Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC(toxin)
Location 1464909..1465561 Replicon chromosome
Accession NZ_AP025613
Organism Thermus thermophilus strain SNM6-6

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag SNM_RS07955 Protein ID WP_244346476.1
Coordinates 1465169..1465561 (+) Length 131 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag SNM_RS07950 Protein ID WP_244346474.1
Coordinates 1464909..1465169 (+) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SNM_RS07935 (TthSNM66_15510) 1461203..1462585 + 1383 WP_244346469.1 FAD-linked oxidase C-terminal domain-containing protein -
SNM_RS07940 (TthSNM66_15520) 1462572..1463615 + 1044 WP_244346470.1 FAD-binding protein -
SNM_RS07945 (TthSNM66_15530) 1463620..1464876 + 1257 WP_244346472.1 glycolate oxidase subunit GlcF -
SNM_RS07950 (TthSNM66_15540) 1464909..1465169 + 261 WP_244346474.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
SNM_RS07955 (TthSNM66_15550) 1465169..1465561 + 393 WP_244346476.1 type II toxin-antitoxin system VapC family toxin Toxin
SNM_RS07960 (TthSNM66_15560) 1465546..1466766 + 1221 WP_244346478.1 glycerate kinase -
SNM_RS07965 (TthSNM66_15570) 1466771..1467088 + 318 WP_014509970.1 nucleotidyltransferase domain-containing protein -
SNM_RS07970 (TthSNM66_15580) 1467078..1467476 + 399 WP_165738949.1 HEPN domain-containing protein -
SNM_RS07975 (TthSNM66_15590) 1467469..1468566 + 1098 WP_244346481.1 radical SAM family heme chaperone HemW -
SNM_RS07980 (TthSNM66_15600) 1468569..1468958 - 390 WP_011227977.1 NADH-quinone oxidoreductase subunit 15 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(1-124)

Antitoxin

Antitoxin VapB-like

(1-85)


Sequences

Toxin        


Download         Length: 131 a.a.        Molecular weight: 14696.93 Da        Isoelectric Point: 6.8732

>T40455 WP_244346476.1 NZ_AP025613:1465169-1465561 [Thermus thermophilus]
MVLDTSALLAMLFREEGYEELLEQLRRTRPHKVAAPTLAEAGIVLGARLGFERVHLLFVLLTELQAEIVPFTERHAREAI
SAYRRYGRGKHPAGLNFGDCLSYALARVEGEPLLYKGQDFDRTDLAWKPS

Download         Length: 393 bp

>T40455 NZ_AP025613:1465169-1465561 [Thermus thermophilus]
ATGGTGCTGGACACCTCCGCCCTCCTGGCCATGCTCTTTCGGGAAGAGGGGTACGAGGAGCTTTTGGAGCAACTCCGGCG
CACCCGCCCCCACAAGGTGGCCGCGCCCACCCTGGCCGAAGCGGGGATCGTCCTGGGCGCCCGGCTGGGCTTTGAGCGGG
TGCATCTTCTCTTTGTACTCCTAACCGAGCTCCAGGCCGAGATCGTGCCCTTCACCGAAAGGCATGCCCGGGAGGCCATC
TCCGCTTACCGGCGCTACGGGCGGGGCAAGCACCCCGCCGGGCTCAACTTTGGGGACTGCCTGAGCTACGCCCTGGCCCG
GGTGGAGGGGGAACCCCTCCTCTACAAGGGCCAGGACTTTGACCGGACGGACCTGGCGTGGAAGCCCTCCTGA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 10074.55 Da        Isoelectric Point: 5.0285

>AT40455 WP_244346474.1 NZ_AP025613:1464909-1465169 [Thermus thermophilus]
MALTIRNKEVERLAEEVARLAGETKTEAVRKALEMRLRELQRKRSFDRVIRFLEEEVWPQIPPELLGKGISKEEEEETLG
YGKEGY

Download         Length: 261 bp

>AT40455 NZ_AP025613:1464909-1465169 [Thermus thermophilus]
ATGGCCCTCACCATCCGCAACAAGGAGGTGGAGCGCCTGGCCGAGGAGGTGGCCCGCCTCGCCGGAGAAACCAAGACGGA
GGCCGTAAGGAAGGCCCTGGAGATGCGCCTTAGGGAACTCCAGAGGAAGCGGAGCTTTGACCGGGTGATCCGCTTCCTGG
AAGAGGAAGTCTGGCCCCAGATCCCGCCGGAGCTTTTGGGGAAGGGGATCTCCAAGGAAGAGGAGGAAGAGACCCTGGGG
TACGGCAAGGAGGGGTACTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References