Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pmenTA/darT(toxin)
Location 1700749..1702505 Replicon chromosome
Accession NZ_AP025613
Organism Thermus thermophilus strain SNM6-6

Toxin (Protein)


Gene name pmenT Uniprot ID -
Locus tag SNM_RS09270 Protein ID WP_126187536.1
Coordinates 1700749..1701366 (+) Length 206 a.a.

Antitoxin (Protein)


Gene name pmenA Uniprot ID -
Locus tag SNM_RS09275 Protein ID WP_126201461.1
Coordinates 1701432..1702505 (+) Length 358 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SNM_RS09235 (TthSNM66_18110) 1695960..1696253 - 294 WP_244346590.1 hypothetical protein -
SNM_RS09240 (TthSNM66_18120) 1696246..1696635 - 390 WP_244346591.1 hypothetical protein -
SNM_RS09245 (TthSNM66_18130) 1696662..1697471 - 810 WP_244346592.1 hypothetical protein -
SNM_RS09250 (TthSNM66_18140) 1697472..1698530 - 1059 WP_244346593.1 baseplate J/gp47 family protein -
SNM_RS09255 (TthSNM66_18150) 1698527..1699138 - 612 WP_126204661.1 hypothetical protein -
SNM_RS09260 (TthSNM66_18160) 1699142..1700407 - 1266 WP_244346594.1 hypothetical protein -
SNM_RS09265 (TthSNM66_18170) 1700434..1700628 - 195 WP_244346595.1 PAAR domain-containing protein -
SNM_RS09270 (TthSNM66_18180) 1700749..1701366 + 618 WP_126187536.1 DUF4433 domain-containing protein Toxin
SNM_RS09275 (TthSNM66_18190) 1701432..1702505 + 1074 WP_126201461.1 macro domain-containing protein Antitoxin
SNM_RS09280 (TthSNM66_18200) 1702603..1703604 - 1002 WP_244346596.1 phage baseplate assembly protein V -
SNM_RS09285 (TthSNM66_18210) 1703613..1705064 - 1452 WP_244346597.1 hypothetical protein -
SNM_RS09290 (TthSNM66_18220) 1705085..1705645 + 561 WP_126201511.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

ssDNA thymidine ADP-ribosyltransferase, DarT

(12-205)

Antitoxin

Macro domain

(18-130)


Sequences

Toxin        


Download         Length: 206 a.a.        Molecular weight: 23837.28 Da        Isoelectric Point: 9.6021

>T40456 WP_126187536.1 NZ_AP025613:1700749-1701366 [Thermus thermophilus]
MAPPYPYPTLIYHITHIKNLASILETGGLLPLNRSPRHQSIAYEHIRERRGQTRVPLKPGGTLNDYVPFYFCPRSPMLYA
VHTGSTDYWGGQTPILHLVSSVQAVHAKGLDFVFTDQHAVLLHARFFNNPQDLSKLDWGAIQASFWSQVKAQKQAEFLVY
DFFPWDLVQEIGVIDDKIAQEVRQILQRFPNRRHPPVRVRRDWYY

Download         Length: 618 bp

>T40456 NZ_AP025613:1700749-1701366 [Thermus thermophilus]
ATGGCGCCACCTTATCCCTATCCCACGCTCATCTACCACATCACCCACATAAAAAACCTTGCAAGCATCCTGGAAACCGG
AGGACTCCTGCCCCTCAATCGGTCCCCCCGCCACCAAAGCATCGCCTATGAGCACATTCGGGAGCGCCGAGGCCAGACCC
GCGTTCCCTTGAAGCCCGGAGGGACGTTAAACGACTACGTTCCCTTTTACTTCTGCCCCCGCTCCCCCATGCTGTACGCC
GTTCATACGGGTTCTACCGACTACTGGGGAGGGCAAACACCCATCTTGCACCTGGTCTCCTCGGTACAAGCGGTTCACGC
TAAGGGACTAGACTTTGTGTTCACCGACCAGCACGCCGTTTTGCTCCATGCCCGGTTCTTCAACAACCCCCAGGACCTCA
GCAAGCTGGACTGGGGAGCCATCCAGGCTTCGTTTTGGAGCCAGGTGAAGGCGCAAAAACAAGCGGAGTTCCTGGTTTAT
GATTTCTTTCCTTGGGACTTAGTTCAGGAAATCGGGGTTATAGACGATAAGATAGCCCAAGAGGTGCGGCAAATCCTCCA
GAGGTTCCCCAACCGGCGCCACCCTCCAGTGCGAGTCCGTCGGGACTGGTATTATTAA

Antitoxin


Download         Length: 358 a.a.        Molecular weight: 40483.56 Da        Isoelectric Point: 8.9839

>AT40456 WP_126201461.1 NZ_AP025613:1701432-1702505 [Thermus thermophilus]
MLRFVQGDLLQAPVEALVNTVNTVGVMGKGVALRFKRAFPENYKAYVQACQRGEVQIGRIFVHDRGVLARPRYILNFPTK
KHWRYPSRMEYVEEGLKDLVRVIRELGIRSLALPPLGAGNGGLPWPEVRQRIQDALKPLEDVEILVYEPQNAELPPIAPL
PTKPRLTKARAALLKLFGLYGAWEDIGRLEAQKLAYFLQEAGLDLRLNFTRNTYGPYAEPLNHVLARLEGHYIQGYGDRN
TPSHMRLREGALKEAVAFLADHPDADEAASRAATWVEGFEDSYGLELLATVHWAVRREGARTWDDLRKVLQAWGPRKAKI
PQRDLEVALYYLLQRGALQPEEWSDRVVLPEDAPQLA

Download         Length: 1074 bp

>AT40456 NZ_AP025613:1701432-1702505 [Thermus thermophilus]
ATGCTCCGCTTCGTGCAAGGCGACCTCCTTCAGGCCCCGGTAGAGGCCCTGGTAAACACGGTGAACACCGTGGGGGTCAT
GGGCAAAGGGGTGGCCTTGCGGTTCAAGCGGGCCTTCCCCGAAAACTACAAGGCCTACGTTCAGGCCTGCCAACGGGGCG
AAGTGCAGATTGGACGTATCTTCGTCCACGACCGGGGAGTCCTGGCCCGCCCCCGCTACATCCTCAACTTCCCCACCAAA
AAGCACTGGCGCTACCCCTCGAGGATGGAATACGTGGAGGAGGGGCTCAAGGACCTGGTTCGGGTCATCCGCGAGCTTGG
AATACGCTCCCTGGCCCTCCCCCCCCTGGGTGCGGGCAACGGCGGCCTGCCCTGGCCCGAGGTGCGCCAACGCATCCAGG
ATGCCCTAAAACCCTTGGAAGACGTGGAAATCTTGGTCTACGAACCCCAGAACGCCGAGCTTCCCCCCATTGCCCCCTTG
CCTACCAAACCCCGCCTTACCAAGGCCCGTGCGGCCCTCCTCAAGCTTTTCGGCCTCTACGGGGCTTGGGAGGACATCGG
GCGCCTCGAGGCGCAAAAGTTGGCCTACTTCCTTCAGGAGGCAGGCCTGGACCTGAGGCTGAACTTCACCCGCAACACCT
ATGGCCCTTACGCCGAGCCCCTGAATCACGTGCTAGCCCGCCTCGAGGGCCACTACATCCAAGGCTACGGTGACCGGAAC
ACTCCCTCCCACATGCGCCTCCGGGAAGGCGCCCTCAAGGAGGCGGTAGCCTTCCTGGCCGACCACCCCGATGCGGACGA
GGCCGCAAGCCGGGCCGCAACCTGGGTGGAGGGGTTCGAGGATTCCTATGGTCTCGAGCTTCTGGCCACCGTGCACTGGG
CCGTGCGCCGGGAAGGAGCCAGGACCTGGGATGACCTTCGGAAAGTTTTGCAGGCCTGGGGGCCCCGCAAGGCCAAAATC
CCACAAAGGGACCTGGAGGTGGCCCTTTACTACCTGCTTCAACGGGGGGCCCTCCAGCCTGAGGAGTGGTCCGACCGGGT
TGTGCTGCCCGAAGACGCTCCCCAACTTGCCTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References