Detailed information of TA system TA040434

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/YafQ-DinJ
• Location: 920209..920743
• Replicon: chromosome
• Accession: NZ_AP025585
• Organism: Pyramidobacter piscolens strain CE91-St28

Toxin (Protein)

• Gene name: relE
• Uniprot ID: D1Y3V1
• Locus tag: MWL86_RS04235
• Protein ID: WP_009164532.1
• Coordinates: 920468..920743 (+)
• Length: 92 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: MWL86_RS04230
• Protein ID: WP_040550473.1
• Coordinates: 920209..920475 (+)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MWL86_RS04220 (CE91St28_08450)	917684..917911	+	228	WP_156797436.1	hypothetical protein	-
MWL86_RS04225 (CE91St28_08460)	917978..919618	-	1641	WP_244389310.1	IS1634 family transposase	-
MWL86_RS04230 (CE91St28_08470)	920209..920475	+	267	WP_040550473.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
MWL86_RS04235 (CE91St28_08480)	920468..920743	+	276	WP_009164532.1	type II toxin-antitoxin system YafQ family toxin	Toxin
MWL86_RS12865 (CE91St28_08490)	921142..921345	-	204	WP_279612192.1	GDP-mannose 4,6-dehydratase	-
MWL86_RS04245 (CE91St28_08500)	921768..923018	+	1251	WP_244389311.1	nucleotide sugar dehydrogenase	-
MWL86_RS04250 (CE91St28_08510)	923046..924887	+	1842	WP_244389312.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, YafQ-like toxin (4-91)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (1-86)

Sequences

Toxin

Protein

• Length: 92 a.a.
• Molecular weight: 10781.26 Da
• Isoelectric Point: 6.4762

>T40434 WP_009164532.1 NZ_AP025585:920468-920743 [Pyramidobacter piscolens]
MLNLRYQSAFKRDYKRIRKRGYDVQRLESIIEMLAKEQVLPEECRDHDLGGTWSGFRECHIEPDWLLVYTIDHNDLVLVL
SRTGSHSDLFG

Nucleotide

• Length: 276 bp

>T40434 NZ_AP025585:920468-920743 [Pyramidobacter piscolens]
ATGCTTAACCTCAGATATCAGTCGGCCTTCAAGCGCGACTACAAGCGTATCCGCAAACGGGGGTACGATGTTCAGCGGCT
GGAAAGCATCATCGAGATGCTCGCCAAAGAGCAGGTGCTCCCCGAGGAGTGCCGCGACCACGATTTGGGCGGCACTTGGT
CGGGGTTCCGCGAGTGCCATATCGAGCCGGACTGGCTGCTCGTCTACACCATCGACCATAACGATTTGGTCTTGGTCCTC
AGCCGTACCGGTTCGCACAGCGATCTGTTCGGATAA

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 9868.28 Da
• Isoelectric Point: 6.3196

>AT40434 WP_040550473.1 NZ_AP025585:920209-920475 [Pyramidobacter piscolens]
MATTNVTVRMDENLKADFEEMLADFGLNTSVAINIFARQVVYERRIPFVIARDRPNAATRAAMEDARARRGLSKTFSSVK
DLMADLDA

Nucleotide

• Length: 267 bp

>AT40434 NZ_AP025585:920209-920475 [Pyramidobacter piscolens]
ATGGCGACAACCAACGTCACCGTAAGGATGGACGAAAATCTGAAAGCCGATTTCGAAGAAATGCTCGCCGACTTCGGGCT
GAATACGTCGGTGGCCATTAACATCTTCGCGCGCCAAGTCGTGTACGAGCGGCGGATCCCGTTCGTGATTGCGCGCGACC
GCCCCAACGCCGCGACGCGTGCGGCCATGGAAGACGCCCGCGCGCGCCGCGGCCTGAGCAAGACCTTCTCGTCCGTGAAA
GACCTGATGGCCGATCTCGATGCTTAA

Structures

Toxin

• AlphaFold DB: D1Y3V1