40450

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pmenTA/darT(toxin)
Location 276979..278699 Replicon chromosome
Accession NZ_AP025603
Organism Thermus thermophilus strain SNM1-7

Toxin (Protein)


Gene name pmenT Uniprot ID -
Locus tag MWM12_RS01550 Protein ID WP_244341259.1
Coordinates 276979..277608 (+) Length 210 a.a.

Antitoxin (Protein)


Gene name pmenA Uniprot ID -
Locus tag MWM12_RS01555 Protein ID WP_244341261.1
Coordinates 277617..278699 (+) Length 361 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MWM12_RS01530 (TthSNM17_02950) 272132..274609 + 2478 WP_244341252.1 DUF3987 domain-containing protein -
MWM12_RS01535 (TthSNM17_02960) 274596..275165 + 570 WP_071677565.1 DUF4411 family protein -
MWM12_RS01540 (TthSNM17_02970) 275135..275356 - 222 WP_244341255.1 hypothetical protein -
MWM12_RS01545 (TthSNM17_02980) 275353..276945 - 1593 WP_244341257.1 site-specific DNA-methyltransferase -
MWM12_RS01550 (TthSNM17_02990) 276979..277608 + 630 WP_244341259.1 DUF4433 domain-containing protein Toxin
MWM12_RS01555 (TthSNM17_03000) 277617..278699 + 1083 WP_244341261.1 macro domain-containing protein Antitoxin
MWM12_RS01560 (TthSNM17_03010) 278760..279122 - 363 WP_008631029.1 hypothetical protein -
MWM12_RS01565 (TthSNM17_03020) 279657..279914 + 258 WP_060384760.1 helix-turn-helix transcriptional regulator -
MWM12_RS01570 (TthSNM17_03030) 279895..281028 + 1134 WP_038034998.1 site-specific integrase -
MWM12_RS01580 (TthSNM17_03040) 281304..283259 + 1956 WP_011227715.1 transketolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 268475..281028 12553


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

ssDNA thymidine ADP-ribosyltransferase, DarT

(15-209)

Antitoxin

Macro domain

(18-130)


Sequences

Toxin        


Download         Length: 210 a.a.        Molecular weight: 24433.21 Da        Isoelectric Point: 10.1712

>T40450 WP_244341259.1 NZ_AP025603:276979-277608 [Thermus thermophilus]
MPQQSPVYPVPTRIYHITHLENLEGILQKGGLLPQSQRPPTRQNVAYGHIQARRAEVVVPVGPRGKLHDYVPFYFCPRSP
MLYAIHTGWTEYQGGQRPILHLVSTAQRVAEERLPFVFTDRHAAVRYVRFFHKLEHLKALDWEAIHSFDWRNTRERKQAE
FLVKGLFPWRLIEEIGVIDEGIKAKVESVLARFPGLPHPPVQVRRSWYY

Download         Length: 630 bp

>T40450 NZ_AP025603:276979-277608 [Thermus thermophilus]
ATGCCACAGCAAAGCCCGGTCTATCCGGTGCCCACGCGCATCTACCACATCACCCACCTGGAAAACCTCGAGGGCATCCT
CCAGAAGGGGGGCCTCCTCCCCCAATCCCAAAGGCCCCCTACGCGGCAGAATGTGGCCTACGGGCACATCCAGGCCCGCC
GGGCGGAAGTCGTGGTGCCCGTGGGCCCGAGGGGCAAGCTCCACGATTACGTGCCGTTTTACTTCTGCCCCCGTTCCCCT
ATGCTCTACGCCATCCACACCGGATGGACCGAATACCAAGGGGGCCAGCGCCCCATCCTGCACCTGGTCTCCACCGCCCA
AAGGGTGGCGGAAGAGCGTCTGCCCTTCGTGTTCACCGACCGCCACGCGGCCGTTCGGTACGTTCGCTTCTTCCACAAGT
TGGAGCACCTGAAGGCCTTGGACTGGGAGGCAATCCATTCTTTTGACTGGCGCAATACCCGCGAGAGAAAACAGGCCGAG
TTCCTGGTCAAGGGCCTCTTCCCCTGGAGGTTGATTGAGGAGATCGGCGTCATAGACGAGGGCATAAAGGCTAAGGTGGA
GTCCGTCCTTGCCCGGTTCCCCGGGCTACCCCATCCCCCGGTGCAGGTGCGCCGGAGTTGGTACTATTAG

Antitoxin


Download         Length: 361 a.a.        Molecular weight: 40647.05 Da        Isoelectric Point: 10.2233

>AT40450 WP_244341261.1 NZ_AP025603:277617-278699 [Thermus thermophilus]
MLRFVRGDLLKAPVEALVNTVNTVGVMGKGVALQFKRAFPDNYQAYVQACKRGEVQIGRIFVHDRGPLAQPRYIFNFPTK
KHWRHPARMEYVEEGLKDLVRQIRELRVRSIALPPLGAGNGKLPWPEVKRRIQEALAPLEDVEVLVYEPPGEPQTHLIAP
QGTKPRLTPARAALLKLFGLYGALGEPLGRLEAQKLAYFLQEAGLDLRLAFVRQRFGPYAEPLNHVLVRLEGHYIRGFGD
RAGASQIRLEPQALNEAILYLADHPEADEAATRAAEWVKGFETPYGLELLATVHWAVRHEGARDWATLQKVLRTWSPRKA
TFPRTHIQVALDALLKRGALRPEEWRDRLPKPPANVAQEA

Download         Length: 1083 bp

>AT40450 NZ_AP025603:277617-278699 [Thermus thermophilus]
ATGCTCCGCTTCGTGCGAGGCGACCTCCTCAAAGCCCCGGTGGAGGCCCTGGTCAACACGGTGAACACCGTGGGGGTCAT
GGGCAAGGGGGTGGCCTTGCAGTTCAAGCGGGCTTTCCCGGACAACTACCAGGCCTACGTGCAGGCCTGTAAGCGGGGCG
AGGTCCAGATTGGCCGCATCTTCGTCCACGACCGAGGGCCCCTGGCCCAGCCCCGCTACATCTTCAACTTCCCCACCAAG
AAGCACTGGCGCCACCCCGCCCGCATGGAGTACGTGGAGGAGGGGCTAAAGGACCTGGTGCGCCAAATCCGGGAGCTTCG
GGTCCGCTCCATCGCCTTGCCCCCCTTGGGGGCCGGGAACGGGAAGCTTCCCTGGCCCGAGGTCAAGCGGCGCATCCAGG
AGGCCCTGGCGCCCCTCGAGGACGTGGAGGTCTTGGTCTACGAACCTCCGGGGGAACCCCAGACCCACCTCATCGCCCCC
CAAGGGACCAAGCCCCGCCTCACCCCTGCCCGGGCCGCCCTGCTCAAGCTCTTCGGCCTTTATGGGGCGCTTGGGGAACC
CTTGGGCCGCCTCGAGGCCCAAAAGCTGGCCTACTTCCTTCAGGAAGCGGGTTTGGATCTTAGGCTTGCCTTTGTCCGTC
AGCGGTTTGGCCCCTACGCCGAGCCCTTGAACCACGTGCTGGTCCGCCTCGAGGGCCACTACATCCGGGGCTTCGGAGAC
CGCGCGGGGGCTTCCCAGATACGCCTCGAGCCTCAGGCTCTGAACGAGGCCATCCTCTACTTGGCCGACCACCCTGAGGC
CGACGAGGCCGCCACCCGGGCGGCGGAATGGGTCAAGGGGTTTGAGACCCCTTATGGCCTAGAGCTTCTGGCCACGGTCC
ACTGGGCCGTGCGCCACGAGGGGGCCCGGGACTGGGCTACCCTGCAAAAGGTGCTCCGAACCTGGAGCCCCCGCAAGGCC
ACTTTTCCCCGGACCCACATTCAGGTAGCCCTGGACGCCCTCTTGAAGCGGGGGGCCCTCCGCCCCGAGGAGTGGCGGGA
CCGGCTTCCTAAACCGCCCGCCAACGTGGCCCAGGAAGCTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References