Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) higB-toxA/Tad-couple_hipB
Location 976212..976644 Replicon chromosome
Accession NZ_AP025585
Organism Pyramidobacter piscolens strain CE91-St28

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag MWL86_RS04505 Protein ID WP_244389515.1
Coordinates 976212..976373 (+) Length 54 a.a.

Antitoxin (Protein)


Gene name toxA Uniprot ID -
Locus tag MWL86_RS04510 Protein ID WP_040550454.1
Coordinates 976360..976644 (+) Length 95 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MWL86_RS04470 (CE91St28_08940) 971433..971912 + 480 WP_009164470.1 peptide deformylase -
MWL86_RS04475 (CE91St28_08950) 971909..972841 + 933 WP_244389338.1 methionyl-tRNA formyltransferase -
MWL86_RS04480 (CE91St28_08960) 972877..973404 + 528 WP_009164468.1 NUDIX hydrolase -
MWL86_RS04485 (CE91St28_08970) 973479..974372 + 894 WP_009164467.1 tyrosine-type recombinase/integrase -
MWL86_RS04490 (CE91St28_08980) 974411..975244 + 834 WP_040550479.1 purine-nucleoside phosphorylase -
MWL86_RS04495 (CE91St28_08990) 975259..975645 + 387 WP_009164465.1 J domain-containing protein -
MWL86_RS04505 976212..976373 + 162 WP_244389515.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
MWL86_RS04510 (CE91St28_09000) 976360..976644 + 285 WP_040550454.1 helix-turn-helix transcriptional regulator Antitoxin
MWL86_RS04515 (CE91St28_09010) 977246..977485 + 240 WP_244389339.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein -
MWL86_RS04520 (CE91St28_09020) 977479..977808 + 330 WP_244389340.1 type II toxin-antitoxin system PemK/MazF family toxin -
MWL86_RS04525 (CE91St28_09030) 978073..978957 - 885 WP_244389341.1 LysR family transcriptional regulator -
MWL86_RS04530 (CE91St28_09040) 979103..980896 + 1794 WP_244389342.1 indolepyruvate ferredoxin oxidoreductase subunit alpha -
MWL86_RS04535 (CE91St28_09050) 980893..981486 + 594 WP_244389343.1 indolepyruvate oxidoreductase subunit beta -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(3-40)

Antitoxin

(37-89)


Sequences


Toxin        


Download         Length: 54 a.a.        Molecular weight: 6320.25 Da        Isoelectric Point: 8.8959

>T40435 WP_244389515.1 NZ_AP025585:976212-976373 [Pyramidobacter piscolens]
MRDRILFAAWVDGGFVLLHAFVKKTQKTPRREIEQAKRELADFVERSVHHEQE

Download         Length: 162 bp

>T40435 NZ_AP025585:976212-976373 [Pyramidobacter piscolens]
CTGCGCGACCGAATTCTTTTTGCCGCGTGGGTTGACGGCGGTTTTGTGCTGCTTCATGCTTTCGTGAAGAAGACCCAGAA
GACGCCGCGTCGCGAAATCGAGCAGGCTAAAAGGGAACTGGCGGACTTCGTCGAAAGGAGCGTTCACCATGAACAGGAAT
AG

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 10332.11 Da        Isoelectric Point: 8.7131

>AT40435 WP_040550454.1 NZ_AP025585:976360-976644 [Pyramidobacter piscolens]
MNRNSAVGMSLEELERELLTPEEIAESNVRVAIIGELIKARQARGLTQRKLEELSGVKQPVIARMEKGTTNPQLDTVIKL
LAPLGKTLAVVDLK

Download         Length: 285 bp

>AT40435 NZ_AP025585:976360-976644 [Pyramidobacter piscolens]
ATGAACAGGAATAGCGCTGTGGGCATGAGCCTTGAAGAACTGGAACGGGAACTGCTGACGCCGGAAGAGATTGCCGAAAG
CAACGTCCGCGTGGCCATTATCGGCGAACTCATCAAGGCCCGTCAGGCGCGCGGCCTCACGCAAAGGAAGCTTGAAGAGC
TGTCCGGCGTGAAGCAGCCCGTCATTGCCAGAATGGAAAAGGGTACGACCAATCCCCAGCTGGACACGGTGATAAAACTG
CTGGCCCCCTTGGGGAAGACCTTGGCCGTCGTAGACCTGAAATGA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure


Antitoxin

Source ID Structure

References