Detailed information of TA system TA040439

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/YafQ-DinJ
• Location: 1893737..1894271
• Replicon: chromosome
• Accession: NZ_AP025585
• Organism: Pyramidobacter piscolens strain CE91-St28

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: MWL86_RS09125
• Protein ID: WP_154529436.1
• Coordinates: 1893996..1894271 (+)
• Length: 92 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: MWL86_RS09120
• Protein ID: WP_154527881.1
• Coordinates: 1893737..1894003 (+)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MWL86_RS09080 (CE91St28_17850)	1889137..1889853	-	717	WP_244388471.1	B3/4 domain-containing protein	-
MWL86_RS09085 (CE91St28_17860)	1889951..1890361	-	411	WP_154527876.1	methylmalonyl-CoA epimerase	-
MWL86_RS09090 (CE91St28_17870)	1890495..1891154	-	660	WP_009166126.1	A24 family peptidase	-
MWL86_RS09095 (CE91St28_17880)	1891160..1891711	-	552	WP_009166125.1	isochorismatase family protein	-
MWL86_RS09100 (CE91St28_17890)	1891848..1892438	+	591	WP_244388472.1	hypothetical protein	-
MWL86_RS09110 (CE91St28_17900)	1892683..1893159	+	477	WP_244388473.1	SsrA-binding protein SmpB	-
MWL86_RS09120 (CE91St28_17910)	1893737..1894003	+	267	WP_154527881.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
MWL86_RS09125 (CE91St28_17920)	1893996..1894271	+	276	WP_154529436.1	type II toxin-antitoxin system YafQ family toxin	Toxin
MWL86_RS09130 (CE91St28_17930)	1894405..1895142	-	738	WP_244388474.1	IclR family transcriptional regulator	-
MWL86_RS09135 (CE91St28_17940)	1895407..1896426	+	1020	WP_154527884.1	tryptophan--tRNA ligase	-
MWL86_RS09140 (CE91St28_17950)	1896505..1897089	-	585	WP_244388475.1	isoprenylcysteine carboxylmethyltransferase family protein	-
MWL86_RS09145 (CE91St28_17960)	1897079..1898146	-	1068	WP_244388476.1	lysylphosphatidylglycerol synthase transmembrane domain-containing protein	-
MWL86_RS09150 (CE91St28_17970)	1898143..1898751	-	609	WP_244388477.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-90)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (5-77)

Sequences

Toxin

Protein

• Length: 92 a.a.
• Molecular weight: 10717.20 Da
• Isoelectric Point: 6.8609

>T40439 WP_154529436.1 NZ_AP025585:1893996-1894271 [Pyramidobacter piscolens]
MLNLRYQSAFKSDYKRIRKRGYDIRRLEDVIETLAKELPLPKECRDHDLGGNWSGFRECHIEPDWLLVYAIDHNDLVLIL
SRTGSHSDLFG

Nucleotide

• Length: 276 bp

>T40439 NZ_AP025585:1893996-1894271 [Pyramidobacter piscolens]
ATGCTTAACCTCAGATATCAGTCGGCCTTCAAGAGCGACTACAAGCGTATCCGCAAGCGTGGGTACGATATTCGGCGGCT
GGAAGACGTCATCGAAACGCTCGCAAAAGAGCTGCCTCTCCCCAAAGAGTGCCGCGACCACGATTTGGGCGGCAATTGGT
CAGGGTTTCGCGAGTGCCATATCGAGCCGGACTGGTTGCTCGTCTACGCTATTGACCATAACGATTTGGTCTTGATCCTC
AGCCGTACCGGTTCGCACAGCGATCTGTTCGGATAA

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 9870.25 Da
• Isoelectric Point: 6.3196

>AT40439 WP_154527881.1 NZ_AP025585:1893737-1894003 [Pyramidobacter piscolens]
MATTNVTVRMDENLKADFEEMLADFGLNTSVAINIFARQVVYERRIPFAIARDRPNAATRAAMEDTRARRGLSKTFSSVK
DLMADLDA

Nucleotide

• Length: 267 bp

>AT40439 NZ_AP025585:1893737-1894003 [Pyramidobacter piscolens]
ATGGCGACAACCAACGTCACCGTAAGAATGGACGAAAACCTGAAAGCCGATTTCGAAGAAATGCTCGCCGACTTCGGGCT
GAATACGTCGGTGGCCATTAACATCTTTGCGCGCCAGGTCGTGTACGAGCGGCGGATCCCGTTCGCCATCGCGCGCGACC
GCCCCAACGCTGCGACGCGCGCAGCCATGGAAGACACCCGCGCGCGCCGCGGCCTGAGCAAGACTTTCTCGTCCGTAAAA
GACTTGATGGCCGATCTCGATGCTTAA