Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/PRK09907-MazE
Location 977246..977808 Replicon chromosome
Accession NZ_AP025585
Organism Pyramidobacter piscolens strain CE91-St28

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag MWL86_RS04520 Protein ID WP_244389340.1
Coordinates 977479..977808 (+) Length 110 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID -
Locus tag MWL86_RS04515 Protein ID WP_244389339.1
Coordinates 977246..977485 (+) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MWL86_RS04480 (CE91St28_08960) 972877..973404 + 528 WP_009164468.1 NUDIX hydrolase -
MWL86_RS04485 (CE91St28_08970) 973479..974372 + 894 WP_009164467.1 tyrosine-type recombinase/integrase -
MWL86_RS04490 (CE91St28_08980) 974411..975244 + 834 WP_040550479.1 purine-nucleoside phosphorylase -
MWL86_RS04495 (CE91St28_08990) 975259..975645 + 387 WP_009164465.1 J domain-containing protein -
MWL86_RS04505 976212..976373 + 162 WP_244389515.1 type II toxin-antitoxin system RelE/ParE family toxin -
MWL86_RS04510 (CE91St28_09000) 976360..976644 + 285 WP_040550454.1 helix-turn-helix transcriptional regulator -
MWL86_RS04515 (CE91St28_09010) 977246..977485 + 240 WP_244389339.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
MWL86_RS04520 (CE91St28_09020) 977479..977808 + 330 WP_244389340.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
MWL86_RS04525 (CE91St28_09030) 978073..978957 - 885 WP_244389341.1 LysR family transcriptional regulator -
MWL86_RS04530 (CE91St28_09040) 979103..980896 + 1794 WP_244389342.1 indolepyruvate ferredoxin oxidoreductase subunit alpha -
MWL86_RS04535 (CE91St28_09050) 980893..981486 + 594 WP_244389343.1 indolepyruvate oxidoreductase subunit beta -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(1-98)

Antitoxin

SpoVT-AbrB domain

(7-48)


Sequences

Toxin        


Download         Length: 110 a.a.        Molecular weight: 11991.93 Da        Isoelectric Point: 6.7095

>T40436 WP_244389340.1 NZ_AP025585:977479-977808 [Pyramidobacter piscolens]
MVRQGDIVLVNFTPQSGHEQAGKRPAVVVSNDVFNEKTSMTIVCPVTNADNKFPLHVPLDGRTRTTGVILCEHVKALDIE
ARGYKVVERVPSDILARVVQLVGMEIEIL

Download         Length: 330 bp

>T40436 NZ_AP025585:977479-977808 [Pyramidobacter piscolens]
ATGGTAAGGCAAGGCGACATCGTTCTTGTCAACTTCACGCCGCAGTCGGGGCACGAACAGGCGGGCAAACGTCCGGCCGT
GGTGGTCAGCAACGACGTGTTCAACGAGAAAACATCAATGACGATTGTCTGTCCCGTGACCAACGCCGACAACAAATTCC
CGCTGCACGTGCCGCTCGACGGGCGGACGCGCACGACGGGCGTTATCCTCTGCGAGCACGTGAAAGCCCTCGACATCGAG
GCGCGGGGATATAAAGTCGTCGAGCGCGTGCCGTCCGACATTCTGGCGCGGGTCGTGCAGCTGGTCGGCATGGAGATTGA
AATACTGTAA

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 8945.15 Da        Isoelectric Point: 7.9780

>AT40436 WP_244389339.1 NZ_AP025585:977246-977485 [Pyramidobacter piscolens]
MPVTISRWGNSRGVRIPKAVLERLNWTDSELVEITAENDSIIIRRARPRQTIADLFAGYGGAYRCEAVDWGKPEGKEAW

Download         Length: 240 bp

>AT40436 NZ_AP025585:977246-977485 [Pyramidobacter piscolens]
ATGCCTGTGACCATCAGCCGGTGGGGAAACAGCCGCGGCGTCAGGATTCCCAAAGCCGTTCTTGAACGCCTGAACTGGAC
GGACAGCGAGCTTGTCGAAATCACGGCCGAAAACGACAGCATCATCATCCGCCGCGCCCGGCCGCGGCAGACCATTGCCG
ATTTGTTCGCCGGTTACGGCGGCGCGTACCGCTGCGAGGCCGTGGATTGGGGAAAGCCCGAAGGAAAAGAAGCATGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References