40462 NZ_AP025621:361128-361514 [Parageobacillus thermoglucosidasius]
ATGCCAGCAGACGTACCAGAGAGAGGCGATTTCGTTGTTTTAAACTTCAATCCACAAGCTGGTTATGAGCAGGCTGGGAG
AAGGAATGCTATTGTTTTATCGCCTAAAGAATTCAATCAAGCAACAGGATTTATAGCTGTTTGTCCGATTACCAATCAAA
AGAAGGGTTATCCCTTCGAAGTGGATTTGCCAAAAGAAGGAATATCCCCTGATGGCGATGGCTATCCAATAACAGGGGTA
GTTTTAACTGATCGAATTAAATCATTGGATTGGAAAGCTCGTAATCTAAAAATTTTAAAGAAGTATAATCCAGAAGATGC
ACAAATTGAAGAAATAGATAAAATCATTGATGAATGCCTAGCGAAAATAGAAACATATCTGACTTGA

Antitoxin


Download         Length: 103 a.a.        Molecular weight: 11626.33 Da        Isoelectric Point: 7.2033

>AT40462 WP_035501704.1 NZ_AP025621:360820-361128 [Parageobacillus thermoglucosidasius]
MYSKEHLENKINQSKGADYMSTVIVQKWGNSLGIRIPKDAADKIGIKQGSEMELNVIGNEGIITLKPKRTRKKYTLEELI
SQITPENRHEEIDFGIEGRELI

Download         Length: 309 bp

>AT40462 NZ_AP025621:360820-361128 [Parageobacillus thermoglucosidasius]
ATGTATTCAAAAGAACATTTAGAAAACAAGATAAACCAGAGTAAAGGGGCTGACTACATGTCTACAGTTATTGTTCAAAA
ATGGGGAAACAGTTTGGGCATTCGTATCCCAAAAGATGCTGCTGATAAAATAGGGATTAAACAAGGTTCCGAAATGGAAT
TAAACGTGATTGGAAATGAAGGTATCATCACATTAAAGCCAAAAAGAACACGGAAGAAATACACACTGGAAGAACTAATA
TCACAGATTACACCTGAAAATCGACACGAGGAAATTGATTTCGGGATAGAAGGGCGTGAATTGATTTAA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
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Antitoxin

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Source
ID
Structure
No matching records found

References